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Compound sulfachloropyrazine sodium soluble powder and preparation method thereof

A sulfachloropyrazine sodium and soluble technology is applied in the compound sulfachloropyrazine sodium soluble powder and the field of preparation thereof, which can solve the problems of difficulty in achieving a therapeutic effect, uneven effect of compound drugs, etc. The effect of human food safety and drug cost reduction

Inactive Publication Date: 2016-11-23
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sulfachlorpyrazine sodium has good water solubility, but its synergists trimethoprim and ditrimethoprim are almost insoluble in water. The difference in water solubility of the two drugs will lead to uneven effect of the compound drug and it is difficult to achieve a good therapeutic effect

Method used

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  • Compound sulfachloropyrazine sodium soluble powder and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A compound sulfachlorpyrazine sodium soluble powder, each 100g soluble powder is made of the following components: sulfachlorpyrazine sodium 20g, synergist (trimethoprim) 4g, carrier I (polyethylene glycol 6000) 50g , Carrier II (polyvinylpyrrolidone K30) 4g, maltodextrin 10g, anhydrous glucose 12g.

[0030] Its preparation method comprises the following steps:

[0031] (1) Heat and melt the carrier I at 75-85°C to a liquid state, add synergist while it is hot, stir for 20 minutes, and dissolve to obtain system A;

[0032] (2) Mix maltodextrin and carrier II evenly, add to system A and mix, maintain the temperature at 90-100°C, and stir for 30 minutes. The system is uniform milky white without large particles, and system B is obtained;

[0033] (3) Spread the system B evenly, and solidify it in ice water for 4 hours under the environmental condition that the relative humidity is not higher than 40%, to obtain white solid C;

[0034] (4) Pulverize the solid C at room t...

Embodiment 2

[0037] A kind of compound sulfachlorpyrazine sodium soluble powder, the component in every 100g soluble powder is with embodiment 1.

[0038] Its preparation method is, adopt following steps:

[0039] a) Mix the synergist, carrier Ⅰ, carrier Ⅱ and maltodextrin, and after the mixture is hot-melt extruded, cool, crush, and pass through a 100-mesh sieve; the temperature of hot-melt extrusion in step a) is 75-85°C ;The cooling temperature is 0~4℃;

[0040] b) Pulverize sulfachlorpyrazine sodium and anhydrous glucose, pass through a 100-mesh sieve, and mix the undersize with the undersize in step a) in a three-dimensional mixer for 30 minutes.

Embodiment 3

[0042] A compound sulfachlorpyrazine sodium soluble powder, the components in every 100g soluble powder are sulfachlorpyrazine sodium 15g, synergist (ditrimethoprim) 3g, carrier I (polyethylene glycol 6000) 40g, Carrier II (polyvinylpyrrolidone K30) 2g, maltodextrin 5g, anhydrous glucose 35g.

[0043] Its preparation method is the same as that of Example 1, the difference being that in step 1) it is stirred for 30 minutes, and in steps (4) and (5) it is passed through an 80-mesh sieve.

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Abstract

A compound sulfachlorpyrazine sodium soluble powder, each 100g soluble powder is made of the following components: sulfachlorpyrazine sodium 15-25g, synergist 3-5g, carrier I 40-60g, carrier II 2-4g, malt paste The essence is 5-10g, and the balance is anhydrous glucose; the carrier I is polyethylene glycol 6000, polyethylene glycol 4000 or a mixture of the two, and the carrier II is polyvinylpyrrolidone. At the same time, the preparation method of the compound sulfachlorpyrazine sodium soluble powder is disclosed. This application adopts double water-soluble joint carrier materials to increase the solubility and dissolution rate of the synergist through solid dispersion technology. The preparation process is simple and feasible, and it is convenient for large-scale industrial production. Marketing.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a compound sulfachlorpyrazine sodium soluble powder and a preparation method thereof. Background technique [0002] Chicken coccidiosis is a common acute epidemic parasitic disease caused by one or more coccidia in chickens, which seriously endangers the development of poultry breeding industry and causes huge losses. The morbidity and mortality of chicks are high, and the growth of sick chicks is hindered and their weight gain is slow; adult chickens are mostly worm carriers, and their weight gain and egg production capacity are greatly reduced. [0003] Sulfachlorpyrazine sodium is a broad-spectrum antibacterial and anticoccidial drug. It has the characteristics of fast absorption in animals, wide distribution, strong antibacterial effect, long maintenance time, and does not affect the host's immunity to coccidia. It is widely used Used in the treatment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/635A61K47/34A61K47/32A61K47/36A61K47/26A61P33/02A61K31/505
CPCA61K9/146A61K9/145A61K31/505A61K31/635A61K2300/00
Inventor 吕凤霞郭建军杜雄伟班曼曼杨振豪李会芳刘联盟李小佳
Owner HENAN SOAR VETERINARY PHARMA
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