Crystallization purification method for paclitaxel

Abstract

The invention discloses a method for preparing a crude paclitaxel product prepared from a specific three-component system consisting of dichloromethane, acetone and alkane through crystallization purification and having a structure as shown in the following formula which is described in the specification. The method comprises the following steps: 1) dissolving the crude paclitaxel product in a mixed solution of dichloromethane and acetone; 2) adding alkane into the mixed solution drop by drop so as to allow paclitaxel to be precipitated; and 3) carrying out filtering and drying so as to obtain a high-purity paclitaxel product. The method provided by the invention has excellent purifying effect and can prepare paclitaxel with HPLC purity of 99% or above; the method has a wide application scope and exerts substantial purifying effect on almost all the impurities including specific impurities hard to purify, such as 7-epitaxol; the method is simple to operate, only needs simple reaction tanks and is suitable for large-scale production; and the method is high in purification yield, wherein crystallization yield is 92% or above.

Description

technical field [0001] The present invention relates to the crystallization field of compounds; specifically, the present invention relates to a paclitaxel crystallization purification method. Background technique [0002] Due to the change of living environment and lifestyle, as well as the aging of the population, the increase of living pressure and other objective factors, cancer has become one of the main factors of human death in the world. my country has a large population, the incidence of cancer continues to rise, and the number of patients is increasing day by day. Cancer has become the number one cause of death in my country. The global sales of antineoplastic drugs are rising, maintaining a steady and high-speed growth every year. [0003] Taxane antineoplastic drugs are microtubule depolymerization inhibitors, and their mechanism of action is completely different from other chemically synthesized antineoplastic agents or plant anticancer drugs that have been mar...

AI Technical Summary

Problems solved by technology

[0008] However, the purification effect of the current crystallization methods in the prior art is not good, and it is often necessary to repeat 3 to 4 times to obtain qualified pure products, and for specific impurities, such as 7-epitaxol, there is basically no purification effect; The use of chromatographic columns for final purification and purification results in high requirements for equipment. Therefore, a large amount of organic solvents are used in the operation process, which poses a huge hidden danger to environmental protection and safety. Moreover, the capacity of purification using chromatographic columns is also extremely limited.

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