Unlock instant, AI-driven research and patent intelligence for your innovation.

A method for extracting high-purity naringenin from pomelo peel

A technology for grapefruit peel and naringenin, which is applied in the field of extracting high-purity naringenin, can solve the problems of high price of organic acids, waste of raw materials, and high production costs, and achieve the effects of less impurity content, lower production costs, and higher yields

Active Publication Date: 2018-07-06
HUNAN HUACHENG BIOTECH
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the highest hydrolysis rate of naringin in this method is only 86.9%, and at least 13% of naringin is not hydrolyzed completely, which causes a lot of waste of raw materials, and the organic acid is expensive and the production cost is too high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Water extraction: crush 300kg of dried pomelo peel, add to 9000kg of water, extract at 80°C for 6 hours, and filter to obtain naringin extract;

[0033] (2) Membrane filtration and concentration: filter the naringin extract obtained in step (1) with a ceramic membrane with a pore size of 200 nm, and concentrate the ceramic membrane filtrate at 95°C to obtain 650 kg of naringin concentrate (measured as naringin The content is 1.622%, and the extraction yield of naringin is 94.98%);

[0034](3) Pressurized hydrolysis: Add 1.1 kg of sulfuric acid to the 650 kg of naringin concentrated solution obtained in step (2), hydrolyze for 3 hours at 130 ° C and a pressure of 0.3 MPa, cool to room temperature, filter, and water the filtered The cake was washed until neutral, and the filter cake was dried to obtain 4.98 kg of crude naringenin (the measured naringenin content was 95.30%, and the yield of naringenin obtained by hydrolysis of naringin was 91.36%);

[0035] (4) Refin...

Embodiment 2

[0038] (1) Water extraction: crush 500kg of dried pomelo peel, add it to 7500kg of water, extract at 85°C for 5 hours, and filter to obtain naringin extract;

[0039] (2) Membrane filtration and concentration: filter the naringin extract obtained in step (1) with a ceramic membrane with a pore size of 400 nm, and concentrate the ceramic membrane filtrate at 100°C to obtain 750 kg of naringin concentrate (measured as naringin content of 2.368%, the extraction yield of naringin is 96%);

[0040] (3) Pressurized hydrolysis: Add 3.7kg of hydrochloric acid to the 750kg of naringin concentrate obtained in step (2), hydrolyze for 5 hours at 120°C and a pressure of 0.2MPa, cool to room temperature, filter, and water The cake was washed to neutral, and the filter cake was dried to obtain 8.26 kg of crude naringenin (the measured naringenin content was 94.62wt%, and the yield of naringenin hydrolyzed was 89.93%);

[0041] (4) Refining: Dissolve 8.26 kg of crude naringenin obtained in s...

Embodiment 3

[0044] (1) Water extraction: crush 400kg of dried pomelo peel, add it to 8000kg of water, extract at 90°C for 6 hours, and filter to obtain naringin extract;

[0045] (2) Membrane filtration and concentration: filter the naringin extract obtained in step (1) with a ceramic membrane with a pore size of 500 nm, and concentrate the ceramic membrane filtrate at 105°C to obtain 300 kg of naringin concentrate (measured as naringin The content of naringin is 4.687%, and the extraction yield of naringin is 95%);

[0046] (3) Pressurized hydrolysis: Add 2.22 kg of phosphoric acid to the 300 kg of naringin concentrated solution obtained in step (2), hydrolyze for 5 hours at 110°C and a pressure of 0.1 MPa, cool to room temperature, filter, and filter with water The cake was washed until neutral, and the filter cake was dried to obtain 6.72 kg of crude naringenin (the measured naringenin content was 94.12wt%, and the yield of naringenin hydrolyzed was 91.32%);

[0047] (4) Refining: Dis...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
pore sizeaaaaaaaaaa
Login to View More

Abstract

A method for extracting high-purity naringenin by taking pumelo peel as the raw material comprises the steps of (1) water extraction: dried pumelo peel is smashed, heated, extracted and filtered, and a naringin extract is obtained; (2) membrane filtration and concentration: the naringin extract is filtered by a ceramic membrane and concentrated, and a naringin concentrated solution is obtained; (3) pressurization hydrolyzation: acid is added, heating, pressurization hydrolyzation, cooling to room temperature and filtering are performed, a filter cake is washed by water to be neutral, the filter cake is dried, and a naringenin crude product is obtained; (4) refining: the naringenin crude product is heated and dissolved in a water solution with lower alcohol, cooling crystallization and drying are performed, the filter cake is dried, and a naringenin fine product is obtained. The naringenin fine product prepared with the method is in a white crystal powder form, the purity of the obtained naringenin can be as high as 99.67%, the impurity content is low, and the final yield of the naringenin is larger than 85%; according to the method, the naringin is not required to be separated or purified, the yields of the naringin and the naringenin are high, the production cost is low, and the method is suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting naringenin, in particular to a method for extracting high-purity naringenin from pomelo peel. Background technique [0002] Naringenin is an aglycone of naringin, which is widely found in Rutaceae plants. [0003] Naringenin has a variety of pharmacological properties, including antibacterial, anti-inflammatory, free radical scavenging, antioxidant, cough and expectorant, blood lipid lowering, anticancer, antitumor, antispasmodic and choleretic, prevention and treatment of liver diseases, inhibition of platelet aggregation , anti-atherosclerosis and other effects, showing rich resource advantages and huge potential utilization value. Naringenin has been widely used in medicine, food and other fields. [0004] At present, the method for obtaining a large amount of naringenin is mainly to obtain naringenin by extraction method, and then hydrolyze naringin to obtain naringenin; the main steps of industria...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/32C07D311/40
CPCC07D311/32C07D311/40
Inventor 李伟龙伟岸黄华学
Owner HUNAN HUACHENG BIOTECH