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Preparation method and application of water-soluble carboxymethyl chitosan with controllable molecular weight

A carboxymethyl chitosan, water-soluble technology, applied in the field of water-soluble carboxymethyl chitosan, can solve the problem of not being able to control the molecular weight range, etc., and achieve good moisture absorption effect

Inactive Publication Date: 2017-03-22
北京甲壳生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no range that can control the molecular weight, and the influence of molecular weight changes on the moisture retention, water absorption and antibacterial properties of carboxymethyl chitosan is studied

Method used

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  • Preparation method and application of water-soluble carboxymethyl chitosan with controllable molecular weight
  • Preparation method and application of water-soluble carboxymethyl chitosan with controllable molecular weight
  • Preparation method and application of water-soluble carboxymethyl chitosan with controllable molecular weight

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preparation example Construction

[0018] A preparation method of water-soluble carboxymethyl chitosan with controllable molecular weight, comprising the steps of:

[0019] S1 Grind chitin, dissolve it in 10 times the volume of 40% NaOH solution, put it in a microwave reactor, and heat it at 30 degrees for 20 minutes at a power of 400w. After the reaction, adjust it to neutral with hydrochloric acid, and add 5 times volume of ethanol, a white solid is separated out, and dried to obtain chitosan;

[0020] S2 dissolves above-mentioned chitosan in 30% NaOH solution, adds the chloroacetic acid of chitosan equal quality, this chloroacetic acid is dissolved in the isopropanol of 5 times of mass, stirs evenly, puts in microwave reactor, in Under the power of 600w, react at 25 degrees for 60 minutes, adjust to neutral with hydrochloric acid at the end of the reaction, precipitate white powder solid at low temperature, and dry to obtain carboxymethyl chitosan;

[0021] S3 Dissolve the above-mentioned carboxymethyl chit...

Embodiment 1

[0023] A preparation method of water-soluble carboxymethyl chitosan with controllable molecular weight, comprising the steps of:

[0024] S1 Grind 100g of chitin, dissolve it in 1L of 40% NaOH solution, put it in a microwave reactor, and heat it at 30 degrees for 20 minutes at a power of 400w. After the reaction is completed, adjust it to neutral with 1mol / L hydrochloric acid. The ethanol of 5 times of volume, separates out white solid, oven dry obtains chitosan;

[0025] S2 dissolves above-mentioned chitosan in 30% NaOH solution, adds the chloroacetic acid of chitosan equal quality, this chloroacetic acid is dissolved in the isopropanol of 5 times of mass, stirs evenly, puts in microwave reactor, in Under the power of 600w, react at 25 degrees for 60 minutes, adjust to neutral with 1mol / L hydrochloric acid at the end of the reaction, precipitate white powder solid at low temperature, and dry to obtain carboxymethyl chitosan;

[0026] S3 dissolves the above-mentioned carboxym...

Embodiment 2

[0030] A preparation method of water-soluble carboxymethyl chitosan with controllable molecular weight, comprising the steps of:

[0031] S1 Grind 100g of chitin, dissolve it in 1L of 40% NaOH solution, put it in a microwave reactor, and heat it at 30 degrees for 20 minutes at a power of 400w. After the reaction is completed, adjust it to neutral with 1mol / L hydrochloric acid. The ethanol of 5 times of volume, separates out white solid, oven dry obtains chitosan;

[0032] S2 dissolves above-mentioned chitosan in 30% NaOH solution, adds the chloroacetic acid of chitosan equal quality, this chloroacetic acid is dissolved in the isopropanol of 5 times of mass, stirs evenly, puts in microwave reactor, in Under the power of 600w, react at 25 degrees for 60 minutes, adjust to neutral with 1mol / L hydrochloric acid at the end of the reaction, precipitate white powder solid at low temperature, and dry to obtain carboxymethyl chitosan;

[0033] S3 dissolves the above-mentioned carboxym...

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Abstract

The invention relates to a preparation method of water-soluble carboxymethyl chitosan with controllable molecular weight. The preparation method includes the steps that S1, chitin is ground, dissolved in an NaOH solution and put into a microwave reactor, the mixture is adjusted to be neutral with hydrochloric acid after reaction is ended, solids are separated out, and chitosan is obtained through drying; S2, the chitosan is dissolved in the NaOH solution, chloroacetic acid is added and dissolved in isopropyl alcohol, the mixture is stirred uniformly, put into the microwave reactor and adjusted to be neutral with hydrochloric acid after reaction is ended, solids are separated out, and carboxymethyl chitosan is obtained through drying; S3, the carboxymethyl chitosan is dissolved in a hydrogen peroxide solution, the mixture is put into the microwave reactor, ultrafiltration is carried out after reaction is ended, carboxymethyl chitosan is obtained, solids are separated out, and the water-soluble carboxymethyl chitosan is obtained through drying. The invention further discloses application of the water-soluble carboxymethyl chitosan with the controllable molecular weight. The carboxymethyl chitosan prepared through the method can achieve the controllable molecular weight, and has the good effects of moisture absorbing and keeping and restraining bacteria.

Description

technical field [0001] The invention relates to a water-soluble chitosan, especially a water-soluble carboxymethyl chitosan with controllable molecular weight, which has good moisture retention, water absorption and antibacterial properties and can be used as a cosmetic raw material. Background technique [0002] 1. Chitin, (C8H13O5N)n, also known as chitin, its English name is Chitin. It was discovered by French scholar Braconno in 1811 and extracted from crustacean shells by Ogier in 1823. Light beige to white, soluble in concentrated hydrochloric acid / phosphoric acid / sulfuric acid / acetic acid, insoluble in alkali and other organic solvents, and insoluble in water. Deacetylated derivatives of chitin (Chitosan derivatives) Chitosan (chitosan) is insoluble in water, soluble in some dilute acids. It is a linear polymer polysaccharide, that is, a natural neutral mucopolysaccharide. If the acetyl group is removed by concentrated alkali treatment, chitosan can be obtained. It...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08A61K8/73
CPCC08B37/003A61K8/736
Inventor 吴鹏张勇刘文杰李翠变史欣霞吴雨蓓
Owner 北京甲壳生物科技有限公司