Bone cement with high heat generating efficiency

A technology of bone cement and thermal efficiency, applied in the field of biomedicine, can solve the problems of low heating efficiency, side effects, and large amount of magnetic nanoparticles, and achieve the effect of reducing the amount of addition and high heating efficiency

Inactive Publication Date: 2017-01-04
CAPITAL NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the disadvantages of low heating efficiency, large amount of magnetic nanoparticles, high product of frequency (f) and strength (H) of the magnetic field during use, and potential side effects on the human body in the bone cement in the prior art, we propose a Bone cement with high thermogenic efficiency

Method used

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  • Bone cement with high heat generating efficiency
  • Bone cement with high heat generating efficiency
  • Bone cement with high heat generating efficiency

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] This embodiment relates to a bone cement with high heat production efficiency, the bone cement raw material is PMMA, and 0.5% magnetic nanoparticle Zn is added therein 0.7 Fe 2.3 o 4 ;

[0037] The present embodiment also relates to the preparation method of this magnetic bone cement, comprising the following steps:

[0038] 1) Place PMMA, MMA and magnetic nanoparticles at 23°C and a relative humidity of 40%-50% for more than 2h,

[0039] 2) Weigh 1.99g of PMMA powder and place it in a crucible, weigh 0.01g of magnetic nanoparticles, and dissolve the magnetic nanoparticles in 1ml of MMA solution, ultrasonically disperse the particles uniformly in the solution, and then dissolve the magnetic nanoparticles The mixed solution was injected into a crucible filled with PMMA powder and mixed evenly.

[0040] 3) Transfer the mixed mixture to a cylindrical mold with a diameter of 6 mm and a height of 12 mm for about 10 minutes, after it is completely polymerized, demould.

...

Embodiment 2

[0044] Compared with Example 1, the difference is that the magnetic nanoparticles are Zn 0.5 mn 0.5 Fe 2 o 4 , its addition amount is 0.5%.

[0045] Present embodiment also relates to the preparation method of this bone cement, comprises the steps:

[0046] 1) Place PMMA, MMA and magnetic nanoparticles at 23°C and a relative humidity of 40%-50% for more than 2h,

[0047] 2) Weigh 1.99g of PMMA powder and place it in a crucible, weigh 0.01g of magnetic nanoparticles, and dissolve the magnetic nanoparticles in 1ml of MMA solution, ultrasonically disperse the particles uniformly in the solution, then place the magnetic nanoparticles containing The mixed solution was injected into a crucible filled with PMMA powder and mixed evenly.

[0048] 3) Transfer the mixed mixture to a cylindrical mold with a diameter of 6 mm and a height of 12 mm for about 10 minutes, after it is completely polymerized, demould.

[0049] The present embodiment also relates to the specific application...

Embodiment 3

[0052] Compared with Example 1, the difference is that the magnetic nanoparticles are Zn 0.7 Fe 2.3 o 4 , its addition amount is 1%.

[0053] Present embodiment also relates to the preparation method of this bone cement, comprises the steps:

[0054] 1) Place PMMA, MMA and magnetic nanoparticles at 23°C and a relative humidity of 40%-50% for more than 2h,

[0055] 2) Weigh 1.99g of PMMA powder and place it in a crucible, weigh 0.02g of magnetic nanoparticles, and dissolve the magnetic nanoparticles in 1ml of MMA solution, ultrasonically disperse the particles uniformly in the solution, then place the magnetic nanoparticles containing The mixed solution was injected into a crucible filled with PMMA powder and mixed evenly.

[0056] 3) Transfer the mixed mixture to a cylindrical mold with a diameter of 6 mm and a height of 12 mm for about 10 minutes, after it is completely polymerized, demould.

[0057] The present embodiment also relates to the specific application of this...

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Abstract

The embodiment of the invention relates to a bone cement with a high heat generating efficiency. The bone cement is prepared from, by mass, 0.2-1.0% of magnetic nano-partilces MxFe3-xO4, wherein in the magnetic nano-partilces MxFe3-xO4, M is one or a mixture of several of cobalt, manganese and zinc, and the value range of X is 0.1-1. In the bone cement, the magnetic nano-partilces with the high heat generating efficiency are added, high heating efficiency can be achieved with a small adding amount when the product of the frequency (f) and the strength (H) of a magnetic field is smaller than 5*10<9> Am-1s-1, the effect of killing tumor cells can be achieved, and the heating efficiency is within the safe range capable of being borne by the human body.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a bone cement with high heat production efficiency. Background technique [0002] Bone is the third most frequent site of malignant tumor metastasis after lung and liver [1], about 70% of prostate cancer and breast cancer patients, 30%-40% of kidney cancer, thyroid cancer patients and 10% of gastrointestinal cancer patients Patients with tumors are prone to bone metastases [2]. Bone tumors often cause severe pain, and the most common complication is pathological fracture, which limits the patient's activities and seriously affects the quality of life [3]. Traditional conservative treatment requires patients to immobilize the affected limb and rest in bed for several months, but prolonged bed rest will bring great inconvenience to the patient's life, greatly reduce the quality of life of the patient, and also greatly increase the risk of dementia in the elderly [...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/16A61L27/12A61L27/50A61L27/54
CPCA61L27/025A61L27/12A61L27/16A61L27/50A61L27/54A61L2430/02C08L33/12
Inventor 贺淑莉刘义灏俞翔张力
Owner CAPITAL NORMAL UNIVERSITY
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