An electrochemical analyte sensing system and method capable of self-correcting interference signals

Abstract

The invention discloses an electrochemical analyte sensing system capable of self-correcting interference signals. The system comprises a sensor, a direct-current voltage power supply component, a current measuring component, an alternating-current impedance measuring component, a circuit changeover switch, a controller, a data processing and communication component and a power supply. A blank electrode with the size the same as that of a working electrode is added, and the interference signals are eliminated by means of signal subtraction. The alternating-current impedance measuring component is added, and the working state of the sensor is judged according to system impedance outputted by the alternating-current impedance measuring component. The influence of interferents and measuring environment change on analyte signal generation can be effectively eliminated, and effectiveness and accuracy of measuring signals are ensured by the sensor during working.

Description

technical field [0001] The invention relates to the technical field of analyte sensing systems, in particular to an electrochemical analyte sensing system and method capable of self-correcting interference signals. Background technique [0002] The electrochemical sensor is a widely used analyte sensor. Its basic working principle is to convert the chemical analyte in the measurement sample into a detectable electrical signal through an electrochemical reaction by applying a suitable voltage or current to the working electrode of the sensor. . There are currently various types of biosensors on the market for multiple analytes, of which the most studied and common biosensor is the amperometric (amperometric) glucose sensor, which is very important for the successful control of glucose levels in diabetes of. [0003] The traditional amperometric glucose sensor uses glucose oxidase immobilized on the sensor electrode to oxidize the glucose in the sample to generate gluconic a...

AI Technical Summary

Problems solved by technology

For the elimination of interference signals, the application of interference suppression diaphragms is not only high in manufacturing costs and complicated in process, but also only effective for a specific type of interference

For example, by adjusting the pore size, only the interferences larger than the analyte molecules can be excluded, but the interferences with the same size or smaller as the analyte molecules cannot be excluded; similarly, the charge exclusion method can only exclude the charges that are similar to the analyte. Opposite interferences without exclusion of neutral or identically charged interferences with the analyte

For the elimination of the influence of the measurement environment signal, the absolute numerical analysis and the rate of change analysis of the sensor electrical signal can only exclude extreme cases, but cannot distinguish or exclude the influence of the measurement environment change with a small magnitude

In this case, the accuracy of the sensor will still be affected, so regular calibration is required to adjust the correlation between the current signal and the concentration of the analyte to ensure accuracy, which also increases the difficulty of using the sensor and the convenience of use become worse

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