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Degradable medical magnesium-based biological material applied to cranio-maxillofacial bone

A technology for maxillofacial bone and magnesium-based metals, which is applied in the field of degradable medical magnesium-based biomaterials, and can solve problems affecting treatment effects, bone development in children, and inflammatory reactions.

Inactive Publication Date: 2019-05-24
南杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, for the repair of the lower craniomaxillofacial area in children, because the bones of children are not yet fully mature, if non-degradable materials are used as repair and fixation materials, it will affect the bone development of children, form developmental obstacles, and cause long-term problems
In addition, the products made of degradable polylactic acid materials currently used clinically, because polylactic acid will release lactic acid monomers in the human body during the degradation process, resulting in an acidic environment in the body tissues, resulting in tissue accumulation and inflammatory reactions, affecting Therapeutic effect, even need to remove the implant in severe cases
From the above simple analysis, it can be seen that in the field of mandibular and maxillofacial bone repair, there is not yet a mandibular and maxillofacial bone repair and fixation that has good biocompatibility, degradability, and controllable degradation time to meet the requirements. clinical needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The magnesium-zinc-calcium alloy is used for machining to produce plates with length, width, and height of 40mm, 6mm, 1mm, and a hole with a diameter of 2mm, and then a magnesium-zinc-calcium alloy is used to make screws with a length of 4mm and a diameter of 2mm. The plates and screws made are dried after finishing cleaning. Take 5g of L-polylactic acid with a molecular weight of 12KDa and dissolve it in 100ml of dichloromethane. After stirring, 0.5g of magnesium oxide is slowly dissolved in the solution, and the magnesium oxide is uniformly distributed in the solution by ultrasound. After weighing the plates and screws that have been processed with magnesium-zinc-calcium alloy, they are soaked in a polylactic acid solution mixed with magnesium oxide for 5-10 minutes and then pulled to air dry. After drying, they are soaked in the solution again until the final weight is the plate The 5% of the weight is finished soaking, and then washed with ethanol 3 times, dried and ...

Embodiment 2

[0015] Use pure magnesium to produce a plate with a length, width, and height of 80mm, 80mm, 1mm and a hole with a diameter of 2mm, and then use pure magnesium to make a screw with a length of 4mm and a diameter of 2mm. The plates and screws made are dried after finishing cleaning. Take 5g of L-polylactic acid with a molecular weight of 22KDa and dissolve it in 100ml of chloroform. After stirring, 0.25g of magnesium carbonate is slowly dissolved in the solution, and the magnesium carbonate is uniformly distributed in the solution by ultrasound. After weighing the plates and screws that have been processed with pure magnesium, they are soaked in a polylactic acid solution mixed with magnesium carbonate for 20-30 minutes and then pulled to air dry. After drying, they are soaked in the solution again until the final weight is the original plate or screw. After the weight is 10%, the soaking is finished, and then washed with ethanol 3 times, dried, packaged, and sterilized by irrad...

Embodiment 3

[0017] Two gaskets with a diameter of 15mm and a thickness of 1mm, and one round bar with a diameter of 2mm and a length of 60mm were fabricated by machining from a magnesium-zinc-zirconium alloy. The made gaskets and round rods are cleaned by light decoration and dried for later use. Take 3g of L-polylactic acid with a molecular weight of 50KDa and dissolve it in 100ml of tetrahydrofuran, stir evenly and then slowly dissolve 0.3g of magnesium phosphate in the solution, and make the magnesium carbonate uniformly distributed in the solution by ultrasound. Weigh the finished plates and screws, soak them in a polylactic acid solution mixed with magnesium carbonate for 30-40 minutes, then pull them to air dry, and then soak them in the solution again after drying until the final weight is the weight of the original gasket or round bar End the soaking after 20% of the content, and then rinse with ethanol 3 times, dry the package and irradiate the sterilization to complete.

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PUM

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Abstract

The invention discloses a degradable medical magnesium-based biological material applied to cranio-maxillofacial bone and belongs to the technical field of biodegradable materials. The degradable medical magnesium-based biological material applied to cranio-maxillofacial bone mainly solves the shortcomings that cranio-maxillofacial bone repair and fixation materials for clinical use are poor in compatibility and nondegradable and need to be drawn out through secondary surgery. Through a solution coating and air-drying method, compound high-polymer materials are wrapped outside the surface of amagnesium-based metal part to prepare a cranio-maxillofacial bone repair and fixation device good in biocompatibility and controllable in degradation time.

Description

Technical field [0001] The invention relates to a degradable medical magnesium-based biological material applied to cranio-maxillofacial bones. It belongs to the field of biodegradable materials. Background technique [0002] At present, the mandibular and maxillofacial repair and fixation devices used in clinical practice are basically composed of metal materials or polymer materials. The metal materials used are all non-degradable materials, most of which are made of magnesium-based metals. Mandibular and maxillofacial repair and fixation devices made of polymeric polymer materials are generally made of polyether ether ketone or polylactic acid, among which polyether ether ketone is not degradable, and polylactic acid can be degraded. Judging from the current clinical use of products made of these two materials, it can basically meet clinical requirements, but there are also some limitations and potential problems. For example, for pediatric mandibular and maxillofacial repa...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/04A61L27/16A61L27/18
Inventor 南杰
Owner 南杰