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Traditional Chinese medicine composition for radiotherapy and chemotherapy vomiting reaction reliving and synergetic cancer inhibition

A combination, radiotherapy and chemotherapy technology, applied in the directions of drug combination, digestive system, anti-tumor drugs, etc., can solve the problems of large prescription and high dosage, and achieve the effect of maintaining appetite, enhancing tumor suppressor effect, and reducing vomiting reaction.

Inactive Publication Date: 2016-11-23
陈文星
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there are also many traditional Chinese medicine compositions for alleviating chemotherapy emesis, but there are many disadvantages such as large prescriptions and large dosages.

Method used

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  • Traditional Chinese medicine composition for radiotherapy and chemotherapy vomiting reaction reliving and synergetic cancer inhibition
  • Traditional Chinese medicine composition for radiotherapy and chemotherapy vomiting reaction reliving and synergetic cancer inhibition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: preparation of dry extract of composition of the present invention

[0013] Take 160g of ginger, 80g of astragalus, 120g of magnolia bark, 100g of salvia miltiorrhiza, 40g of centella asiatica, 100g of atractylodes rhizome, and 120g of hawthorn, chop and mix them separately, and then add water to decoct. After boiling for half an hour, collect the decoction. The residue is decocted with water, so decocted three times, and the decoction liquid is combined. Concentrate the decoction to make a dry extract.

Embodiment 2

[0014] Embodiment 2: Research on the antiemetic effect of the composition of the present invention

[0015] Effect of the composition of the present invention on pica behavior in rats.

[0016] 1. Experimental materials

[0017] 1.1 Samples: 1. The dry extract of the pharmaceutical composition prepared in Example 1 is prepared into a solution with a certain concentration just before use. Preparation method: Take an appropriate amount of the pharmaceutical composition, weigh it accurately, add a certain amount of distilled water, ultrasonically for 10 minutes, and stir until fully dissolved and suspended; ②Ondansetron injection (specification: 4mL·8mg -1 ; Shandong Qilu Pharmaceutical Co., Ltd.; batch number: 9120815AT). 1.2 Reagents: ① cisplatin (powder injection; specification: 10 mg; batch number: 9131256HD; Shandong Qilu Pharmaceutical Co., Ltd.); ② kaolin (analytical pure, prepared by referring to the method of Takeda N et al., mixing kaolin with 1% gum arabic to prepare...

Embodiment 3

[0026] Embodiment 3: Research on the antitumor effect of the composition of the present invention

[0027] 1. Materials and Reagents

[0028] 1.1 Sample:: 1. The dry extract of the pharmaceutical composition prepared in Example 1 is prepared into a solution with a certain concentration just before use. Preparation method:

[0029] Take an appropriate amount of the pharmaceutical composition, weigh it accurately, add a certain amount of distilled water, ultrasonicate for 10 minutes, and stir until the suspension is fully dissolved; ②Cisplatin (powder injection; specification: 10mg; batch number: 9131256HD; Shandong Qilu Pharmaceutical Co., Ltd.) .

[0030] 1.2 Reagents: RPMI-1640, DMEM (Gibco), calf serum (Vicent, 20130118), Trypsin (Amresco).

[0031] 1.3 Cell line: H22 mouse liver cancer cell line, provided by Shanghai Cell Institute of Chinese Academy of Sciences.

[0032] 1.4 Animals: C57BL / 6 mice, 18-22g, half male and half male, provided by the Comparative Medicine Ce...

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Abstract

The invention relates to traditional Chinese medicine composition for radiotherapy and chemotherapy vomiting reaction reliving and synergetic cancer inhibition. The traditional Chinese medicine composition is prepared from the following main raw materials in parts by weight: 10-16 parts of ginger, 5-10 parts of astragalus membranaceus, 8-12 parts of magnolia officinalis, 6-12 parts of salvia miltiorrhiza, 4-8 parts of centella asiatica, 5-10 parts of atractylodes macrocephala and 6-12 parts of hawthorn. The preparation for reliving the vomiting reaction caused by radiotherapy and chemotherapy is prepared from natural traditional Chinese medicines, and has a good reliving function on the vomiting reaction caused by radiotherapy and chemotherapy of cancer, the cancer inhibition functions of chemotherapeutic drugs can be enhanced in a synergetic manner, and the appetite can be improved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for alleviating the vomiting reaction of radiotherapy and chemotherapy and synergistically suppressing cancer. Background technique [0002] Vomiting is the most common reaction in clinical cancer patients after chemotherapy and radiotherapy. And this kind of vomiting often affects the patient's normal eating. In severe cases, it may even cause dehydration, electrolyte imbalance, etc., disrupt the patient's work and rest routine, and then affect the recovery of the body; what's more, the patient can't bear this pain, causing the patient to give up treatment. . Although there are many drugs currently used clinically for the treatment of vomiting, there are chemical drugs such as ondansetron and granisetron. There are some other side effects, which also limit their use to a certain extent. [0003] Traditional Chinese medici...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P1/08A61P35/00
Inventor 陈文星
Owner 陈文星