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Technology for identifying capsules on basis of terahertz time-domain spectral imaging

A terahertz time-domain and spectral imaging technology, which is used in material analysis, measurement devices, instruments, etc. by optical means, which can solve the problem that the enzyme inhibition method is not very accurate, the requirements of instrument operators are high, and the chromatography method cannot realize online detection. And other issues

Inactive Publication Date: 2016-12-07
CHINA JILIANG UNIV
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Problems solved by technology

[0005] Existing detection methods for drugs include spectroscopy, chromatography, enzyme inhibition and other methods. Chromatography cannot achieve online detection, and the requirements for instrument operators are very high. Enzyme inhibition is not very accurate and errors occur frequently

Method used

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  • Technology for identifying capsules on basis of terahertz time-domain spectral imaging
  • Technology for identifying capsules on basis of terahertz time-domain spectral imaging

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Embodiment Construction

[0018] The steps of the capsule detection method based on terahertz time-domain spectral imaging are as follows: (1) Select standard samples of capsule drugs such as norfloxacin capsules, ofloxacin capsules, and pefloxacin mesylate capsules, and put them into drying oven for drying;

[0019] (2) Detect the air and multiple capsule standard samples using a terahertz time-domain spectroscopy system, so as to obtain a terahertz time-domain spectrum as a reference signal;

[0020] (3) Store the obtained refractive index spectrum and absorption spectrum of the capsule into the database in the background of the THz online detection system, click the "Import Data File" button of the detection system to establish a three-dimensional characteristic spectrum library of the original data, and maintain each type Descriptive characterization of substances;

[0021] (4) Select the capsule sample to be tested. Here, taking norfloxacin capsules as an example, under the specified conditions o...

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Abstract

The invention discloses a technology for identifying packaged capsules on the basis of terahertz time-domain spectral imaging technologies. Medicines mainly include capsule medicines such as norfloxacin, amoxicillin and cefradine. The technology approximately includes steps of (1), preparing standard samples of a plurality of groups of capsule medicines and eliminating different types of environmental noise and influence of different types of environments to obtain terahertz absorption spectra of the various samples; (2), selecting optical parameters of the various standard samples in terahertz wave band effective intervals and creating three-dimensional characteristic spectrum databases of the optical parameters; (3), arranging effective optical parameters of the to-be-detected medicines in the previously created three-dimensional characteristic spectrum databases and comparing spectrogram absorption peaks of the effective optical parameters so as to classify and identify the medicines and judge whether the to-be-detected medicines are pure or not. The technology has the advantages that medicine components in the capsules can be efficiently and accurately identified by the aid of the technology, and accordingly the technology has a broad application prospect in the fields of medicine analysis, medicine detection and the like.

Description

technical field [0001] The invention relates to a capsule detection method based on terahertz time-domain spectral imaging, and belongs to the technical field of terahertz time-domain spectral detection. Background technique [0002] In the field of medicine, because some drugs are strongly irritating to the esophagus and gastric mucosa, or have a bad taste, are easy to volatilize, and are easily decomposed by saliva in the mouth, the drugs are put into capsules, which not only protects the properties of the drugs from being destroyed, It also protects the digestive organs and respiratory tract. [0003] In recent years, terahertz technology has developed rapidly, and has broad application prospects in communication, detection, spectroscopy and other fields. Terahertz (THz) pulse, also known as terahertz ray and terahertz radiation, refers to electromagnetic waves with a frequency between 100GHz-10THz and a wavelength within the range of 3mm-30um (1THz=1012Hz) between micro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/3586G01N21/41
CPCG01N21/3586G01N21/41
Inventor 陈锡爱张松
Owner CHINA JILIANG UNIV
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