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Construction method of skin pigmentation animal model

A skin pigmentation and animal model technology, applied in medical science, veterinary instruments, etc., can solve problems such as inability to meet modeling requirements, inconvenient microscope observation and instrument detection modeling conditions, and prone to erythema on the skin.

Inactive Publication Date: 2017-02-01
THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention provides a method for constructing an animal model of skin pigmentation, which overcomes the deficiencies of the prior art, and can effectively solve the problem of erythema, molting, etc. Skin damage is not convenient for microscope observation and instrument detection to determine the modeling conditions, which can no longer meet the existing modeling requirements

Method used

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  • Construction method of skin pigmentation animal model
  • Construction method of skin pigmentation animal model

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Experimental program
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Effect test

Embodiment 1

[0028] Embodiment 1, the construction method of this animal model of skin pigmentation, is carried out according to the following steps: the first step, selects the test guinea pig; hair, so that the skin on the back of the guinea pig is fully exposed; the third step is to irradiate the exposed skin of the guinea pig with ultraviolet rays once every other day, and irradiate 2 to 10 times, and the energy of each irradiation is 50mJ·cm-2 to 500mJ ·cm-2, to obtain animal models of skin pigmentation after irradiation. Ultraviolet phototherapy equipment can be used to irradiate ultraviolet rays; the skin on the back has better tolerance than other parts, and is smooth and easy to apply and administer. Irradiate once every other day, and irradiate 2 to 10 times. The energy of each irradiation is 50mJ cm-2 to 500mJ cm-2. The conditions are mild, and the energy range of irradiation is suitable for skin tolerance; Collateral damage caused by model animals; too few times of irradiation...

Embodiment 2

[0029] Embodiment 2, the construction method of this animal model of skin pigmentation, is carried out according to the following steps: the first step, selects the test guinea pig; hair, so that the skin on the back of the guinea pig is fully exposed; the third step is to irradiate the exposed skin of the guinea pig with ultraviolet rays once every other day, 2 times or 10 times, and the energy of each irradiation is 50mJ cm-2 or 500mJ ·cm-2, to obtain animal models of skin pigmentation after irradiation.

Embodiment 3

[0030] Embodiment 3, as an optimization of the above embodiment, the guinea pigs tested were brown guinea pigs. Since the distribution of melanocytes and melanosomes in hair follicles and epidermis in brown-yellow guinea pigs is similar to that in humans (especially Asians), it can be used as a melanogenic model carrier to reflect the skin condition after pigmentation more realistically. most widely.

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Abstract

The invention relates to the technical field of a construction method of an animal model and provides a construction method of a skin pigmentation animal model. The construction method comprises: step 1, selecting a guinea pig to be tested; step 2, shaving long hairs and removing short hairs; step 3, irradiating by ultraviolet rays to obtain the skin pigmentation animal model. By selecting the ultraviolet rays to radiate a back skin of the guinea pig to be tested and taking change conditions of skin melanin and melanocytes as indexes, the skin pigmentation animal model is established through determining an optimal irradiation dosage and irradiation time; the skin is not scorched and the skin has no erythema, molting, swelling and blisters; the skin pigmentation animal model is convenient for microscopic observation and instrument detection; a pigmentation resisting effect of herba cistanche phenylethanoid glycoside nano-emulsion is observed and inspected through appearance evaluation and histopathology; compared with the prior art, physiological statuses of skins of people can be relatively really simulated after skin pigmentation, and references are provided for researches of novel pigmentation-resisting drugs, novel preparations and whitening and sun-screen cosmetics.

Description

technical field [0001] The invention relates to the technical field of a method for constructing an animal model, and relates to a method for constructing an animal model of skin pigmentation. Background technique [0002] Human skin contains a variety of pigments, such as yellow pigment, brown pigment and melanin, and these pigments are generally referred to as "melanin". The color of the skin is affected by many factors, among which the distribution of melanin in the dermis plays a decisive role in the color of the skin. The synthesis and deposition of normal melanin has the functions of protecting the skin, resisting ultraviolet radiation and preventing the internal tissues of the body from overheating. The defect of any link or the influence of a certain factor will cause the disorder of melanin synthesis or transportation process, resulting in abnormal changes such as hyperpigmentation, too little or lack of skin melanin, which will lead to the occurrence of a series o...

Claims

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Application Information

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IPC IPC(8): A61D7/00
CPCA61D7/00
Inventor 杨建华胡君萍许欢欢居博伟吴姗姗朱丹丹曹丹丹向雪滢俞婧
Owner THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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