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Effect study method and application of melatonin in prediction of ovarian reserve and IVF-ET (in-vitro fertilization and embryo transfer) outcome

A technology for IVF-ET and ovarian reserve, applied in the field of melatonin in predicting ovarian reserve and in vitro fertilization-embryo transfer outcome, can solve the problems of no unified consensus and guidelines, and achieve the effect of simple operation and improved success rate

Inactive Publication Date: 2016-11-30
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Problems solved by technology

[0012] There is no consensus and guidelines for the definition or diagnosis of normal ovarian response

Method used

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  • Effect study method and application of melatonin in prediction of ovarian reserve and IVF-ET (in-vitro fertilization and embryo transfer) outcome
  • Effect study method and application of melatonin in prediction of ovarian reserve and IVF-ET (in-vitro fertilization and embryo transfer) outcome
  • Effect study method and application of melatonin in prediction of ovarian reserve and IVF-ET (in-vitro fertilization and embryo transfer) outcome

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Embodiment Construction

[0048] The specific implementation manner of the present invention will be further described in detail according to the specific examples below.

[0049] The present invention collects the data of 61 female patients receiving in vitro fertilization (IVF) or intracytoplasmic sperm microinjection technology-embryo transfer treatment for research. According to their response to ovarian stimulation, they were divided into 3 groups: ovarian low response group, normal group and high response group mainly by age, number of retrieved eggs, and anti-Müllerian hormone (AMH) value.

[0050] Collect the follicle fluid of 61 women. The method is: under the guidance of vaginal ultrasound, the first tube of follicle fluid is extracted from the dominant follicle (19-24mm in diameter) of each patient through follicle puncture. The follicle fluid must not be diluted or polluted by blood , all follicular fluid is extracted from 8:00 am to 11:00 am. After the oocytes were separated, the follicul...

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Abstract

The invention discloses an effect study method of melatonin in prediction of ovarian reserve and IVF-ET (in-vitro fertilization and embryo transfer) outcome. The method includes: collecting basic clinical data of 61 females, and dividing the 61 females into three groups, namely a poor ovarian response group, a normal ovarian response group and a high ovarian response group mainly through age, retrieved oocyte number and anti-mullerian hormone value according to the stimulus response of the ovaries; collecting follicular fluid of the 61 females, adopting melatonin radioimmunoassay to determine melatonin concentration in the follicular fluid of the 61 females, and analyzing the levels of the melatonin concentration and other clinical data in the poor ovarian response group, the normal ovarian response group and the high ovarian response group; analyzing the levels of relevant data of in-vitro fertilization outcome in the poor ovarian response group, the normal ovarian response group and the high ovarian response group, and verifying relevance of the melatonin concentration and IVF-ET outcome; verifying relevance of the melatonin level and ovarian reserve. Through detection of melatonin concentration in the follicular fluid, ovarian reserve and IVF-ET outcome are predicted.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a research method and application of melatonin in predicting ovarian reserve and in vitro fertilization-embryo transfer (IVF-ET) outcome. Background technique [0002] A woman's ovarian reserve consists of the number and quality of oocytes in the ovary and can be used to assess a woman's reproductive potential. Although the outcome of each infertility patient receiving in vitro fertilization-embryo transfer (IVF-ET) treatment varies greatly and is extremely difficult to predict, routine assessment of their ovarian reserve is beneficial to formulate an individualized treatment plan in order to increase In vitro fertilization-embryo transfer (IVF-ET) success rates. Serum markers commonly used to reflect ovarian reserve are serum anti-Müllerian hormone (AMH) and basal follicle-stimulating hormone (bFSH) concentrations. However, serum anti-Müllerian hormone (AMH) is not correlated with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/53A61B5/00
CPCG01N33/5308A61B5/4306A61B5/4325
Inventor 张丛童婧
Owner RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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