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Preparation of a cranio-maxillofacial bone repairing and fixing device

A fixation device, bone repair technology, applied in the direction of fixator, internal bone synthesis, coating, etc., can solve problems such as affecting the use of materials

Inactive Publication Date: 2016-10-26
TIANJIN SANNIE BIOENG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through years of clinical use, it has been found that in addition to the above-mentioned advantages, this type of polymer also has some biocompatibility problems described above, thus affecting the use of this material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Use magnesium-zinc-calcium alloy to produce plates with length, width, and height of 40mm, 6mm, and 1mm by machining, and have holes with a diameter of 2mm, and then use magnesium-zinc-calcium alloy to make screws with a length of 4mm and a diameter of 2mm. The manufactured boards and screws are cleaned and then dried for use. Take 5g of L-polylactic acid with a molecular weight of 12KDa and dissolve it in 100ml of dichloromethane. After stirring evenly, slowly dissolve 0.5g of magnesium oxide in the solution, and ultrasonically distribute the magnesium oxide in the solution evenly. After weighing the finished plate and screw made of magnesium-zinc-calcium alloy, soak in the polylactic acid solution mixed with magnesium oxide for 5 to 10 minutes, then lift and air-dry, and then soak in the solution again after drying until the final weight is 5% of the weight ends soaking, and finally washes with ethanol for 3 times, and drys and packs and irradiates and sterilizes to c...

Embodiment 2

[0017] Use pure magnesium to produce plates with a length, width, and height of 80mm, 80mm, and 1mm, and holes with a diameter of 2mm, and then use pure magnesium to make screws with a length of 4mm and a diameter of 2mm. The manufactured boards and screws are cleaned and then dried for use. Take 5g of L-polylactic acid with a molecular weight of 22KDa and dissolve it in 100ml of chloroform. After stirring evenly, slowly dissolve 0.25g of magnesium carbonate in the solution, and ultrasonically distribute the magnesium carbonate in the solution evenly. After weighing the boards and screws that have been processed with pure magnesium, soak them in the polylactic acid solution mixed with magnesium carbonate for 20-30 minutes, then pull and air-dry them, and soak them in the solution again after drying until the final weight is equal to that of the original boards or screws. After the weight is 10%, the immersion is finished, and finally, the ethanol is used to wash 3 times, and t...

Embodiment 3

[0019] Two gaskets with a diameter of 15 mm and a thickness of 1 mm, and one round rod with a diameter of 2 mm and a length of 60 mm were produced by machining magnesium-zinc-zirconium alloy. The made pads and round rods are polished and cleaned and then dried for use. Take 3g of L-polylactic acid with a molecular weight of 50KDa and dissolve it in 100ml of tetrahydrofuran, stir well, then slowly dissolve 0.3g of magnesium phosphate into the solution, and ultrasonically distribute the magnesium carbonate in the solution evenly. After weighing the processed plates and screws, soak them in the polylactic acid solution mixed with magnesium carbonate for 30-40 minutes, then pull and air-dry them, and soak them in the solution again after drying until the final weight is the weight of the original gasket or round rod After 20% of the immersion, the immersion is finished, and finally cleaned 3 times with ethanol, dried and packaged, and irradiated to complete the sterilization.

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Abstract

The invention discloses a device formed by coating components made of a degradable magnesium-based metal with a compound polymer material and used for of cranio-maxillofacial bone repairing and fixing, and belongs to the field of biodegradable materials. The device mainly overcomes defects that a second operation is required to take out cranio-maxillofacial bone repairing and fixing materials in clinic due to poor biocompatibility and no degradability of the materials. A manner of solution pulling wind-drying manner is adopted to cover the magnesium-based metal components with the compound polymer material so as to prepare the device good in biocompatibility and adjustable in degradation time.

Description

technical field [0001] The invention relates to a device for repairing and fixing craniomaxillofacial bone composed of parts made of degradable magnesium-based metals coated with composite polymer materials. It belongs to the field of biodegradable materials. Background technique [0002] At present, craniomaxillofacial repair fixation devices used in clinical practice are basically composed of metal materials or polymer materials. The metal materials used are all non-degradable materials, most of which are made of titanium-based metals. Craniomaxillofacial fixation devices made of polymer materials are generally made of polyetheretherketone or polylactic acid, where polyetheretherketone is non-degradable and polylactic acid can be degraded. Judging from the current clinical use of products made of these two materials, they can basically meet the clinical requirements, but there are also some limitations and potential problems. For example, for craniofacial repair in chil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/10A61L31/14A61B17/80A61B17/86
CPCA61B17/80A61B17/86A61L31/028A61L31/10A61L31/148A61L2420/04C08L67/04
Inventor 毕宏伟
Owner TIANJIN SANNIE BIOENG TECH