Preparation method of drug-loaded polylactic acid surgery suture line
A technique of surgical suture and polylactic acid, which is applied in the fields of surgery, pharmaceutical formulations, and pharmaceutical sciences, can solve the problems of difficult to achieve, low drug loading and sudden drug release, and achieves good dispersibility, good drug sustained-release function, and dispersibility. stable effect
Active Publication Date: 2016-12-07
TAIYUAN UNIV OF TECH
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- Application Information
AI Technical Summary
Problems solved by technology
At present, some people have prepared polylactic acid surgical sutures with certain antibacterial effects by adding antibacterial agents in the spinning process, but the drug loading is low and the problem of sudden drug release is serious, so it is difficult to achieve the expected effect
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0011] The following examples are used to further illustrate the present invention, but are not limited to the following examples.
[0012] Step 1. Preparation of drug-loaded microspheres
[0013] Take 20 mL of dichloromethane and 0.8 g of polylactic acid particles into the flask, place the flask on a magnetic stirrer and adjust the speed to 800 r / min to form a polylactic acid solution.
[0014] Adjust the speed of the magnetic stirrer to 1200r / min, and use a syringe to slowly and evenly inject 3 mL of gentamicin sulfate into the high-speed stirring polylactic acid solution, and stir at high speed for 10 minutes to form colostrum.
[0015] Take 1.5g gelatin and 0.3g polyoxyethylene sorbitan monooleate into a 500mL three-necked flask, measure and add 400mL deionized water, place the three-necked flask on a magnetic stirrer and stir at 1000r / min. Until all the substances are completely dissolved, it is used as the outer water phase.
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Abstract
The invention relates to a polylactic acid surgery suture line, in particular to a preparation method of a drug-loaded polylactic acid surgery suture line. The preparation method has the advantages that polylactic acid drug-loaded microspheres are loaded to the polylactic acid surgery suture line by turbid liquid made from starch acetate, polyethylene glycol and olive oil, and the turbid liquid has stable dispersity and is poisonless and harmless; the obtained drug-loaded surgery suture line does not have or seldom has burst drug release effect, and has a good slow drug release function; effective drug concentration can last for 50 days, and various mechanical properties of the processed surgery suture line are hardly damaged.
Description
Technical field [0001] The invention relates to a polylactic acid surgical suture thread, in particular to a preparation method of a drug-loaded polylactic acid surgical suture thread. Background technique [0002] Polylactic acid fiber, also known as corn fiber, is made from corn and other grain materials through fermentation, polymerization, and spinning. Its crystallinity, transparency and heat resistance are similar to polyester fiber. Polylactic acid fiber and its copolymers have good biocompatibility and biodegradability, and can be gradually degraded into carbon dioxide and water in the human body, and are non-toxic and non-accumulating to the human body. At the same time, polylactic acid fiber also has considerable mechanical strength and durability and good processing performance. The fiber made from it has high tensile strength and good flexibility. It is a good absorbable suture material. [0003] Polylactic acid can absorb bacteria in the fibrous gaps of surgical sutur...
Claims
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IPC IPC(8): A61L17/14A61L17/12A61L17/00
CPCA61L17/005A61L17/12A61L17/145A61L2300/232A61L2300/404A61L2300/622A61L2400/12
Inventor 刘淑强吴改红张晓芳王妮许安郭红霞邵芬娟卢建军
Owner TAIYUAN UNIV OF TECH