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A kind of traditional Chinese medicine preparation and its preparation and application

A technology of traditional Chinese medicine preparations and drugs, which is applied in the field of traditional Chinese medicine composition and its application in the preparation of drugs for the treatment of chronic aplastic anemia, which can solve the problems of no application reports, etc., to improve clinical curative effect, improve the quality of life, and improve hematopoiesis microenvironment effect

Active Publication Date: 2019-10-08
ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the application of the compound and its preparations in chronic aplastic anemia

Method used

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  • A kind of traditional Chinese medicine preparation and its preparation and application
  • A kind of traditional Chinese medicine preparation and its preparation and application
  • A kind of traditional Chinese medicine preparation and its preparation and application

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Embodiment 1 Chinese medicine preparation 1

[0025] Chinese medicine composition 306g, formula: 30 parts of Rehmannia glutinosa, 30 parts of Rehmannia glutinosa, 6 parts of cinnamon, 20 parts of Salvia miltiorrhiza, 20 parts of angelica, 20 parts of Cuscuta seed, 20 parts of psoralen, 20 parts of fairy spleen, 30 parts of heterophylla, Polygonum multiflorum 15 parts, 15 parts of Radix Paeoniae Rubra, 15 parts of Dan Cortex, 15 parts of Poria cocos, 15 parts of Atractylodes macrocephala, 30 parts of Chinese yam, 6 parts of licorice.

[0026] The preparation method of the traditional Chinese medicine composition: mix the raw materials according to the formula amount, add 3 to 5 times the weight of water, soak for 1 hour, decoct and boil for 30 minutes, and keep the traditional Chinese medicine decoction. Add the same amount of water to the dregs of the medicine, continue to decoct and boil for 15 minutes, remove the dregs of the medicine, combine the decoction of the tra...

Embodiment 2

[0027] Embodiment 2: Chinese medicine preparation 2

[0028] Chinese medicine composition 218g, formula: 20 parts of Rehmannia glutinosa, 15 parts of Rehmannia glutinosa, 4 parts of cinnamon, 10 parts of Salvia miltiorrhiza, 10 parts of angelica, 15 parts of Cuscuta, 20 parts of psoralen, 20 parts of fairy spleen, 30 parts of heterophylla, Polygonum multiflorum 10 parts, 10 parts of red peony, 9 parts of paeonol, 10 parts of Poria cocos, 12 parts of Atractylodes macrocephala, 30 parts of Chinese yam, 3 parts of licorice.

[0029] The preparation method of the traditional Chinese medicine composition: mix the raw materials according to the formula amount, add 3 to 5 times the weight of water, soak for 1 hour, decoct and boil for 30 minutes, and keep the traditional Chinese medicine decoction. Add the same amount of water to the dregs of the medicine, continue to decoct and boil for 15 minutes, remove the dregs of the medicine, combine the decoction of the traditional Chinese me...

Embodiment 3

[0030] Embodiment 3: Chinese medicine preparation 3

[0031] Chinese medicine composition 145g, formula: 10 parts of Rehmannia glutinosa, 10 parts of Rehmannia glutinosa, 3 parts of cinnamon, 10 parts of Salvia miltiorrhiza, 10 parts of angelica, 10 parts of Cuscuta seed, 10 parts of psoralen, 10 parts of fairy spleen, 9 parts of heterophylla, Polygonum multiflorum 10 parts, 8 parts of Radix Paeoniae Rubra, 9 parts of Dan Cortex, 9 parts of Poria cocos, 9 parts of Atractylodes macrocephala, 15 parts of Chinese yam, 3 parts of licorice.

[0032] The preparation method of the traditional Chinese medicine composition: mix the raw materials according to the formula amount, add 3 to 5 times the weight of water, soak for 1 hour, decoct and boil for 30 minutes, and keep the traditional Chinese medicine decoction. Add the same amount of water to the dregs of the medicine, continue to decoct and boil for 15 minutes, remove the dregs of the medicine, combine the decoction of the traditi...

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Abstract

The invention discloses a traditional Chinese medicine preparation, and preparation and application thereof. The traditional Chinese medicine preparation is prepared from the following raw materials in proportion by mass: 10 to 30 parts of prepared rehmannia roots, 10 to 30 parts of radix rehmanniae, 3 to 6 parts of cortex cinnamomi, 10 to 20 parts of radix salviae miltiorrhizae, 10 to 20 parts of radix angelicae sinensis, 10 to 20 parts of seeds of Chinese dodder, 10 to 20 parts of fructus psoraleae, 10 to 20 parts of herba epimedii, 9 to 30 parts of radix pseudostellariae, 10 to 15 parts of radix polygoni multiflori preparata, 8 to 15 parts of radix paeoniae rubra, 9 to 15 parts of cortex moutan, 9 to 15 parts of poria cocos, 9 to 15 parts of bighead atractylodes rhizome, 15 to 30 parts of Chinese yam and 3 to 6 parts of liquorice roots. The traditional Chinese medicine preparation has the advantages that the bone marrow mesenchymal stem cell multiplication of an AA patient can be promoted; by activating an SDF-1 / CXCR4-PI3K / AKT signal path, the aplastic anemia MSCs function restoration can be effectively promoted; the mRNA expression of MSCs VEGF, SDF-1, CXCR4 and Akt of mice can be effectively improved; the hemopoietic microenvironment can be improved.

Description

[0001] (1) Technical field [0002] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition and its application in preparing medicine for treating chronic aplastic anemia. [0003] (2) Background technology [0004] Aplastic anemia (AA) is a bone marrow hematopoietic failure disease, clinically manifested as anemia, hemorrhage and infection, of which chronic aplastic anemia accounts for about 80%. At present, the main treatment options for chronic aplastic anemia mainly include immunosuppressants (such as cyclosporine) and androgen to stimulate hematopoiesis. Some patients stop treatment due to the economic burden and drug side effects caused by long-term medication, resulting in relapse of the disease. , the overall prognosis is poor, and the quality of life of patients is low. Traditional Chinese medicine has been used in AA for more than 50 years, and has clear advantages in regulating immunity, stimul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61P7/06
Inventor 叶宝东吴迪炯沈一平林圣云胡致平高雁婷武利强沈建平周郁鸿
Owner ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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