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Real-time controllable micro-liquid-drop transportation method based on C-shaped cut lithium niobate chip

A technology for cutting lithium niobate and microdroplets, which is applied in the direction of analyzing materials and instruments, can solve the problems of low reliability, complex chip structure, poor regulation of transport action, etc., and achieves high chip reliability, simple chip structure, The effect of flexible control

Inactive Publication Date: 2016-11-09
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The micro-droplet transportation methods reported so far have defects such as complex chip structure, low reliability, high requirements on the physical properties of the droplets to be transported, and poor controllability of transport operations.

Method used

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  • Real-time controllable micro-liquid-drop transportation method based on C-shaped cut lithium niobate chip
  • Real-time controllable micro-liquid-drop transportation method based on C-shaped cut lithium niobate chip
  • Real-time controllable micro-liquid-drop transportation method based on C-shaped cut lithium niobate chip

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0029]A laser with a wavelength of 488nm was used, a halogen lamp was selected as the background light source, the magnification of the focusing objective lens was 25 times, and the volume of the micro-droplet (deionized water) to be transported was 0.2 μL. Turn on the laser, adjust the spatial position of the micro-droplet so that the focused spot is located at its edge, and adjust the focused laser power to 15 mW. The movement of the C-cut lithium niobate chip is controlled by the computer, so that the laser spot scans along a certain path on its surface, and the micro-droplets will move together with the laser spot to realize the transport of the micro-droplets, and the transport speed is 133μm / s .

example 2

[0031] A laser with a wavelength of 532nm was used, a halogen lamp was selected as the background light source, the magnification of the focusing objective lens was 25 times, and the volume of the micro-droplet (saline) to be transported was 0.3 μL. Turn on the laser, adjust the spatial position of the micro-droplet so that the focus spot is located at its edge, and adjust the focus laser power to 16mW. The movement of the C-cut lithium niobate chip is controlled by the computer, so that the laser spot scans along a certain path on the surface, and the micro-droplets will move together with the laser spot to realize the transport of the micro-droplets. The transport speed is 33μm / s .

example 3

[0033] A laser with a wavelength of 405nm was used, a white LED light was used as the background light source, the magnification of the focusing objective lens was 25 times, and the volume of the micro-droplet (deionized water) to be transported was 0.1 μL. Turn on the laser, adjust the spatial position of the micro-droplet so that the focus spot is located at its edge, and adjust the focus laser power to 16mW. The movement of the C-cut lithium niobate chip is controlled by the computer, so that the laser spot scans along a certain path on the surface, and the micro-droplets will move together with the laser spot to realize the transport of the micro-droplets, and the transport speed is 153μm / s .

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Abstract

The invention discloses a micro-liquid-drop transportation method, the method takes a C-shaped cut lithium niobate substrate and a polytetrafluoroethylene hydrophobic membrane as a core, uses a photoelectric wetting effect for driving micro liquid drops, and the micro liquid drops are driven by the scanning motion of the laser focusing light spots on the C-shaped cut lithium niobate chip for transport according to any two-dimensional path. The chip required by the method has a simple and reliable structure, flexible regulation and control can be carried out on the transport motion of the micro liquid drops by controlling the light spot scanning path and the laser power, can be used for polar liquid, and has no special requirements on physical property of the micro liquid drops to be transported. The method can be used for transporting the microscale chemical reagents and the fluid samples during a biological, chemical and medical analysis process, and has very important meaning for the development of fields such as bio-medical treatment, medical diagnosis, environment monitoring and molecular biology.

Description

technical field [0001] The invention relates to a micro-droplet control technology, in particular to a micro-droplet transportation method with simple and reliable chip structure, wide range of liquids to be applied, and flexible control of transport action. Background technique [0002] With the rapid development of microfluidic chips, more and more attention has been paid to the control technology of micro-droplets. Micro-droplet control technology is generally used in the analysis process of micro-sample in the fields of biology, chemistry, and pharmacy, and it mainly involves the transportation and mixing of micro-quantity reagents. It is of great significance to the development of fields such as biomedicine, drug diagnosis, food hygiene, environmental monitoring and molecular biology. [0003] Literature (William H.Grover, Alison M.Skelley, Chung N, Liu, Eric T.Lagally, Richard A.Matthies, Monolithic membrane valves and diaphragm pumps for practical large-scale integra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/00
CPCG01N35/00
Inventor 樊博麟阎文博陈立品陈洪建王旭亮李少北李菲菲张羽晴
Owner HEBEI UNIV OF TECH
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