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Preparation method of degradation controllable PLLA (poly-L-lactic acid)/PGA (poly glycolic acid) composite membrane

A technology of composite film and degradation time, which is applied in the field of PLLA/PGA composite film preparation, can solve the problems of inability, poor biocompatibility of mulch film, and poor compatibility of mixtures, etc.

Inactive Publication Date: 2016-11-23
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Previous patent applications have provided many composite materials with controllable degradation. For example, patent 20880439.8 provides a biodegradable mulch film with a polyethylene integrated structure. However, this mulch film is not biocompatible and cannot be used as a human body. Biodegradable materials
There are also films made directly by solvent evaporation, but the compatibility between the mixtures made by this method is very poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0014] (1) Weigh 450g PLLA and 50g PGA slices with a precision balance, then mix the slices and dry them in a vacuum drum, using a two-stage drying method, pre-crystallization before drying. First, the temperature is raised from room temperature to 65~70°C for 3~4 hours to pre-crystallize, and then the temperature is slowly raised to 110°C for 12 hours, so that the moisture content of the slices can be lower than 0.05%.

[0015] (2) Pass the dried slices through a twin-screw extruder to prepare composite slices. Set up 10 heating temperature zones for the twin-screw extruder: 1-2 zone 165~170°C, 3-4 zone 171-174°C, 5-6 zone 175-177°C, 7-8 zone 178-182°C, 9- Zone 10 185-190°C.

[0016] (3) Then dissolve the compound slices in the Erlenmeyer flask containing methylene chloride solution, adjust the water bath constant temperature oscillator to 25°C, and then put the Erlenmeyer flask into the water bath constant temperature oscillator, PLLA and PGA will slowly dissolve In dichlo...

Embodiment approach 2

[0021] (1) Weigh 250g PLLA and 250 PGA slices with a precision balance, then mix the slices and dry them in a vacuum drum, using a two-stage drying method, pre-crystallization before drying. First, the temperature is raised from room temperature to 65~70°C for 3~4 hours to pre-crystallize, and then the temperature is slowly raised to 110°C for 12 hours, so that the moisture content of the slices can be lower than 0.05%.

[0022] (2) Pass the dried slices through a twin-screw extruder to prepare composite slices. Set up 10 heating temperature zones for the twin-screw extruder: 1-2 zone 165~170°C, 3-4 zone 171-174°C, 5-6 zone 175-177°C, 7-8 zone 178-182°C, 9- Zone 10 185-190°C.

[0023] (3) Then dissolve the compound slices in the Erlenmeyer flask containing methylene chloride solution, adjust the water bath constant temperature oscillator to 25°C, and then put the Erlenmeyer flask into the water bath constant temperature oscillator, PLLA and PGA will slowly dissolve In dichlo...

Embodiment approach 3

[0028] (1) Weigh 50g PLLA and 450g PGA slices with a precision balance, then mix the slices and dry them in a vacuum drum, using a two-stage drying method, pre-crystallization before drying. First, the temperature is raised from room temperature to 65~70°C for 3~4 hours to pre-crystallize, and then the temperature is slowly raised to 110°C for 12 hours, so that the moisture content of the slices can be lower than 0.05%.

[0029] (2) Pass the dried slices through a twin-screw extruder to prepare composite slices. Set up 10 heating temperature zones for the twin-screw extruder: 1-2 zone 165~170°C, 3-4 zone 171-174°C, 5-6 zone 175-177°C, 7-8 zone 178-182°C, 9- Zone 10 185-190°C.

[0030] (3) Then dissolve the compound slices in the Erlenmeyer flask containing methylene chloride solution, adjust the water bath constant temperature oscillator to 25°C, and then put the Erlenmeyer flask into the water bath constant temperature oscillator, PLLA and PGA will slowly dissolve In dichlo...

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Abstract

The invention relates to a preparation method of a degradation time controllable PLLA (poly-L-lactic acid) / PGA (poly glycolic acid) composite membrane. The preparation method includes the steps: weighing PLLA and PGA by a precision balance and uniformly mixing the PLLA and the PGA according to needed degradation time; increasing the temperature to reach 65-70 DEG C and drying mixture for 3-4 hours to perform pre-crystallization; continuing increasing the temperature to reach 110 DEG C and drying the pre-crystallization mixture for 12 hours; extruding the mixture by a double-screw extruder, adding the PLLA and PGA mixture treated in the second step into dichloromethane solution, and completely dissolving the PLLA and PGA mixture; preparing the membrane by a scraper coating machine according to a solvent evaporation method. The preparation method has the advantage that the degradation rate of the composite membrane can be set between that of the PLLA and the PGA.

Description

technical field [0001] The invention relates to a method for preparing a PLLA / PGA composite film with controllable degradation time. Background technique [0002] PLLA is a kind of polymer polyester material with abundant raw materials and renewable sources. It is widely used in the medical field, especially when making surgical sutures, PLLA can be reduced to CO 2 and H 2 O, the intermediate product lactic acid is also a normal product of metabolism in the body, no need to remove the stitches, avoiding the pain of removing stitches, and is favored by many people. However, there is a problem when PLLA is applied to surgical sutures, that is, the degradation cycle of PLLA does not match the speed of wound healing. When the wound healing time is short, PLLA fails to degrade, which will lead to infection. When the wound healing time is long, PLLA has been degraded, the strength has decreased, and a second suture is required. [0003] Therefore, it is necessary to prepare a b...

Claims

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Application Information

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IPC IPC(8): C08J5/18C08L67/04B29C47/92B29C48/92
CPCC08J5/18B29C48/92B29C2948/92704C08J2367/04C08J2467/04C08L67/04C08L2201/06C08L2203/02C08L2203/16C08L2205/025
Inventor 刘淑强吴改红许安高志刚
Owner TAIYUAN UNIV OF TECH
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