Preparation and application of nano metal-organic framework material PCN-223 based on porphyrin ligand

A PCN-223, nano metal technology, applied in the direction of iron group organic compounds without C-metal bonds, organic chemistry, iron organic compounds, etc., can solve the problems of poor drug loading and drug release, and achieve the effect of high release.

Inactive Publication Date: 2017-02-22
HARBIN UNIV OF SCI & TECH
View PDF2 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problem of poor drug-loading and drug-release properties of the existing carrier materials us

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation and application of nano metal-organic framework material PCN-223 based on porphyrin ligand
  • Preparation and application of nano metal-organic framework material PCN-223 based on porphyrin ligand
  • Preparation and application of nano metal-organic framework material PCN-223 based on porphyrin ligand

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0035] Embodiment 1: The preparation method of a porphyrin ligand-based nano metal organic framework material PCN-223 in this embodiment is completed according to the following steps:

[0036]1. Synthesis of 5,10,15,20-tetrakis(4-methoxycarbonylphenyl)porphyrin: add pyrrole and methyl para Benzoyl, and then heated to a temperature of 140-160°C under the condition of no light irradiation, and reflux reaction at a temperature of 140-160°C for 10h-14h, naturally cooled to room temperature after the reaction was completed, and the obtained suspension The liquid was suction filtered, and the solid matter was vacuum-dried to obtain a purple precipitate, namely 5,10,15,20-tetrakis(4-methoxycarbonylphenyl)porphyrin;

[0037] The volume of propionic acid described in step 1 and the amount of substance of pyrrole are 100mL: (0.04~0.05) mol;

[0038] The volume ratio of propionic acid described in step 1 and the amount of substance of methyl p-benzoyl are 100mL: (0.04~0.05) mol;

[003...

specific Embodiment approach 2

[0050] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the ratio of the volume of propionic acid to the substance of pyrrole in step 1 is 100 mL:0.043 mol. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0051] Specific embodiment three: this embodiment is different from specific embodiment one or two in that: the volume ratio of propionic acid described in step one to the substance ratio of methyl p-benzoyl is 100mL:0.042mol. Other steps and parameters are the same as those in Embodiment 1 or 2.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides preparation and application of nano metal-organic framework material PCN-223 based on porphyrin ligand. The invention relates to a preparation method and application of a metal-organic framework material. The invention aims at solving the problems that an existing carrier material used for loading a medicine 5-fluorouracil is poor in drug carrying performance and drug release performance. The preparation comprises the following steps of I, the synthesis of 5,10,15,20-tetra(4-methoxycarbonylphenyl)porphyrin; II, the synthesis of [5,10,15,20-tetra(4-methoxycarbonylphenyl)porphyrin] ferric chloride; III, the synthesis of organic ligand Fe(III)-TCPPCl; IV, the synthesis of the nano metal-organic framework material PCN-223. The maximum drug carrying amount of the nano metal-organic framework material PCN-223 prepared by the invention can reach 0.344g/g. The release performance of the medicine is also higher; the release rate can reach 90 percent. The convenience is provided for loading different medicines.

Description

technical field [0001] The invention relates to a preparation method and application of a metal organic framework material. Background technique [0002] The rapid development of metal-organic frameworks is a major breakthrough in the field of inorganic chemistry in the past two decades. MOFs materials are centered on metal centers or metal clusters. It is formed by self-assembly with organic ligands through coordination bonds, and has a highly periodic network crystalline complex, also known as a metal coordination polymer. [0003] The unique structural characteristics of the organic-inorganic hybrid of MOFs and its nanoscale pore size enable it to provide one or more catalytic sites in a cavity, which cannot be achieved by other materials. Therefore, MOFs materials have many attractive features: first, MOFs materials have a variety of components, and a wide variety of MOFs materials can be synthesized by selecting different metal ions and different ligands. Second, the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07F19/00A61K31/513A61K47/24
CPCC07F15/025A61K31/513A61K47/24
Inventor 张凤鸣董鸿孙晓君喻琪杨萍杨豆豆张欣王雪亮
Owner HARBIN UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap