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Sulfated gellan gum, anti-collapsing calcium sulfate hemihydrate bone cement with anti-inflammatory and osteogenesis-promoting effects, preparation methods of sulfated gellan gum and anti-collapsing calcium sulfate hemihydrate bone cement, and application of anti-collapsing calcium sulfate hemihydrate bone cement

A technology of calcium sulfate hemihydrate and gellan gum, which is used in pharmaceutical formulations, medical science, prostheses, etc., can solve the problems affecting the application range of α-CSH, the easy collapse of calcium sulfate hemihydrate bone cement, and the poor repair effect of bone defects. problems, to achieve good biocompatibility and biological activity, promote rapid repair, easy to operate

Pending Publication Date: 2021-10-22
广州睿康医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the deficiencies in the prior art, one of the objectives of the present invention is to provide a sulfated gellan gum, which can regulate the phenotypic polarization of macrophages, thereby changing the inflammatory microenvironment of the defect site In order to promote the bone microenvironment and solve the problem of aseptic inflammation during the use of artificial bone materials
Moreover, α-CSH bone cement is easy to collapse and disintegrate during the application process, resulting in poor repair effect of bone defects, which seriously affects the application range of α-CSH
Sulfated gellan gum can be combined with calcium sulfate hemihydrate bone cement formed by α-calcium sulfate hemihydrate, strontium carbonate and gluconolactone, and the Sr released slowly after sulfated gellan gum reacts with strontium carbonate and gluconolactone 2+ Cross-linking forms a gel network, thereby solving the problem of easy collapse of calcium sulfate hemihydrate bone cement, and promoting the rapid repair of bone defects

Method used

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  • Sulfated gellan gum, anti-collapsing calcium sulfate hemihydrate bone cement with anti-inflammatory and osteogenesis-promoting effects, preparation methods of sulfated gellan gum and anti-collapsing calcium sulfate hemihydrate bone cement, and application of anti-collapsing calcium sulfate hemihydrate bone cement
  • Sulfated gellan gum, anti-collapsing calcium sulfate hemihydrate bone cement with anti-inflammatory and osteogenesis-promoting effects, preparation methods of sulfated gellan gum and anti-collapsing calcium sulfate hemihydrate bone cement, and application of anti-collapsing calcium sulfate hemihydrate bone cement
  • Sulfated gellan gum, anti-collapsing calcium sulfate hemihydrate bone cement with anti-inflammatory and osteogenesis-promoting effects, preparation methods of sulfated gellan gum and anti-collapsing calcium sulfate hemihydrate bone cement, and application of anti-collapsing calcium sulfate hemihydrate bone cement

Examples

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Embodiment 1

[0067] The present embodiment carries out the preparation of anti-collapse calcium sulfate hemihydrate bone cement with anti-inflammatory and bone-promoting effects, comprising the following steps:

[0068] 1) With 142g sodium sulfate and 110.9g calcium chloride as raw materials, α-calcium sulfate hemihydrate was prepared by hydrothermal salt solution method at 120°C; then 145.15g α-calcium sulfate hemihydrate, 1.4763g strontium carbonate, 0.8907g The gluconolactone powder was mixed, and ball milled for 1 hour with a ball mill to make it evenly mixed to obtain calcium sulfate hemihydrate bone cement powder.

[0069] 2) 1g of gellan gum is mixed with an organic acid solution formed by 50mL of DMF and 1mL of dichloroacetic acid, then heated and stirred at 90°C until the gellan gum dissolves to form a uniform solution, namely the gellan gum solution; 5mL of chlorosulfonic acid ( HClSO 3 ) was added dropwise to 50mL of cold DMF solution at 0°C, and stirred evenly to form DMF-HClS...

Embodiment 2

[0072] The present embodiment carries out the preparation of anti-collapse calcium sulfate hemihydrate bone cement with anti-inflammatory and bone-promoting effects, comprising the following steps:

[0073] 1) With 142g sodium sulfate and 110.9g calcium chloride as raw materials, α-calcium sulfate hemihydrate was prepared by hydrothermal salt solution method at 130°C; then 145.15g α-calcium sulfate hemihydrate, 14.763g strontium carbonate, 8.907g The gluconolactone powder was mixed, and ball milled for 3 hours with a ball mill to make it evenly mixed to obtain calcium sulfate hemihydrate bone cement powder.

