A kind of preparation method of nano pearl powder rich in active peptide
A technology of nano-pearl powder and active peptides, which is applied in the direction of powder transportation and medical raw materials derived from molluscs. It can solve the problems of small molecule active peptides, loss of pearl medicinal value, and poor activity. The effect of human body's absorption and utilization and content increase
Active Publication Date: 2019-08-23
伊纱曼妮广州生物科技有限公司
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Problems solved by technology
Pearl grains are insoluble in water. They are usually ground into powder by traditional methods for taking or external use. They are not easily absorbed by the human body. Usually, they can only absorb about 29%, and their activity is poor.
In modern times, people use modern science and technology to grind or hydrolyze it to make full use of it, and produce two types of water-insoluble pearl powder and water-soluble pearl powder: 1. The thickness of pearl powder is used as the standard for water-insoluble pearl powder. There are mainly ordinary pearl powder and superfine (nanometer) pearl powder, etc., but the absorption efficiency can only be limited; 2. Water-soluble pearl powder generally refers to the production of pearl powder that is treated with acid or acid and enzyme. However, the calcium carbonate in the pearl (powder) completely destroys the strict and highly ordered natural structure composed of calcium carbonate crystals in the organic matrix framework, which may be soluble in water and easily absorbed by calcium lactate. It is closely related to the medicinal value of pearls; at the same time, the current production process of water-soluble pearl powder generally pursues a high degree of proteolysis, and uses enzymes to hydrolyze proteins into amino acids as much as possible, resulting in extremely small molecule active peptides that are very medicinal to the human body. less, it may lose the original medicinal value of pearls
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[0025] In a 25-liter enzymolysis reaction tank, add 5 kg of nano-pearl powder, add 10 liters of deionized water, and stir at 60 rpm to form a paste; 2 PO 4 -The bromelain solution prepared by NaOH (pH=7.2) phosphate buffer solution, under the stirring state of 60 rpm, enzymolyzes at 55°C for 6 hours, then heats up to 100°C, and keeps it warm for 10 minutes to inactivate bromelain; then press Pearl powder weight 0.5‰ add 0.2mol / L Na 2 HPO 4 -NaH 2 PO 4 (pH=7.0) papain solution prepared by phosphate buffer solution, under the stirring state of 60 rpm, enzymolyze at 65°C for 6 hours, then heat up to 100°C, inactivate and remove papain for 10 minutes; at 65°C Low temperature vacuum drying, and finally, supersonic jet pulverizer to get nano pearl powder rich in active peptides.
[0026] Above 0.05mol / L KH 2 PO 4 -NaOH (pH=7.2) phosphate buffer, 0.2mol / L Na 2 HPO 4 -NaH 2 PO 4(pH=7.0) the preparation of phosphate buffer, bromelain solution and papain solution is as follow...
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The invention discloses a preparation method of nano pearl powder containing rich active peptides. The preparation method comprises the following steps: S1, taking nano pearl powder as a raw material; adding de-ionized water and stirring to form paste; S2, adding a bromelain solution prepared from a phosphatic buffer solution; stirring and carrying out enzymolysis; then heating to remove bromelain; S3, adding a papain solution prepared from the phosphatic buffer solution into the nano pearl powder without the bromelain; stirring and carrying out enzymolysis; then heating to remove papain; S4, after the secondary enzymolysis, decompressing at low temperature and drying in vacuum; finally, crushing by adopting an supersonic airflow crusher, so as to obtain the nano pearl powder containing the rich active peptides. According to the preparation method provided by the invention, an organic matrix framework (mainly comprising concliolin) in pearls can be hydrolyzed into soluble low-molecular-weight active peptides which have proper molecular weight and are easily absorbed by human bodies, instead of being hydrolyzed into amino acids without specific nutrient value; meanwhile, a highly ordered natural structure in the pearl powder becomes porous and can be more easily absorbed and utilized by human bodies.
Description
technical field [0001] The invention relates to a preparation method of nano pearl powder, which belongs to the technical field of pearl powder preparation, in particular to a preparation method of nano pearl powder rich in active peptides. Background technique [0002] Pearls are calcium carbonate-containing mineral beads produced by the endocrine action of pearl oysters and nacre molluscs. They are composed of a large number of tiny aragonite crystals. Pearl has important application value. On the one hand, pearl is a precious organic gemstone with high market value, and has bred pearl cultivation and related industries; on the other hand, as a traditional Chinese medicine, it has always attracted people's attention. It is rich in nutrients and life-source substances, has strict and orderly structure characteristics and is rich in nano-mineral particles, so it has important medicinal value. Relevant studies have shown that the composition and microstructure of pearls are ...
Claims
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IPC IPC(8): A61K9/14A61K35/618
CPCA61K9/143A61K35/618
Inventor 尹国荣黄迪南
Owner 伊纱曼妮广州生物科技有限公司