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Preparation method of honeysuckle flower cold granules

A technology of honeysuckle and granules, which is applied in the field of preparation of honeysuckle granules, which can solve the problems that the preparation method of honeysuckle granules is difficult to meet the market demand, the core drug has a long heating time, and the loss of active ingredients of the drug, etc., so as to achieve good quality control and fluidity And the effect of good solubility and less loss of drug active ingredients

Inactive Publication Date: 2016-11-16
李时珍医药集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing Honeysuckle Ganmao Granules have unsatisfactory curative effect due to the composition and process, and there are shortcomings such as large loss of active ingredients in the preparation process.
At present, most of the honeysuckle granules used clinically have high sugar content. During the production process, the core drug is heated for a long time, which affects the quality of the drug. The whole production process takes a long time, the process is complicated, and the shape of the prepared particles is not ideal.
The preparation method of the existing Honeysuckle Ganmao Granules is difficult to meet the market demand

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0007] The invention provides a preparation method of honeysuckle cold granules. The steps include: weighing honeysuckle, forsythia, windproof, bellflower, and licorice, adding water to decoct, taking the decoction, filtering and concentrating, adding ethanol with the same volume as the concentrate, and statically Filter after setting, concentrate to a thick paste with a relative density of 1.20, add honeysuckle, forsythia, windproof, bellflower, licorice powdered sugar with a total mass of 54%-56% after cooling, and spray granulate, the process conditions of the spray granulate It is: spray rate 58-62g / min, atomization pressure 2.0-2.5kg, material temperature 78-82°C.

[0008] Spray granulation is carried out under special conditions according to the characteristics of the medicinal material, so that the material is fully and uniformly dried, and the time-consuming is significantly shortened, thereby reducing the heating time of the drug, maintaining the activity and efficacy ...

Embodiment 1

[0016] This embodiment provides a preparation method of Honeysuckle Ganmao Granules, the steps comprising:

[0017] Weigh 345.6g of honeysuckle, 345.6g of forsythia, 345.6g of Fangfeng, 345.6g of bellflower, and 172.8g of licorice, and decoct with water. The cooking time is 3 hours, and the second cooking time is 2 hours. Combine the decoction, filter and concentrate to 1700ml, then add ethanol equal to the volume of the concentrate, stir well, let it stand for 12 hours, then filter, recover ethanol from the filtrate, concentrate to a thick paste with a relative density of 1.20 (60°C), add 845g after cooling powdered sugar, spray granulation, the process conditions of the spray granulation are: spray rate 60g / min, atomization pressure 2.1kg, material temperature is 80 ℃, make 1000g, promptly get product honeysuckle cold granules.

[0018] The Honeysuckle Ganmao Granules prepared in this example have uniform and ideal particle shape, good fluidity and solubility, maintain the ...

Embodiment 2

[0020] This embodiment provides a preparation method of Honeysuckle Ganmao Granules, the steps comprising:

[0021] Weigh 345.6g of honeysuckle, 345.6g of forsythia, 345.6g of Fangfeng, 345.6g of Campanulaceae, 172.8g of licorice, and decoct with water. The cooking time is 3 hours, and the second cooking time is 2 hours. Combine the decoction, filter and concentrate to 1555ml, then add ethanol equal to the volume of the concentrate, stir well, let it stand for 12 hours, then filter, recover ethanol from the filtrate, concentrate to a thick paste with a relative density of 1.20 (60°C), add 850g after cooling powdered sugar, spray granulation, the process conditions of the spray granulation are: spray rate 62g / min, atomization pressure 2.5kg, material temperature is 82 ℃, make 1000g, promptly get product honeysuckle cold granules.

[0022] The Honeysuckle Ganmao Granules prepared in this example have uniform and ideal particle shape, good fluidity and solubility, maintain the a...

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PUM

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Abstract

The invention provides a preparation method of honeysuckle flower cold granules. The preparation method comprises the following steps of weighing honeysuckle flower, fructus forsythia, radix saposhnikoviae, radix platycodonis and liquorice root; adding water and decocting; taking a decoction solution, filtering and concentrating; then adding ethanol of which the volume is identical with that of a concentrated solution; standing, filtering and concentrating until thick paste of which the relative density is 1.20 is obtained; cooling and then adding powdered sugar which is 54 to 56 percent of a total mass of the honeysuckle flower, the fructus forsythia, the radix saposhnikoviae, the radix platycodonis and the liquorice root; spraying and granulating, wherein the process conditions of spraying and granulating are as follows: the spraying rate is 58 to 62g / min, the atomizing pressure is 2.0 to 2.5kg, and the temperature of the materials is 78 to 82DEG C. The preparation method of the honeysuckle flower cold granules is simple and controllable in process and high in yield; in addition, a prepared medicament is good in medicinal effect and ideal in granular shape; the loss of active ingredients of the medicine is less.

Description

technical field [0001] The invention relates to the technical field of cold treatment, in particular to a method for preparing honeysuckle granules. The honeysuckle granules prepared by the method have good medicinal efficacy and less loss of active ingredients of the medicine. Background technique [0002] Honeysuckle Ganmao Granule is a traditional Chinese medicine preparation made of honeysuckle, forsythia, windproof, bellflower, licorice and other medicinal materials. It has the effects of clearing away heat, relieving the exterior, and relieving the throat. It can be used for cold fever, headache, and sore throat. . [0003] The existing Honeysuckle Ganmao Granules have unsatisfactory curative effect due to the composition and process, and there are shortcomings such as large loss of active ingredients in the preparation process. At present, most of the honeysuckle granules used clinically have high sugar content. During the production process, the core drug is heated ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61K9/16A61P11/00A61P11/04A61P29/00
CPCA61K36/355A61K9/1623A61K9/1682A61K36/238A61K36/346A61K36/484A61K36/634A61K2236/331A61K2236/51A61K2236/53A61K2300/00
Inventor 陈普生
Owner 李时珍医药集团有限公司