[0074] 2) Mix 1 g of gellan gum with an organic acid solution formed by 50 mL of DMF and 3 mL of citric acid, then heat and stir at 90° C. until the gellan gum dissolves to form a uniform solution that is gellan gum solution; 15 mL of chlorosulfonic acid (HClSO 3 ) was added dropwise to 50mL of cold DMF solution at 4°C, and stirred evenly to form DMF-HClSO 3 mixed soluti...

Embodiment 3

[0078] The present embodiment carries out the preparation of anti-collapse calcium sulfate hemihydrate bone cement with anti-inflammatory and bone-promoting effects, comprising the following steps:

[0079] 1) With 142g sodium sulfate and 110.9g calcium chloride as raw materials, α-calcium sulfate hemihydrate was prepared by hydrothermal salt solution method at 140°C; then 145.15g α-calcium sulfate hemihydrate, 7.3815g strontium carbonate, 4.4535g The gluconolactone powder was mixed, and ball milled for 2 hours with a ball mill to make it evenly mixed to obtain calcium sulfate hemihydrate bone cement powder.

[0080] 2) Mix 1g of gellan gum with an organic acid solution formed by 50mL of DMF and 5ml of acetic acid, then heat and stir at 90°C until the gellan gum dissolves to form a uniform solution, namely the gellan gum solution; mix 10mL of chlorosulfonic acid (HClSO 3 ) was added dropwise to 50mL of cold DMF solution at 10°C, and stirred evenly to form DMF-HClSO 3 mixed so...

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Abstract

The invention relates to the technical field of bone defect repair, in particular to sulfated gellan gum, anti-collapsing calcium sulfate hemihydrate bone cement with anti-inflammatory and osteogenesis-promoting effects, preparation methods of the sulfated gellan gum and the anti-collapsing calcium sulfate hemihydrate bone cement, and application of the anti-collapsing calcium sulfate hemihydrate bone cement. According to the sulfated gellan gum provided by the invention, phenotypic polarization of macrophages can be regulated and controlled, an inflammation microenvironment of a defect part is converted into an osteogenesis promoting microenvironment, and the problem of sterile inflammation generated in the use process of an artificial bone material is solved. Moreover, the sulfated gellan gum can be combined with calcium sulfate hemihydrate bone cement formed by alpha-calcium sulfate hemihydrate, strontium carbonate and glucolactone, and Sr < 2 + > slowly released after the sulfated gellan gum reacts with strontium carbonate and glucolactone is crosslinked to form a gel network, so that the problem that the calcium sulfate hemihydrate bone cement is easy to collapse is solved; and rapid repair of bone defects is promoted. The invention provides the anti-collapsing calcium sulfate hemihydrate bone cement. The anti-collapsing calcium sulfate hemihydrate bone cement has excellent anti-inflammatory, osteogenesis-promoting, anti-collapsing and injectable properties.

Description

technical field [0001] The invention relates to the technical field of bone defect repair, in particular to sulfated gellan gum, an anti-collapse calcium sulfate hemihydrate bone cement with anti-inflammatory and osteogenic effects, and a preparation method and application thereof. Background technique [0002] At present, the more commonly used method for treating bone defects is mainly surgery, that is, using bone substitutes to fill the defect and eliminate dead space, so as to restore the morphology, mechanical strength and anatomical function of the lesion, including: natural bone (autologous bone, allograft) transplantation and artificial bone repair. Autologous bone is the gold standard for the treatment of normal bone defects. Since it comes from the patient itself, it is non-immunogenic and does not need to worry about rejection, and the treatment effect is better. However, due to the low strength and density of the patient's own bone, the autogenous bone will caus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61L27/02A61L27/20A61L27/50A61L27/52A61L27/54
CPCC08B37/006A61L27/20A61L27/025A61L27/50A61L27/52A61L27/54A61L2300/41A61L2300/412A61L2430/02A61L2400/06A61L2430/12C08L5/00
Inventor 屠美杨慎宇黄伊平陈晓明陈淑萍陈俊宇
Owner 广州睿康医疗科技有限公司