Application of patchoulicalcohol to preparing medicines for preventing and treating ulcerative colitis

A technology for ulcerative colitis and patchouli alcohol, which is applied in the field of drugs containing hydroxyl compounds, can solve the problems of undisclosed biological activity of patchouli alcohol for ulcerative colitis, and achieve good promotion and application prospects

Active Publication Date: 2017-03-22
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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  • Application of patchoulicalcohol to preparing medicines for preventing and treating ulcerative colitis
  • Application of patchoulicalcohol to preparing medicines for preventing and treating ulcerative colitis
  • Application of patchoulicalcohol to preparing medicines for preventing and treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0108] Example 1 (tablet)

[0109] Take 400g of patchouli alcohol, add 480g of lactose, 754g of starch and mix evenly, use 7% starch slurry 350g as a binder, wet granulate, dry, add 16g of magnesium stearate, mix evenly, and press into each tablet containing patchouli There are 10,000 tablets of 40mg fragrant alcohol, each with a net weight of 0.2g. Orally, for the treatment of ulcerative colitis. Symptoms: Abdominal pain, persistent diarrhea and bloody stools, fever, abdominal distension, etc.

example 2

[0110] Example 2 (capsules)

[0111] Take 400g of patchouli alcohol, add 980g of lactose, 1254g of starch and mix evenly, use 7% starch slurry 350g as binder, wet granulate, dry, add 16g of magnesium stearate, mix evenly, fill to No. 1 capsule 10,000 capsules, each capsule contains 40mg of patchouli alcohol, and the net weight of each capsule is 0.3g. Orally, for the treatment of ulcerative colitis. Symptoms: Abdominal pain, persistent diarrhea and bloody stools, fever, abdominal distension, etc.

example 3

[0112] Example 3 (dropping pills)

[0113] Get patchouli alcohol 300g, add appropriate amount of PEG4000 as substrate, appropriate amount of liquid paraffin as coolant; dripping method is made into drop pills containing 6 mg of patchouli alcohol per pill, net weight of each pill is 30 mg. Orally, for the treatment of ulcerative colitis. Symptoms: Abdominal pain, persistent diarrhea and bloody stools, fever, abdominal distension, etc.

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Abstract

The invention relates to application of patchoulicalcohol to preparing medicines for preventing and treating ulcerative colitis. The medicines comprise the patchoulicalcohol and medically acceptable excipients. The application has the advantages that the vitality of myeloperoxidase (MPO) which reflects the degrees of colitis diseases can be reduced by the patchoulicalcohol in the medicines, expression of tight junction proteins (TJs) and mucoproteins can be promoted, effects of protecting intestinal epithelium mucous membrane barriers can be realized, and obvious effects of preventing and treating the ulcerative colitis can be realized.

Description

technical field [0001] The present invention relates to pharmaceutical preparations containing organic active ingredients, in particular to medicines containing hydroxyl compounds, which can be used for treating ulcerative colitis. Background technique [0002] Ulcerative colitis (UC) is a chronic inflammation of the colon with unknown etiology and pathogenesis. The course of the disease is lengthy and the range of lesions is extensive. The lesions are mainly located in the mucosal layer of the colon, mainly ulcers, mostly involving the rectum and sigmoid colon, and sometimes throughout the entire colon. Ulcerative colitis has the characteristics of high acute fulminant mortality rate, high chronic persistent cancer rate, and easy recurrence. The clinical manifestations are: abdominal pain, persistent diarrhea and bloody stool, fever, abdominal distension and other symptoms, which seriously affect people's quality of life , and there is no specific drug at present, so it is...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P1/04
CPCA61K31/045
Inventor 张晓君苏子仁赖小平曾惠芳屈畅余秀婷杨光华
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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