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A device for a medical treatment of a sclera

A scleral, medical technique used in the field of substance application and radiation systems to address issues such as unsatisfactory treatment methods

Inactive Publication Date: 2017-02-15
UNIV LEIPZIG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Individual technical methods for substance application or for radiation of areas / tissues are always simplified for their particular use and do not meet the needs of our therapeutic methods

Method used

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  • A device for a medical treatment of a sclera
  • A device for a medical treatment of a sclera
  • A device for a medical treatment of a sclera

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0369] Example 1: Surgery in Rabbit Experiments

[0370] To perform riboflavin / blue light collagen cross-linking, animals were anesthetized by intramuscular injection of ketamine hydrochloride (50 mg / kg body weight; ketamine 5%, Deutschland, Ulm, Germany) together with xylazine hydrochloride (10 mg / kg body weight; kg body weight; Long Peng; Bayer, Leverkusen, Germany). To maintain anesthesia, ketamine hydrochloride (25 mg / kg body weight) and xylazine hydrochloride (5 mg / kg body weight) were injected intramuscularly. Only the right eye underwent treatment, whereas the contralateral untreated eye served as the sole control. In order to avoid damage to the cornea during the operation, use Eye ointment (Gerhardmann, Berlin, Germany) was applied to the left eye. In addition, oxybucaine (conjuncain) was used for local anesthesia of the right eye. After a temporary canthotomy, the conjunctiva is incised at the edge of the heterochromia to open Tenon's space. Subsequently, the...

Embodiment 2

[0371] Example 2: Measurement of Riboflavin Penetration in Scleral Tissue

[0372] Figure 11 The average duration of total tissue penetration of riboflavin in scleral flaps from various species is shown. Penetration time was calculated by applying riboflavin to one side of the scleral tissue flap, and the gross appearance on the opposite side was monitored for maximal fluorescence by fluorescence microscopy. Riboflavin takes approximately 30-40 minutes to penetrate the human sclera compared to the 10-20 minutes it takes riboflavin to penetrate the rabbit sclera. Freeze / thaw scleral tissue was used for this examination; however, results were similar to freshly isolated (ie, non-frozen) tissue.

[0373] Figure 12 Spectral light transmittance characteristics of scleral tissue from various species are shown. Only about 0.5-1% of light (up to 500nm wavelength) penetrates scleral tissue in all species. The application of riboflavin further reduces the transmission at wavele...

Embodiment 3

[0375] Example 3: Results of scleral crosslinking in different species

[0376] Figure 14: Light microscopy of tissue semi-thin sections (0.5 μm thickness, stained with toluidine blue) to compare the size and structure of scleral tissue from various species. Scale bars in A (cynomolgus) sclera are valid for all sclera segments in A and show differences in thickness in the posterior portion of the sclera. B shows tissue sections at higher magnification to reflect structural differences. Histological examination revealed large structural similarities between rabbit and human sclera as well as differences compared to other species. Scale bars in B (macaque) sclera are valid for all sclera segments in B.

[0377] Figure 15 : Comparison of morphological properties of acutely isolated (A) versus frozen / thawed (B-D) sclera tissue with (C and D) and without (A and B) cross-linking treatment. Photomicrographs show histological semi-thin sections of scleral tissue visualized by l...

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Abstract

The invention provides a device for a medical treatment of a sclera, the device comprising a single applicator connected to a shaft, wherein the applicator is configured to be placed into the Tenon's space; the applicator has a first surface, wherein the first surface of the applicator is superficially contactable to the surface of an area of the sclera so as to superficially cover said area; and the applicator comprises a single optical outlet connected to a single optical guiding element extending from a proximal end of the shaft to the single distal optical outlet at the first surface of the applicator, the optical guiding element being configured for guiding electromagnetic waves towards the optical outlet, wherein the optical guiding element is configured to guide electromagnetic waves of a wavelength adapted for thermal treatment of the sclera by protein coagulation.

Description

technical field [0001] The present invention generally relates to a substance application and irradiation system (SAIS-Spot) for locally defined and precise treatment of scleral tissue of the eye. Accordingly, the present invention relates to medical devices for the application of substances (and / or radiation) to a patient during ophthalmic surgery. In particular, the present invention relates to devices for medical treatment of the sclera. Background technique [0002] In previous years, collagen cross-linking (by applying riboflavin and UV-A light radiation ) (Wollensak et al., American Journal of Ophthalmology 2003, 135:620-627). In the anterior part of the eye, the application of substances and light is significantly easier since this part is directly accessible without surgery. [0003] Collagen crosslinking of the sclera (sclera crosslinking) for the treatment of progressive myopia is new and has so far only been tested in animal experiments (Iseli et al., Journal o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F9/008
CPCA61F9/0017A61F9/008A61F9/00821A61F2009/00853A61F2009/00865
Inventor 汉斯·彼得·伊谢利迈克·弗兰克彼得·维德曼
Owner UNIV LEIPZIG
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