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Metoclopramide oral film and preparation method thereof

A technology of metoclopramide and oral film, which is applied in the field of metoclopramide oral film and its preparation, can solve the problems of pain in injections, difficulty in self-administration, poor compliance, etc., and achieve brittle High fragmentation, avoid first-pass effect, and good compliance

Inactive Publication Date: 2017-02-22
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the dosage forms of metoclopramide that have been marketed at home and abroad include tablets, injections, and nasal sprays. However, the above-mentioned preparations have limitations, such as tablet patients, especially children, have difficulty swallowing, and injections are painful and difficult to control. Drug administration, poor compliance, not easy to carry

Method used

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  • Metoclopramide oral film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Weigh 0.80g of PVA05-88, add 6ml of pure water, swell for 30min, heat in a water bath at 85°C to form a clear PVA solution; weigh 0.40g of CMC-Na, disperse it on the surface of 6ml of pure water, wait for it to sink and dissolve naturally, and let it stand overnight to obtain a viscous CMC-Na solution; mix the two solutions to obtain a composite film-making glue. Weigh 0.10g of ALG-Na dissolved in 5ml of pure water to obtain a viscous solution, and add it into the film-making glue. Weigh 0.20g of metoclopramide and add 3ml of pure water to dissolve, add 0.10g of aspartame to the solution, stir and mix, pour into the compound film-making glue, then add 0.20ml of glycerin, stir, ultrasonic, and let stand Defoaming. That is, the drug-containing mixed glue is obtained.

[0031] Sprinkle a small amount of release agent talcum powder on the board in advance, and evenly cover the whole board. Pour an appropriate amount of film slurry on the glass plate, adjust the height of...

Embodiment 2

[0033] Weigh 0.66g of PVA05-88, add 6ml of pure water, swell for 30min, heat in a water bath at 85°C to form a clear PVA solution; weigh 0.33g of CMC-Na, disperse it on the surface of 6ml of pure water, wait for it to sink and dissolve naturally, and let it stand overnight to obtain a viscous CMC-Na solution; mix the two solutions to obtain a composite film-making glue. Weigh 0.10g of ALG-Na dissolved in 5ml of pure water to obtain a viscous solution, and add it into the film-making glue. Weigh 0.20g of metoclopramide and add 3ml of pure water to dissolve it, add 0.10g of aspartame to the solution, stir and mix, pour into the compound film-making glue, then add 0.50ml of glycerin, stir, ultrasonic, and let it stand Defoaming. That is, the drug-containing mixed glue is obtained.

[0034] Sprinkle a small amount of release agent talcum powder on the board in advance, and evenly cover the whole board. Pour an appropriate amount of film slurry on the glass plate, adjust the hei...

Embodiment 3

[0036] Weigh 0.53g of PVA05-88, add 6ml of pure water, swell for 30min, heat in a water bath at 85°C to form a clear PVA solution; weigh 0.27g of CMC-Na, disperse it on the surface of 6ml of pure water, wait for it to sink and dissolve naturally, and let it stand overnight to obtain a viscous CMC-Na solution; mix the two solutions to obtain a composite film-making glue. Weigh 0.10g of ALG-Na dissolved in 5ml of pure water to obtain a viscous solution, and add it into the film-making glue. Weigh 0.20g of metoclopramide and add 3ml of pure water to dissolve, add 0.10g of aspartame to the solution, stir and mix, pour into the composite film-making glue, then add 1.00ml of glycerin, stir, ultrasonic, and let stand Defoaming. That is, the drug-containing mixed glue is obtained.

[0037] Sprinkle a small amount of release agent talcum powder on the board in advance, and evenly cover the whole board. Pour an appropriate amount of film slurry on the glass plate, adjust the height o...

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Abstract

The invention belongs to the field of medicinal preparations and in particular relates to a metoclopramide oral film and a preparation method thereof. Metoclopramide is a dopamine receptor blocking agent and has strong central anti-vomiting and gastrointestinal tract stimulation effects. The prepared film has good appearance, is fast to disintegrate, dispenses with water and chewing and has the effect of improving the medication safety and compliance of patients. The film is simple in production process and low in cost and is convenient to carry.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a metoclopramide oral film and a preparation method thereof. Background technique [0002] Antiemetic drugs in the category of digestive system drugs occupy a very important position in the field of adjuvant tumor therapy. With the increase in the incidence of tumors, the antiemetic drug market is also rising and expanding. In 2002, the global sales of antiemetic drugs exceeded US$1.5 billion. There are currently three main types of antiemetic drugs, each of which inhibits the emetic chemoreceptor area through different links to antiemetic, including thiazide drugs, antihistamines, and anticholinergic drugs. Metoclopramide, also known as metoclopramide and metoclopramide, is a dopamine receptor blocker commonly used in the treatment of nausea, vomiting, indigestion, belching and other gastrointestinal symptoms. Due to its cheap price and obvious antiemetic effect, it...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/38A61K31/166A61P1/14A61P1/08A61P1/16A61P1/18
CPCA61K9/006A61K9/7007A61K31/166A61K47/38
Inventor 周建平丁杨李昊天
Owner CHINA PHARM UNIV
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