Nano drug carrier having photothermal effect and preparation method and application thereof

A nano-drug carrier and photothermal effect technology, applied in the field of medicine, can solve the problems of low drug utilization, multi-drug resistance, and high toxicity of chemotherapy drugs, and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2017-02-22
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, drug chemotherapy is a common method in cancer treatment, but chemotherapy drugs are highly toxic, and systemic administration often leads to low drug utilization, serious side effects and multidrug resistance.

Method used

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  • Nano drug carrier having photothermal effect and preparation method and application thereof
  • Nano drug carrier having photothermal effect and preparation method and application thereof
  • Nano drug carrier having photothermal effect and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] This embodiment is a method for preparing a nano drug carrier with photothermal effect, including the following steps:

[0034] Step 1: Dissolve 2 g of 2-methylimidazole in 50 ml of deionized water and magnetically stir for 15 minutes to form a clear solution; then add 50 ml of 0.95 g of zinc nitrate hexahydrate aqueous solution dropwise to the above reaction solution, and continue the reaction for 30 minutes;

[0035] Step 2: Add 1 ml of 0.5 mg / ml graphene oxide aqueous solution to the reaction system in Step 1, and continue to stir and react for 1 hour to obtain a reaction product;

[0036] Step 3: Centrifuge the reaction product, wash it with water three times, and dry it in vacuum at 37° C. to obtain a metal organic framework / graphene oxide nano drug carrier.

[0037] Nano drug carrier particle shape analysis:

[0038] figure 1 A scanning electron microscope (SEM) picture of the nano drug carrier with photothermal effect prepared in Example 1.

[0039] Such as f...

Embodiment 2

[0041] This embodiment is a method for preparing a nano drug carrier with photothermal effect, including the following steps:

[0042] Step 1: Dissolve 2 g of 2-methylimidazole in 50 ml of deionized water and magnetically stir for 15 minutes to form a clear solution; then add 50 ml of 0.95 g of zinc nitrate hexahydrate aqueous solution dropwise to the above reaction solution, and continue the reaction for 30 minutes;

[0043] Step 2: Add 2 ml of 1 mg / ml graphene oxide aqueous solution to the reaction system in Step 1, and continue to stir and react for 1 hour to obtain a reaction product;

[0044] Step 3: Centrifuge the reaction product, wash it with water three times, and dry it in vacuum at 37° C. to obtain a metal organic framework / graphene oxide nano drug carrier.

[0045] Nano drug carrier particle shape analysis:

[0046] figure 2 The scanning electron microscope (SEM) picture of the nano drug carrier with photothermal effect prepared for Example 2.

[0047] Such as ...

Embodiment 3

[0049] This embodiment is a method for preparing a nano drug carrier with photothermal effect, including the following steps:

[0050] Step 1: Dissolve 2 g of 2-methylimidazole in 50 ml of deionized water and magnetically stir for 15 minutes to form a clear solution; then add 50 ml of 0.95 g of zinc nitrate hexahydrate aqueous solution dropwise to the above reaction solution, and continue the reaction for 30 minutes;

[0051] Step 2: Add 3 ml of 1.5 mg / ml graphene oxide aqueous solution to the reaction system in Step 1, and continue to stir and react for 1 hour to obtain a reaction product;

[0052] Step 3: Centrifuge the reaction product, wash it with water three times, and dry it in vacuum at 37° C. to obtain a metal organic framework / graphene oxide nano drug carrier.

[0053] Nano drug carrier particle shape analysis:

[0054] image 3 Scanning electron microscope (SEM) image of the nano-drug carrier with photothermal effect prepared for Example 3.

[0055] Such as ima...

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Abstract

The invention provides a nano drug carrier having a photothermal effect, wherein the nano drug carrier includes a metal organic framework and graphene oxide, wherein the metal organic framework is formed by self-assembly of an organic ligand and metal ions or metal clusters through coordination bonds, and the graphene oxide is embedded in the metal organic framework; the particle size of nano drug carrier particles is 30-500 nm. The invention also provides a preparation method of the nano drug carrier and an application of the nano drug carrier in loading of an anticancer drug. Because the nano drug carrier has the metal organic framework, the nano drug carrier provided by the invention can be used as a drug carrier; moreover, because the nano drug carrier has the graphene oxide embedded in the metal organic framework, the nano drug carrier can efficiently convert light and heat and is suitable for thermal therapy of cancer, and the thermal therapy also can improve the activity of a part of chemotherapy drugs to enhance the curative effect of the chemotherapy drugs; therefore, the nano drug carrier can allow thermal therapy on the cancer and drug therapy to be combined together, so as to improve the curative effect of the cancer.

Description

technical field [0001] The invention relates to a nano-medicine carrier with photothermal effect, a preparation method of the nano-medicine carrier and an application of the nano-medicine carrier, belonging to the technical field of medicine. Background technique [0002] Cancer treatment has always been a clinical problem and has become the leading cause of human death in addition to cardiovascular and cerebrovascular diseases. According to the World Health Organization (WHO) report, the incidence and mortality of cancer worldwide are on the rise. Tens of millions of people die from cancer every year, and about 60% of the new cancer cases in the world occur in developing countries. The current treatment methods for cancer include surgery, radiation therapy, chemical drug therapy, and biological therapy. Among them, drug chemotherapy is a common method in cancer treatment, but chemotherapy drugs are highly toxic, and systemic administration often leads to low drug utilizat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/69A61K31/704A61P35/00
CPCA61K41/0052A61K31/704
Inventor 朱钰方姚先先
Owner UNIV OF SHANGHAI FOR SCI & TECH
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