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Extracting process of licorice flavonoid compound

A technology of licorice flavonoids and extraction process, which is applied in the chemical field, can solve the problems of high temperature resistance, high cost, and low extraction rate, and achieve the effect of reducing irritation and cost

Inactive Publication Date: 2017-05-10
新疆全泰兴药业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The main active ingredient of licorice flavonoids powder is licorice flavonoids, because it contains a variety of organic components, more acidic components, and many components are not resistant to high temperature, so the extraction rate of licorice flavonoids has generally been low for a long time , high cost issues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1. Ethanol extraction and concentration

[0023] Add the remaining licorice residue after extracting the licorice extract into the extraction tank, heat and extract twice with 85% ethanol, each time for 1 hour, and the amount of 85% ethanol used for each 400kg licorice residue extraction twice is 3m 3 and 1.8m 3 , and then the extracts were combined and concentrated to a thick paste.

[0024] Licorice flavonoids are highly polar and belong to organic matter. We use organic solvent ethanol for extraction. It has been verified that after two ethanol extractions, the extracts in licorice residue are basically completely extracted.

[0025] 2. Alkali-soluble acid precipitation

[0026] Under normal temperature environment, dissolve the thick paste with a sodium carbonate solution with a concentration of 5wt%, precipitate for more than 24 hours, take the supernatant, adjust the pH value of the supernatant to 4 with 15v / v% hydrochloric acid, and filter to obtain the precipi...

Embodiment 2

[0037] 1. Ethanol extraction and concentration

[0038] Add the remaining licorice residue after extracting the licorice extract into the extraction tank, heat and extract twice with 85% ethanol, each time for 1 hour, and the amount of 85% ethanol used for each 400kg licorice residue extraction twice is 3m 3 and 1.8m 3 , and then the extracts were combined and concentrated to a thick paste.

[0039] 2. Alkali-soluble acid precipitation

[0040] Under normal temperature environment, dissolve the thick paste with a sodium carbonate solution with a concentration of 5wt%, and precipitate for more than 24 hours, take the supernatant, adjust the pH value of the supernatant to 5 with 15v / v% hydrochloric acid, and filter to obtain the precipitate , and the precipitate was washed with water to pH 7.

[0041] 3. Drying and granulation

[0042] Place the precipitate after washing with water in a tray, place the tray in a vacuum drying oven, dry in vacuum at below 60°C for 5 hours, an...

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PUM

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Abstract

The invention discloses an extracting process of a licorice flavonoid compound. The extracting process is characterized in that licorice root residues remaining after extraction of liquorice cream are used as raw materials, and the extracting process comprises steps of extracting and concentrating, alkali extraction and acid precipitation, drying and granulation, and hot-air drying. The extracting process comprises the following specific steps: (1) extracting the licorice root residues remaining after extraction of liquorice cream twice by using 85% ethanol, merging extraction solutions and concentrating the extraction solutions into thick paste; (2) dissolving the thick paste with a sodium carbonate solution, precipitating for above 24 hours, taking supernate, adjusting pH value to be 4-5, filtering to obtain precipitate, and washing the precipitate with water until pH is 6-7; (3) drying the precipitate under vacuum at first and then granulating; and (4) drying wet particles in a hot-air circulating oven. The extracting process of the licorice flavonoid compound has the beneficial effects that (1) the extraction rate of the licorice root residues is above 2% and is greatly increased, and the content of the licorice flavonoid compound in the particles is above 85%, and is far higher than the national requirement in which the content of the licorice flavonoid compound requires to be above 50%; (2) irritation of the drug to patients is reduced; and (3) the cost is reduced.

Description

technical field [0001] The invention relates to an extraction process, in particular to an extraction process of licorice flavonoids, and belongs to the field of chemical technology. Background technique [0002] The original powder of licorice flavonoids has strong adsorption, low solubility in water, insoluble in medium and weak acids, partially soluble in strong acids, and easily soluble in ethanol and alkali. [0003] The main active ingredient of licorice flavonoids powder is licorice flavonoids, because it contains a variety of organic components, more acidic components, and many components are not resistant to high temperature, so the extraction rate of licorice flavonoids has generally been low for a long time , high cost issues. Contents of the invention [0004] In order to solve the deficiencies in the prior art, the object of the present invention is to provide a process for extracting licorice flavonoids with high extraction rate and low cost. [0005] In or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484
CPCA61K36/484A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 冀祖恩周寒利赵向英
Owner 新疆全泰兴药业科技有限公司