Method for determining six aromatic amine compounds in cigarette mainstream smoke by using online SPE/LC-MS/MS
A technology of cigarette mainstream smoke and aromatic amines, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve problems such as human error, tedious and time-consuming processing, achieve high precision, reduce sample analysis interference, and reduce pollution.
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Embodiment 1
[0032] 1. Sample preparation
[0033] The balanced and screened cigarettes are smoked according to the standard conditions specified in ISO 3308:2000, and 4 Cambridge filters (φ44mm) are used to capture the particulate matter in the mainstream smoke of 20 cigarettes (each Cambridge filter captures 5 Particulate matter in the mainstream smoke of cigarettes); an absorption bottle pre-filled with 25 mL of 2% formic acid solution is connected to the back of the trap through a hose to collect gaseous matter.
[0034] Remove the absorption bottle that collects the gas phase and add 0.25 mL mixed internal standard (d 9 -O-toluidine, d 3 -O-anisidine, d 6 -2,6-Dimethylaniline, d 7 -1-Aminonaphthalene and d 9 -4-aminobiphenyl), mix well, and directly enter Online SPE / LC-MS / MS analysis.
[0035] Fold the Cambridge filter with 20 cigarette mainstream smoke particles into a 250mL conical flask, add 1.0mL mixed internal standard and 100mL 2% formic acid solution (extract solution), and ultrasonic...
Embodiment 2
[0070] The Kentucky reference cigarette 3R4F was pumped in accordance with the standard conditions specified in ISO 3308:2000, and the particulate matter of 5 cigarettes was collected per Cambridge filter, and the gaseous matter was collected in an absorption bottle containing 25 mL of 2% formic acid solution.
[0071] Then, the sample processing and analysis were performed according to the steps and conditions described in Example 1. Six parallel experiments and five-day determinations were performed. The relative standard deviations of the determination of each compound were between 2.50-5.52% and 2.24-6.69, indicating that the method has good reproducibility and stability.
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