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Preparation and application of nano metal-organic framework material PCN-223 based on porphyrin ligand

A PCN-223, nano metal technology, applied in the direction of iron group organic compounds without C-metal bonds, organic chemistry, iron organic compounds, etc., can solve the problems of poor drug loading and drug release, and achieve the effect of high release.

Inactive Publication Date: 2017-02-22
HARBIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of the present invention is to solve the problem of poor drug-loading and drug-release properties of the existing carrier materials used to load the drug 5-fluorouracil, and to provide a preparation and application of a porphyrin ligand-based nano metal organic framework material PCN-223

Method used

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  • Preparation and application of nano metal-organic framework material PCN-223 based on porphyrin ligand
  • Preparation and application of nano metal-organic framework material PCN-223 based on porphyrin ligand
  • Preparation and application of nano metal-organic framework material PCN-223 based on porphyrin ligand

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specific Embodiment approach 1

[0035] Embodiment 1: The preparation method of a porphyrin ligand-based nano metal organic framework material PCN-223 in this embodiment is completed according to the following steps:

[0036]1. Synthesis of 5,10,15,20-tetrakis(4-methoxycarbonylphenyl)porphyrin: add pyrrole and methyl para Benzoyl, and then heated to a temperature of 140-160°C under the condition of no light irradiation, and reflux reaction at a temperature of 140-160°C for 10h-14h, naturally cooled to room temperature after the reaction was completed, and the obtained suspension The liquid was suction filtered, and the solid matter was vacuum-dried to obtain a purple precipitate, namely 5,10,15,20-tetrakis(4-methoxycarbonylphenyl)porphyrin;

[0037] The volume of propionic acid described in step 1 and the amount of substance of pyrrole are 100mL: (0.04~0.05) mol;

[0038] The volume ratio of propionic acid described in step 1 and the amount of substance of methyl p-benzoyl are 100mL: (0.04~0.05) mol;

[003...

specific Embodiment approach 2

[0050] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the ratio of the volume of propionic acid to the substance of pyrrole in step 1 is 100 mL:0.043 mol. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0051] Specific embodiment three: this embodiment is different from specific embodiment one or two in that: the volume ratio of propionic acid described in step one to the substance ratio of methyl p-benzoyl is 100mL:0.042mol. Other steps and parameters are the same as those in Embodiment 1 or 2.

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Abstract

The invention provides preparation and application of nano metal-organic framework material PCN-223 based on porphyrin ligand. The invention relates to a preparation method and application of a metal-organic framework material. The invention aims at solving the problems that an existing carrier material used for loading a medicine 5-fluorouracil is poor in drug carrying performance and drug release performance. The preparation comprises the following steps of I, the synthesis of 5,10,15,20-tetra(4-methoxycarbonylphenyl)porphyrin; II, the synthesis of [5,10,15,20-tetra(4-methoxycarbonylphenyl)porphyrin] ferric chloride; III, the synthesis of organic ligand Fe(III)-TCPPCl; IV, the synthesis of the nano metal-organic framework material PCN-223. The maximum drug carrying amount of the nano metal-organic framework material PCN-223 prepared by the invention can reach 0.344g / g. The release performance of the medicine is also higher; the release rate can reach 90 percent. The convenience is provided for loading different medicines.

Description

technical field [0001] The invention relates to a preparation method and application of a metal organic framework material. Background technique [0002] The rapid development of metal-organic frameworks is a major breakthrough in the field of inorganic chemistry in the past two decades. MOFs materials are centered on metal centers or metal clusters. It is formed by self-assembly with organic ligands through coordination bonds, and has a highly periodic network crystalline complex, also known as a metal coordination polymer. [0003] The unique structural characteristics of the organic-inorganic hybrid of MOFs and its nanoscale pore size enable it to provide one or more catalytic sites in a cavity, which cannot be achieved by other materials. Therefore, MOFs materials have many attractive features: first, MOFs materials have a variety of components, and a wide variety of MOFs materials can be synthesized by selecting different metal ions and different ligands. Second, the...

Claims

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Application Information

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IPC IPC(8): C07F19/00A61K31/513A61K47/24
CPCC07F15/025A61K31/513A61K47/24
Inventor 张凤鸣董鸿孙晓君喻琪杨萍杨豆豆张欣王雪亮
Owner HARBIN UNIV OF SCI & TECH
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