Endoscopic hemostatic clips with thrombin sustained release function and method for preparing endoscopic hemostatic clips
A technology of thrombin and hemostatic clips, applied in coating, medical science, surgery, etc., to increase the concentration of surrounding tissue
Inactive Publication Date: 2017-05-10
泰安市御翔医疗科技有限公司
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Problems solved by technology
[0003] The purpose of the present invention is to solve some problems existing in the field of the existing thrombin slow-release medical devices, and provide a thrombin slow-release endoscopic hemostatic clip
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specific Embodiment 1
[0034] 1. The SU304 austenitic stainless steel metal base 12 is ultrasonically washed with deionized water for 5 minutes to remove oil stains or rust on the metal surface 13 . After the surface is clean, it is placed in a drying oven at 60° C. for 8 minutes, and no water droplets remain on the surface as qualified; the thickness of the stainless steel metal base 12 is 0.5 mm.
[0035] 2. 40 parts of 5 mol / l hydroxyethylidene diphosphonic acid solution, 5 parts of 3 mol / l orthophosphoric acid solution, and 1 part of hydrogen peroxide are used to prepare a mixed solution; 1 part of the solution is 1 liter, and 1 part of hydrogen peroxide is 1 g. The stainless steel metal base 12 was immersed in the above mixed solution at 25° C. for 2 minutes to prepare the phosphate layer 15 and the chemical conversion film layer 14 on the metal surface 13 .
[0036] 3. After taking out, after the excess solution flows down, it is placed in a drying box at 60° C. to dry for 8 minutes, so that t...
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Abstract
The invention provides a method for preparing endoscopic hemostatic clips with a thrombin sustained release function. The method includes steps of (1), carrying out ultrasonic washing and drying on metal matrixes by the aid of deionized water, then soaking the metal matrixes in mixed solution, taking the metal matrixes out of the mixed solution, secondarily drying the metal matrixes and then washing the metal matrixes; (2), soaking the metal matrixes treated at the step (1) in hydroxyapatite suspension, taking the metal matrixes out of the hydroxyapatite suspension and drying the metal matrixes; (3), soaking the metal matrixes treated at the step (2) in thrombin solution and taking the metal matrixes out of the thrombin solution to obtain the endoscopic hemostatic clips which are the metal matrixes. The method has the advantages that medicines to which the thrombin only can be locally applied can be subjected to targeted sustained release, and accordingly targeted sustained release hemostasis can be carried out during endoscopic surgery.
Description
technical field [0001] The invention relates to the field of medical equipment and its preparation, in particular to a thrombin sustained-release endoscopic hemostatic clip and a preparation method of related medical equipment. Background technique [0002] At present, with the rapid development and innovation of medical technology, various medical methods such as endoscopic technology and minimally invasive technology have gradually become mainstream medical technologies. However, endoscopic and minimally invasive devices also bring some upper gastrointestinal Bleeding is a common digestive tract disease and a common surgical complication in endoscopic treatment. The traditional medical treatment methods for upper gastrointestinal bleeding mainly include local spraying or injection of hemostasis, intravenous application of hemostatic drugs, etc. At present, the targeted drug thrombin is widely used to locally act on the surface of the lesion under endoscopic hemostasis, and...
Claims
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IPC IPC(8): A61L31/08A61L31/02A61L31/16
CPCA61L31/022A61L31/086A61L31/16A61L2300/254A61L2300/418A61L2300/608A61L2420/08
Inventor 高峰高奇辉李磊
Owner 泰安市御翔医疗科技有限公司