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Colonic tablet containing effective part of American cockroach and preparation method thereof

A technology of Periplaneta americana and effective parts, which is applied in the field of colon tablets and preparations of effective parts of Periplaneta americana, can solve the problems of drug efficacy reduction and degradation, and achieve the effects of maintaining drug efficacy, promoting absorption, and taking small doses

Inactive Publication Date: 2016-11-23
SOUTHWEST MEDICAL UNIVERISTY
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0008] In view of this, the technical problem to be solved by the present invention is to solve the problem that the active ingredients of the polypeptides of the American cockroach are easily degraded by enzymes and acids in the stomach, and the drug effect is reduced, and a colon-localized tablet of the effective part of the American cockroach is provided. and its preparation method

Method used

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  • Colonic tablet containing effective part of American cockroach and preparation method thereof
  • Colonic tablet containing effective part of American cockroach and preparation method thereof
  • Colonic tablet containing effective part of American cockroach and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment

[0036] One, the preparation of Periplaneta americana freeze-dried powder tablet

[0037] 1.1 Preparation of particles

[0038] 1.1.1 Screening and dosage investigation of excipients for granulation

[0039] (1) filler

[0040] Because the lyophilized powder of Periplaneta americana extract has high viscosity, strong hygroscopicity, and contains a small amount of oil, it is difficult to granulate. Therefore, it is considered to add fillers with low hygroscopicity to reduce its hygroscopicity. Microcrystalline cellulose is stable in nature, has good compressibility, strong moisture resistance, and the compressed tablet has relatively high hardness. At the same time, it also has the functions of adhesion and disintegration; calcium hydrogen phosphate is often used as a traditional Chinese medicine rich in oils and strong The absorbent for hygroscopic drugs has stable properties, no hygroscopicity, and good fluidity. Therefore, it is proposed to use microcrystalline cellulose an...

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Abstract

The invention discloses a colonic tablet containing an effective part of American cockroach and a preparation method thereof. The colonic tablet comprises American cockroach freeze-dried powder, a filler, a disintegrating agent, a wetting agent and a lubricating agent, wherein a mass ratio of the American cockroach freeze-dried powder to filler is 1:1.5; the amount of the lubricating agent is 0.3% of the total amount of the American cockroach freeze-dried powder and filler; and the amount of the disintegrating agent is 3% of the total amount of the American cockroach freeze-dried powder and filler. According to the colonic tablet containing the effective part of American cockroach disclosed by the invention, due to a colon coating technology, the drug effect is maintained, and absorption is promoted, so that the drug bioavailability is improved, bad odor of the drug is masked, the stability of the preparation is guaranteed, and reduction of the treatment effect and adverse reaction caused by quality differences of the preparations are reduced. According to the preparation form of the tablet, the colonic tablet is small in administration dose, rapid in absorption, stable in quality, convenient to carry, easy to preserve and particularly suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular, it relates to a colon tablet of effective parts of Periplaneta americana and a preparation method thereof Background technique [0002] Cancer is the second largest killer of human beings next to cardiovascular disease, seriously endangering human health, and has gradually become a major social public health problem. Western medicine still mainly treats tumors with surgery, radiotherapy and chemotherapy, with severe and extensive side effects, which lead to the deterioration of the patient's body condition and the decline of the quality of life. Most patients give up treatment because they cannot bear it, and even die from overtreatment. Traditional Chinese medicine plays an immeasurable role in the treatment of tumors. Malignant tumors belong to the categories of "cancer", "rock", "swelling" and "accumulation" in traditional Chinese medicine. The ...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K9/30A61K47/38A61K47/02A61K47/10A61K47/32A61P35/00A61P37/04A61P9/00A61P17/00
CPCA61K9/2009A61K9/2013A61K9/2054A61K9/2846A61K35/63
Inventor 张丹田吉朱伟刘明华陈斯玮余昕廖芳傅超美
Owner SOUTHWEST MEDICAL UNIVERISTY
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