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Medical radiation protective emulsifiable paste and preparing method thereof

A technology for radiation protection and cream, which is applied in the field of medical radiation protection cream and its preparation, can solve the problems of poor stability of pharmaceutical preparations, complicated process, high raw material and production costs, etc., to speed up skin microcirculation, Accelerates healing and relieves skin tension

Inactive Publication Date: 2017-03-08
康多宝医疗健康产品(湖南)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Domestic research on medical radiation protection is mainly based on the mechanism of radiation damage to tissues and cells. It contains free radical scavenger superoxide dismutase (SOD), which can quickly and effectively penetrate the skin and wounds, and clear the skin. A large number of free radicals produced on the surface, pharmaceutical preparations to prevent and reduce radiation skin damage, such as patents: ZL 200510116829.9, CN 101069741A, CN 103751770 A; however, the stability of the pharmaceutical preparation made of superoxide dismutase (SOD) is not good, and the process The process is complicated, the cost of raw materials and production is high, and it is necessary to mix agent A and agent B before use

Method used

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  • Medical radiation protective emulsifiable paste and preparing method thereof
  • Medical radiation protective emulsifiable paste and preparing method thereof
  • Medical radiation protective emulsifiable paste and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A kind of medical radiation protection cream and preparation method thereof, it is characterized in that the component content of described cream is:

[0024]

[0025] Process steps:

[0026] (1) Take stearic acid, lanolin, and sesame oil and heat them to above 75°C to dissolve them, stir well to obtain solution A.

[0027] (2) Take polyethylene glycol 400, 200:1 decolorized aloe vera gel freeze-dried powder, triethanolamine, ethylparaben, water and heat to above 75°C to dissolve, stir well to obtain solution B.

[0028] (3) Add solution B to solution A, stir at about 75°C for 20 minutes, and cool to obtain the product.

[0029] System stability: the system is a single stable cream, placed for 3 months at a temperature of 37°C±2°C and a relative humidity of 75%±5%, and there is no significant change in the quality indicators of the test product; , centrifuged for 20 minutes, no stratification.

[0030] Biological Evaluation:

[0031] A cytotoxicity test was carri...

Embodiment 2

[0036] A kind of medical radiation protection cream and preparation method thereof, it is characterized in that the component content of described cream is:

[0037]

[0038] Process steps:

[0039] (1) Take stearic acid, lanolin, and sesame oil and heat them to above 75°C to dissolve them, stir well to obtain solution A.

[0040] (2) Take polyethylene glycol 400, 200:1 decolorized aloe vera gel freeze-dried powder, triethanolamine, methylparaben, propylparaben, water and heat to above 75°C to dissolve, stir well to obtain solution B .

[0041] (3) Add solution B to solution A, stir at about 75°C for 20 minutes, and cool to obtain the product.

[0042] System stability: the system is a single stable cream, placed for 3 months at a temperature of 37°C±2°C and a relative humidity of 75%±5%, and there is no significant change in the quality indicators of the test product; , centrifuged for 20 minutes, no stratification.

[0043] Biological Evaluation:

[0044] Adopt MTT m...

Embodiment 3

[0049] A kind of medical radiation protection cream and preparation method thereof, it is characterized in that the component content of described cream is:

[0050]

[0051] Process steps:

[0052] (1) Take stearic acid, lanolin, and sesame oil and heat them to above 75°C to dissolve them, stir well to obtain solution A.

[0053] (2) Take polyethylene glycol 400, decolorized aloe vera gel juice, triethanolamine, methylparaben, propylparaben, and water and heat to above 75°C to dissolve, stir well, and obtain solution B.

[0054] (3) Add solution B to solution A, stir at about 75°C for 20 minutes, and cool to obtain the product.

[0055] System stability: The system is a single and stable cream, which has no obvious change in the quality indicators of the test product after being placed for 3 months under the conditions of temperature 37°C±2°C and relative humidity 75%±5%.

[0056] Biological Evaluation:

[0057] The cytotoxicity test was carried out on the cream of Exam...

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PUM

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Abstract

The invention relates to medical radiation protective emulsifiable paste and a preparing method thereof. The effective ingredients of the medical radiation protective emulsifiable paste comprise stearic acid, wool fat, polyethylene glycol 400, aloe extracts, sesame oil, triethanolamine, preservative and water. The medical radiation protective emulsifiable paste is mainly used for preventing inflammatory damages caused by irradiation on skin and mucous membrane of various kinds of ionization radiation such as beta ray, gamma ray and x-ray and radioactive isotope; meanwhile, the medical radiation protective emulsifiable paste is beneficial to remission and treatment of acute radiodermatitis and extremely dry skin conditions, capable of maintaining moisture of skin of field of radiotherapy, isolating intervention of adverse factors in the environment, accelerating skin microcirculation speed, and reliving tautness of the skin and accelerating wound healing speed, and does not have intervention on radiotherapy of cancer patients at the same time.

Description

technical field [0001] The present invention relates to the field of pharmaceutical preparations, in particular to a formula for medical radiation protection cream, which is mainly used for the protection of various ionizing radiations including β, γ, X-rays and radioactive isotopes irradiating the skin and mucous membranes from inflammatory damage. , it is beneficial to alleviate and treat acute radiation dermatitis and very dry skin conditions, keep the skin moist in the radiation field, isolate the intervention of unfavorable environmental factors, accelerate the skin microcirculation speed, relieve skin tightness, and speed up wound healing. Interference with radiotherapy for cancer patients. Background technique [0002] Radiation dermatitis (adiodermatitis) is the inflammatory damage caused by various ionizing radiations including β, γ, X-rays and radioactive isotopes irradiating the skin and mucous membranes. With the improvement of radiation awareness and protection...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/886A61K8/9794A61K8/92A61K9/06A61P17/00A61P17/16A61Q17/00A61Q17/04
Inventor 肖本友李健和张献冲吴静红刘耀陈炳艳
Owner 康多宝医疗健康产品(湖南)有限公司
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