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Satiety maintaining agent and method for maintaining feeling of satisfaction

A technology for satiety and allulose, which is applied in the field of satiety-sustaining agents or satiety-sustaining agents, can solve problems such as large side effects and gastrointestinal dysfunction, and achieve health improvement, appetite reduction, and satiety-sustaining Effect

Inactive Publication Date: 2016-12-21
JICHI MEDICAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since it acts on the whole brain as a serotonin agonist or a dopamine agonist, it not only suppresses appetite, but also causes serious side effects such as abnormal blood pressure, gastrointestinal dysfunction, and neuropsychiatric symptoms.

Method used

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  • Satiety maintaining agent and method for maintaining feeling of satisfaction
  • Satiety maintaining agent and method for maintaining feeling of satisfaction
  • Satiety maintaining agent and method for maintaining feeling of satisfaction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] The "food intake reducing effect" of D-psicose was confirmed by the following test in fasted mice.

[0084] experiment method

[0085] As experimental animals, C57BL / 6J male mice were used. The mice were prepared to be domesticated in their respective cages for more than a week to adapt to the environment. After fasting for 16 hours from 18:00 on the day before the experiment, each test liquid was administered orally or intragastrically or intraperitoneally. In each administration, physiological saline (10 mL / kg) was administered as a control group, and D-psicose (0.3 g / kg, 1 g / kg, 3 g / kg) was administered as a test group. ). The concentration of each test solution at this time was 0.3%, 10%, and 30%, respectively. Each solution was administered at 9:45, and mice were allowed to freely ingest CE-2 feed (a nutritionally balanced general feed for mice, manufactured by Japan CLEA) at 10:00, and measured for 0.5 hour, 1 hour, and 2 hours. Food intake over time after ...

Embodiment 2

[0093] In order to deny that the above-mentioned food intake reducing effect is caused by the unpleasant feeling or disgust associated with the ingestion of D-psicose, a conditional taste aversion test was carried out for oral administration of D-psicose.

[0094] experiment method

[0095] As experimental animals, the same C57BL / 6J male mice as in the previous experiments were used. The mice kept in their respective cages were given only two bottles of water within 2 hours from 10:00 to 12:00 for 5 consecutive days to comply with the water restriction schedule. On day 6, 0.15% saccharin solution was provided for 30 minutes, after which lithium chloride (3 mmol / kg) was intraperitoneally administered to allow learning of taste aversion to saccharin solution (conditioning). Similarly, a control group orally administered physiological saline (10 mL / kg) and a test group orally administered psicose (1 g / kg or 3 g / kg) were prepared. On the seventh day, the aforementioned water r...

Embodiment 3

[0104] The following experiments were conducted to verify the involvement of vagal afferents in the D-psicose-induced reduction in food intake.

[0105] experiment method

[0106] The activation of "vagal afferent nerve" and its projection object "nucleus solitary tract" caused by oral administration of D-psicose was analyzed based on the expression level of c-Fos. The expression of c-Fos, a marker of neuronal activation, was analyzed. c-Fos is a kind of immediate early gene, which is a nuclear protein whose expression level increases with the activation of nerves, and can be used as a marker of nerve activation. In addition, the cell bodies of the vagal afferent nerve are all concentrated in the inferior ganglion of the vagus nerve, projecting to the peripheral side (heart, lung, digestive tract, pancreas, liver, etc.) and central side (nucleus of the solitary tract of medulla) bipolar nerves.

[0107] As experimental animals, C57BL / 6J male mice were used, and they were ...

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Abstract

[Problem] To provide a satiety maintaining agent or method for maintaining a feeling of satisfaction which is capable of maintaining satiety so as to reduce dietary intake by an individual, thereby preventing and improving a condition, such as obesity, that is caused by overeating. [Solution] A satiety maintaining agent that comprises D-psicose as an active ingredient and a method for maintaining a feeling of satisfaction by consuming D-psicose. [Effect] Satiety can be maintained even though a rise in blood glucose level after a meal is suppressed. Thus, a useful means for maintaining satiety can be provided for people who worry about their blood glucose level or who are health-oriented.

Description

technical field [0001] The present invention relates to a satiety-sustaining agent or a satiety-sustaining method capable of sustaining satiety by taking D-psicose in the body, and relates to a method for reducing food intake of an individual by sustaining satiety The amount, that is, to reduce energy intake, and then seek to prevent and improve satiety-sustaining agents or satiety-sustaining methods that can prevent and improve obesity and other morbid conditions caused by overeating. Background technique [0002] The prevention and improvement of obesity are very important for the maintenance and improvement of health. Obesity is one of the morbid conditions resulting from excessive accumulation of sugar or lipid in the form of neutral fat in the subcutaneous fat tissue or tissues surrounding the organ due to excessive food intake, and the hypertrophic internal organ fat synthesizes and secretes TNF Adipocyte cytokines (adipocytokines) such as -α have adverse effects on g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7004A61P3/04A23L33/20
CPCA23V2002/00A23L33/30A61K31/7004A61P3/04A61P3/10A23V2200/332A23V2250/60A23L33/125A61K9/0053
Inventor 矢田俊彦岩崎有作木村友纪大隈一裕
Owner JICHI MEDICAL UNIVERSITY
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