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Dimercaprol medicine composition and application of dimercaprol medicine composition to biological medicines

A technology of dimercaptopropanol and composition, applied in pharmaceutical composition and its application field in biomedicine, can solve the problems such as no reports on the correlation of dimercaptopropanol with migraine, and achieve the effect of improving therapeutic effect

Inactive Publication Date: 2016-11-16
陈露
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between dimercaprol and its pharmaceutical composition and migraine

Method used

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  • Dimercaprol medicine composition and application of dimercaprol medicine composition to biological medicines
  • Dimercaprol medicine composition and application of dimercaprol medicine composition to biological medicines
  • Dimercaprol medicine composition and application of dimercaprol medicine composition to biological medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0019] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0020] Separation method: (a) Grind Houttuynia cordata (2kg), extract with 65% ethanol under heat reflux (20L×3 times), combine the extracts, concentrate until no alcohol smell (4L), and then use petroleum ether (4L×3 times), ethyl acetate (4L × 3 times) and water-saturated n-butanol (4L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step ( a) The n-butanol extract is removed with AB-8 macroporous resin, first eluted with 10% ethanol for 12 column volumes, then with 70% ethanol for 15 column volumes, collected 70% eluate, and reduced Concentra...

Embodiment 2

[0024] Embodiment 2: pharmacological action

[0025] In this example, nitroglycerin was used to prepare a rat model of migraine, and the anti-migraine effect of the drug on increasing 5-hydroxytryptamine (5-HT) and decreasing calcitonin gene-related peptide (CGRP) was observed.

[0026] 1. Materials and methods

[0027] 1.1 Animals

[0028] SD rats, half male and half female, 180-220 g, clean grade, were purchased from the Institute of Experimental Animals, Sichuan Academy of Medical Sciences.

[0029] 1.2 Reagents and samples

[0030] Dimercaprol was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Sumatriptan succinate tablets (Tianjin Huajin Pharmaceutical Factory). Nitroglycerin injection (Zhengzhou Lingrui Pharmaceutical Co., Ltd.). Rat calcitonin gene-related peptide (CGRP) kit (Beimian Dongya Biotechnology Research Institute); rat 5-hydroxytryptamine...

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Abstract

The invention discloses a pharmaceutical composition of dimercaprol and its application in biomedicine. The pharmaceutical composition of dimercaprol provided by the invention contains dimercaprol and a natural product compound (I) with a novel structure , when dimercaprol and compound (I) act alone, they have a therapeutic effect on migraine; The medicine has outstanding substantive features and significant progress compared with the prior art.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of dimercaprol, in particular to a pharmaceutical composition of dimercaprol and its application in biomedicine. Background technique [0002] Dimercaprol is a competitive antidote, which is often used clinically for heavy metal poisoning, and forms complexes with heavy metals, thereby eliminating heavy metals from the body. [0003] So far, there has been no report on the correlation between dimercaprol and its pharmaceutical composition and migraine. Contents of the invention [0004] The object of the present invention is to provide a pharmaceutical composition of dimercaprol, which contains dimercaprol and a natural product with a novel structure, and dimercaprol and the natural product can synergistically treat migraine. [0005] Above-mentioned purpose of the present invention is achieved by following technical scheme: [0006] A compound (I) having the followi...

Claims

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Application Information

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IPC IPC(8): A61K31/35A61K31/095C07D493/18A61P25/06
CPCA61K31/35A61K31/095A61K36/78C07D493/18
Inventor 陈露
Owner 陈露
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