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Preparation method of stretch-proof drug-loaded polylactic acid surgical suture

A technology of surgical suture and polylactic acid, which is applied in the field of biomedicine, can solve the problems of limited preparation process, unsatisfactory mechanical properties of products, and limited application of absorbable sutures, and achieve the effect of high molecular weight and good tensile strength

Inactive Publication Date: 2017-01-04
侯英
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, my country's absorbable sutures still face three major problems: (1) The preparation process is limited, and the mechanical properties of the products are not satisfactory
For these reasons, the clinical application of absorbable sutures in my country is still relatively limited.

Method used

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  • Preparation method of stretch-proof drug-loaded polylactic acid surgical suture

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Experimental program
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Effect test

Embodiment 1

[0021] A method for preparing stretch-resistant drug-loaded polylactic acid surgical sutures, dispersing drug-loaded hollow silicon dioxide submicron spheres in an aqueous solution of stretch-resistant polylactic acid, and spinning the drug-loaded hollow silicon dioxide Silicon submicron spheres are embedded in stretch-resistant polylactic acid fibers to make stretch-resistant drug-loaded polylactic acid surgical sutures; the preparation steps of the stretch-resistant polylactic acid include:

[0022] 1) Using lactic acid as a raw material, dehydration and refining are carried out under vacuum conditions to obtain lactic acid oligomers;

[0023] 2) mixing the lactic acid oligomer obtained in step 1) with a catalyst, adding it to a reaction vessel, and heating and reacting under vacuum conditions to obtain a polylactic acid intermediate product;

[0024] 3) Add chain extender TDI to the reaction vessel in step 2), and heat the reaction under vacuum conditions to obtain high mol...

Embodiment 2

[0034] A method for preparing stretch-resistant drug-loaded polylactic acid surgical sutures, dispersing drug-loaded hollow silicon dioxide submicron spheres in an aqueous solution of stretch-resistant polylactic acid, and spinning the drug-loaded hollow silicon dioxide Silicon submicron spheres are embedded in stretch-resistant polylactic acid fibers to make stretch-resistant drug-loaded polylactic acid surgical sutures; the preparation steps of the stretch-resistant polylactic acid include:

[0035] 1) Using lactic acid as a raw material, dehydration and refining are carried out under vacuum conditions to obtain lactic acid oligomers;

[0036] 2) mixing the lactic acid oligomer obtained in step 1) with a catalyst, adding it to a reaction vessel, and heating and reacting under vacuum conditions to obtain a polylactic acid intermediate product;

[0037] 3) Add chain extender TDI to the reaction vessel in step 2), and heat the reaction under vacuum conditions to obtain high mol...

Embodiment 3

[0047] A method for preparing stretch-resistant drug-loaded polylactic acid surgical sutures, dispersing drug-loaded hollow silicon dioxide submicron spheres in an aqueous solution of stretch-resistant polylactic acid, and spinning the drug-loaded hollow silicon dioxide Silicon submicron spheres are embedded in stretch-resistant polylactic acid fibers to make stretch-resistant drug-loaded polylactic acid surgical sutures; the preparation steps of the stretch-resistant polylactic acid include:

[0048] 1) Using lactic acid as a raw material, dehydration and refining are carried out under vacuum conditions to obtain lactic acid oligomers;

[0049] 2) mixing the lactic acid oligomer obtained in step 1) with a catalyst, adding it to a reaction vessel, and heating and reacting under vacuum conditions to obtain a polylactic acid intermediate product;

[0050] 3) Add chain extender TDI to the reaction vessel in step 2), and heat the reaction under vacuum conditions to obtain high mol...

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Abstract

The invention relates to a preparation method of stretch-proof drug-loaded polylactic acid surgical suture. The preparation method comprises the steps of dispersing drug-loaded hollow silicon dioxide submicro-spheres into a stretch-proof polylactic acid water solution, and embedding the drug-loaded hollow silicon dioxide submicro-spheres into stretch-proof polylactic acid fibers by using a spinning method so as to prepare the stretch-proof drug-loaded polylactic acid surgical suture. Stretch-proof polylactic acid is prepared by the following steps: (1) carrying out dehydration refining on lactic acid which is taken as a raw material under the vacuum condition to obtain a lactic acid oligomer; (2) mixing the lactic acid oligomer obtained in the step (1) with a catalyst, adding the obtained mixture into a reaction vessel, and carrying out a heating reaction under the vacuum condition to obtain a polylactic acid intermediate product; (3) adding a chain extender TDI into the reaction vessel in the step (2), and carrying out a heating reaction under the vacuum condition to obtain high molecular weight polylactic acid.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a preparation method of stretch-resistant drug-loaded polylactic acid surgical suture. Background technique [0002] At present, the surgical sutures used clinically in China are mainly divided into two types: non-absorbable sutures and absorbable sutures. Non-absorbable sutures include nylon, polypropylene, and polyethylene. These materials are used as surgical sutures with high tensile strength and low tissue response, but the disadvantages are that they are difficult to knot, easy to detach, cannot be degraded and absorbed, and need to be removed. Absorbable sutures include cashmere thread, polyglycolide, chitin, collagen fibers, etc. Advanced absorbable sutures should have strong tensile strength, good handling performance, uniform and stable material, no antigenicity, and low tissue reaction, which is better than non-absorbable sutures. At present, my country's absorbable sutur...

Claims

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Application Information

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IPC IPC(8): A61L17/14A61L17/12A61L17/00
CPCA61L17/12A61L17/005A61L17/14A61L2300/622
Inventor 侯英
Owner 侯英