Thermal response shape memory hydrogel based on hydrogen-bond interaction and preparation method of thermal response shape memory hydrogel

A technology of hydrogen bonding and hydrogel, applied in the field of heat-responsive shape memory hydrogel and its preparation, can solve the problems of limited application and weak mechanical properties, and achieve low raw material cost, good shape memory performance, and mild reaction conditions Effect

Active Publication Date: 2017-02-22
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the weak mechanical properties of hydrogels greatly limit their applications.

Method used

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  • Thermal response shape memory hydrogel based on hydrogen-bond interaction and preparation method of thermal response shape memory hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A heat-responsive shape memory hydrogel based on hydrogen bonding, which includes the following weights of raw materials: N,N'-dimethylacrylamide (DMA) 1.7g, N,N'-methylenebisacrylamide ( MBA) 0.05g, 2-urea-4[1H]-methylpyrimidone methacrylate (UPyMA) 1.6g, ammonium persulfate 0.03g, dimethylsulfoxide (DMASO) 10mL.

[0018] Above-mentioned each raw material is prepared according to the following steps:

[0019] 1) N,N'-dimethylacrylamide (DMA), N,N'-methylenebisacrylamide (MBA), 2-urea-4[1H]-methylpyrimidinone methacrylate ( UPyMA), ammonium persulfate, and dimethyl sulfoxide (DMASO) are put into the container in proportion, preheated at 40-50°C to dissolve and mix the raw materials evenly, then heat up to 65-80°C, and react for 3 hours;

[0020] 2) Soak the prepared DMSO gel in deionized water for a certain period of time at room temperature, so that the DMSO is completely replaced by water;

[0021] 3) Continue to swell the hydrogel obtained in step 2 in deionized wa...

Embodiment 2

[0025] The shape-memory hydrogel of this embodiment includes the following raw materials by weight: 2.1 g of N,N'-dimethylacrylamide (DMA), 0.06 g of N,N'-methylenebisacrylamide (MBA), 2 - 1.3 g of urea-4[1H]-methylpyrimidinone methacrylate (UPyMA), 0.05 g of ammonium persulfate, and 10 mL of dimethyl sulfoxide (DMASO).

[0026] The preparation method of the hydrogen bond-based shape memory hydrogel in this example is the same as that in Example 1.

[0027] The hydrogen bond-based shape memory hydrogel of this example has substantially the same mechanical properties and shape memory properties as those of Example 1.

Embodiment 3

[0029] The shape-memory hydrogel of this embodiment includes the following raw materials by weight: 2.8 g of N,N'-dimethylacrylamide (DMA), 0.06 g of N,N'-methylenebisacrylamide (MBA), 2 - 1.2 g of urea-4[1H]-methylpyrimidinone methacrylate (UPyMA), 0.04 g of ammonium persulfate, and 10 mL of dimethyl sulfoxide (DMSO).

[0030] The preparation method of the hydrogen bond-based shape memory hydrogel of this embodiment is the same as that of the first embodiment.

[0031] The shape-memory hydrogel based on hydrogen bonds in this example has substantially the same mechanical properties and shape-memory properties as those in Example 1.

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Abstract

The invention discloses thermal response shape memory hydrogel based on hydrogen-bond interaction and a preparation method of the thermal response shape memory hydrogel. The hydrogel is a copolymer of N,N'-dimethyl acrylamide (DMA), N,N'-methylene bisacrylamide (MBA) and 2-urea-4[1H]-UPyMA. According to the shape memory hydrogel, dynamic hydrogen bonds formed between UPy(2-urea-4-[1H]-methyl pyrimidone) units on polymer side chains are utilized, and the strength of covalent bonds and the reversibility of physical crosslinking are achieved. The raw materials are easy to obtain, and the preparation process is simple. The prepared hydrogel based on quadruple hydrogen bonds has high mechanical performance and good shape memory performance and has wide application prospects on the aspects of medicine conveying and the like.

Description

technical field [0001] The invention relates to a heat-responsive shape-memory hydrogel based on hydrogen bonding and a preparation method thereof, belonging to the field of functional polymer materials. Background technique [0002] A hydrogel is a substance that swells in water but does not dissolve. Over the past few decades, hydrogels have been widely used in biomedicine, such as medical devices such as drug carriers, wound dressings, cartilage replacements, and artificial kidney membranes. However, the weak mechanical properties of hydrogels greatly limit their applications. As a medical material, in addition to certain biocompatibility and non-toxicity, it must also have certain mechanical strength and deformation recovery performance. Traditional hydrogels mainly rely on chemical crosslinking, but in the research of new hydrogels, the combination of chemical crosslinking and physical crosslinking has attracted more and more attention. [0003] When used as an impla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/54C08F222/38C08F220/36C08J3/075C08L33/24C08L33/14C08L35/00
CPCC08F220/36C08F220/54C08F222/385C08J3/075C08J2333/14C08J2333/24C08J2335/00
Inventor 张洪吉陈然陈益鸣陈明清
Owner JIANGNAN UNIV
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