Preparation method of [3-(dimethylamino)propyl]triphenylphosphonium bromide hydrobromide

A technology of dimethylamino and hydrobromide is applied in the field of preparation of [3-propyl]triphenylphosphonium bromide hydrobromide, which can solve the problem of reducing raw material cost, high reaction efficiency, reducing energy consumption, etc. To achieve the effect of reducing raw material cost, high reaction efficiency and reducing energy consumption
CN106046053AInactive Publication Date: 2016-10-26HUZHOU HENGYUAN BIOCHEM TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HUZHOU HENGYUAN BIOCHEM TECH
Publication Date
2016-10-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of [3-(dimethylamino)propyl]triphenylphosphonium bromide hydrobromide. The preparation method is characterized by comprising the following steps: (1) 180-220 kg of toluene is pumped into a reaction kettle, 80-100 kg of triphenyl phosphine is added manually, 50-70 kg of 1,3-dibromopropane is added dropwise at a relatively high speed to an elevated tank, flux is performed for 5-6 h at normal pressure and at the temperature of 80 DEG C, and P-I is obtained through cooling, filtering and drying; (2) 350-420 kg of methanol is pumped into the reaction kettle, 150 kg of P-I is added to methanol manually, 80-120 kg of a dimethylamine aqueous solution is added dropwise to the elevated tank, and a reaction is performed for 10-14 h at normal pressure and at the temperature of 50 DEG C after addition; (3) methanol is evaporated to dryness after the reaction, 360-450 kg of ethanol is pumped in, cooling, filtering and drying are performed after heating for dissolution, and [3-(dimethylamino)propyl]triphenylphosphonium bromide hydrobromide is obtained.
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Description

technical field

[0001] The invention relates to the field of chemical industry, in particular to an improved preparation method of [3-(dimethylamino)propyl]triphenylphosphine bromide hydrobromide. Background technique

[0002] Histamine is an active substance that exists in the body itself. It mainly forms complexes with polysaccharide sulfate, heparin or chondroitin sulfate and acidic proteins and exists in the granules of mast cells and basophils, especially in the lungs. , skin mucous membrane, bronchial mucous membrane, gastric mucosa and gastric parietal cells. When the tissue is stimulated by immune response or physical or chemical, it can cause mast cells to degranulate and release histamine, and the released histamine binds to histamine receptors, resulting in a pathophysiological response. Olopatadine hydrochloride is a safe and effective new type of histamine H1 receptor antagonist, which can highly selectively block the combination of histamine and H1 receptor, w...

Claims

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