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Method for preparing dicalicium phosphate anhydrous (DCPA) bioceramic coating on surface of pure titanium

An anhydrous calcium hydrogen phosphate and bioceramic technology, applied in the field of surgical implants, can solve the problems of incomplete coverage of the matrix, high safety performance requirements, high current or high temperature, etc., and achieve the promotion of stem cell osteogenic differentiation and safety requirements. Low, pure effect

Inactive Publication Date: 2017-05-10
JIANGSU UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In summary, the currently known DCPA coating preparation methods mainly have the following disadvantages: (1) complex equipment and high safety performance requirements; (2) high current or high temperature (over 100°C) is required
Operation; (3) The prepared DCPA coating cannot completely cover the substrate or there are impurity phases; (4) The working environment is poor, the efficiency is low, and the energy consumption is large

Method used

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  • Method for preparing dicalicium phosphate anhydrous (DCPA) bioceramic coating on surface of pure titanium
  • Method for preparing dicalicium phosphate anhydrous (DCPA) bioceramic coating on surface of pure titanium
  • Method for preparing dicalicium phosphate anhydrous (DCPA) bioceramic coating on surface of pure titanium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Weigh 5 g of analytically pure DCPA powder with an electronic balance, transfer it to a glass beaker, add 96 mL of deionized water, add 4 moL of dilute hydrochloric acid HCl with a concentration of 0.04 mol / L, stir with a glass rod, and wait until CaHPO 4 After complete dissolution, transfer the solution to a PET tie-top spray bottle. Sandpaper-polished and ultrasonically cleaned pure titanium was treated in a mixed solution of hydrochloric acid-sulfuric acid at 70°C for 30 minutes, and then rinsed with a large amount of deionized water to obtain a super-hydrophilic acid-etched surface. Put the pure titanium substrate into a constant temperature resistance box, set the temperature at 50°C, and keep it warm for 5 minutes, and confirm that the surface of the substrate is completely dry. Press the spray pump so that the DCPA solution is evenly sprayed on the titanium substrate. Since the substrate is super-hydrophilic, the DCPA solution can spread evenly on its surface. A...

Embodiment 2

[0024] The steps are basically the same as in Example 1, except that the ratio of the spraying solution this time is: 25g of analytically pure DCPA, 80ml of deionized water, and 20mL of dilute hydrochloric acid HCl with a concentration of 0.20mol / L. The number of times of spray drying is 30 times, and the drying temperature is 60°C. SEM( Figure 4 ), XRD ( Figure 5 ) analysis results show that the DCPA coating prepared by this method is uniform and complete, and can completely cover the titanium substrate.

Embodiment 3

[0026] The steps are basically the same as in Example 1, except that the ratio of the spraying solution this time is: 10g of analytically pure DCPA, 92ml of deionized water, and 8mL of dilute hydrochloric acid HCl with a concentration of 0.08mol / L. The number of times of spray drying is 60 times, and the drying temperature is 70°C. SEM( Figure 6 ), XRD ( Figure 7 ) analysis results show that the DCPA coating prepared by this method is uniform, complete and dense, and can completely cover the titanium substrate.

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Abstract

The invention discloses a method for preparing a dicalicium phosphate anhydrous (DCPA) bioceramic coating on the surface of pure titanium. The method comprises the following steps: preparing an aqueous solution of the DCPA, wherein the concentration of the aqueous solution is 0.05 to 0.25g / ml; carrying out hydrophilic pretreatment on a pure titanium substrate; heating the substrate under the condition of 50 to 100DEG C, and enabling the surface of the substrate to be dry; repeatedly and uniformly spraying the aqueous solution of the DCPA on the surface of the substrate. According to the method disclosed by the invention, liquid drops are refined by using a dissolution-separation principle and adopting a spraying method, and CaHPO4.2H2O is dehydrated at lower temperature to form the DCPA; the method is simple in preparation process, mild in reaction conditions and not high in safety requirement; meanwhile, according to a bioactive DCPA coating prepared on the surface of a metal matrix by adopting the method disclosed by the invention, the proportions of Ca / P elements are not changed; the coating is pure in phase, uniform and compact, and can completely cover a matrix; interaction between an implant and tissue cells can be adjusted, osteoblastic differentiation of stem cells is promoted, and the combinability of the implant and bone is improved.

Description

technical field [0001] The invention relates to a method for preparing anhydrous calcium hydrogen phosphate bioceramic coating on the surface of pure titanium, which belongs to the technical field of surgical implants. Background technique [0002] Pure titanium is the main metal material for the manufacture of load-bearing bone implants, and its tight combination with the host bone is the prerequisite for its long-term and stable repairing effect. However, medical pure titanium is a biologically inert material, and the products directly manufactured by it are prone to problems such as loosening, abrasion, fibrous tissue involvement and infection after being implanted in the human body. the most feasible way to operate. Hydroxyapatite (HAP) coating has become the most widely used coating on the surface of intraosseous metal implants due to its good osteoconductivity, but HAP is not osteoinductive. With the growing desire of patients for early loading and fast healing of im...

Claims

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Application Information

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IPC IPC(8): A61L27/32A61L27/06A61L27/54C04B35/447C04B35/622
CPCA61L27/32A61L27/06A61L27/54A61L2300/606A61L2430/02C04B35/447C04B35/62222C04B2235/3212
Inventor 史兴岭徐玲利吴铭方赵超张广志刘佳倪宗泽
Owner JIANGSU UNIV OF SCI & TECH
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