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A preparation method of hydrophilic high-capacity ion exchange separation and purification microsphere material

An ion exchange and hydrophilic technology, which is applied in the field of preparation of hydrophilic high-capacity ion exchange separation and purification microsphere materials, can solve the problems of low separation efficiency and insufficient exchange capacity, and achieve high separation efficiency and high separation capacity. , the effect of excellent mechanical properties

Inactive Publication Date: 2019-08-23
PEKING UNIV SHENZHEN GRADUATE SCHOOL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the existing methods can prepare ion exchange resins with excellent mechanical properties and good separation capabilities, they still have certain specific adsorption capabilities for proteins and polypeptide macromolecules, low separation efficiency, and insufficient exchange capacity.

Method used

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  • A preparation method of hydrophilic high-capacity ion exchange separation and purification microsphere material
  • A preparation method of hydrophilic high-capacity ion exchange separation and purification microsphere material
  • A preparation method of hydrophilic high-capacity ion exchange separation and purification microsphere material

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preparation example Construction

[0033] Such as figure 1 As shown, a method for preparing a hydrophilic high-capacity ion-exchange separation and purification microsphere material according to an embodiment of the present invention includes: (1) conducting poly(styrene-divinylbenzene) microspheres with a porous structure The hydrophilic coating is modified to obtain poly(styrene-divinylbenzene) microspheres modified by the hydrophilic coating, which have no non-specific adsorption capacity for proteins and polypeptide molecules; (2) the hydrophilic coating Coating-modified poly(styrene-divinylbenzene) microspheres are dispersed in dioxane, and catalysts and epoxy functional monomers are added to react to obtain poly(styrene-divinylbenzene) polymer chains with polyhydroxyl structures. (ethylene-divinylbenzene) microspheres; and (3) dispersing poly(styrene-divinylbenzene) microspheres with polyhydroxyl structure macromolecular chains in water or dioxane, adding ion exchange function React monomers to obtain hy...

Embodiment 1

[0042] Such as figure 2 As shown, the preparation method of the ion-exchange separation and purification microsphere material of the present embodiment includes the following steps, the preparation of poly(styrene-divinylbenzene) microsphere hydrophilic coating, specifically:

[0043] 1. Take 10g of poly(styrene-divinylbenzene) microspheres with a particle size of 30μm and disperse them in 100mL of dioxane / water (volume ratio 1:1). After ultrasonic stirring to make them uniformly dispersed, add 10g of polyethylene Alcohol solution, stirred at room temperature for 3-5h.

[0044] 2. After the reaction is complete, filter with a sand core funnel of the corresponding specification, wash with water, and dry at a constant temperature of 60°C to constant weight after cleaning.

[0045] 3. Take 10g of the dried microspheres and disperse them in 100mL of water. After ultrasonic stirring to make them evenly dispersed, add 0.5g of glutaraldehyde and 10mL of 4mol / L KOH solution. After t...

Embodiment 2

[0047] Such as figure 2 As shown, the preparation method of the ion-exchange separation and purification microsphere material of the present embodiment includes the following steps, the preparation of poly(styrene-divinylbenzene) microsphere hydrophilic coating, specifically:

[0048] 1. Take 15g of poly(styrene-divinylbenzene) microspheres with a particle size of 30μm and disperse them in 150mL of dioxane / water (volume ratio 1:1). Sugar solution, stirred at room temperature for 3-5h.

[0049] 2. After the reaction is complete, filter with a sand core funnel of the corresponding specification, wash with water, and dry at a constant temperature of 60°C to constant weight after cleaning.

[0050] 3. Take 15g of the dried microspheres and disperse them in 150mL of water. After ultrasonic stirring to make them evenly dispersed, add 0.75g of glutaraldehyde and 10mL of 4mol / L KOH solution. After the reaction is complete, use a sand core funnel of the corresponding specification F...

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Abstract

The invention discloses a preparation method of a hydrophilic high-loading-capacity ion exchange separation and purification microsphere material. The method comprises the following steps of performing hydrophilic coating modification on poly(styrene-divinyl benzene) microspheres with porous structures to obtain hydrophilic coating modified microspheres; no nonspecific adsorption capability is realized on protein and polypeptide molecules; the hydrophilic coating modified microspheres are dispersed in dioxane; catalysts and epoxy functional monomers are added for reaction; microspheres with polyhydroxyl polymer chains are obtained; the microspheres with the polyhydroxyl polymer chains are dispersed into water or dioxane; ion exchange functional monomers are added for reaction; the hydrophilic high-loading-capacity ion exchange separation and purification microsphere material is obtained. The surface of the microsphere material does not have nonspecific adsorption capability on the protein and polypeptide molecules; the characteristics of high stability and high loading capacity are realized.

Description

technical field [0001] The invention relates to the technical field of ion exchange materials, in particular to a method for preparing a hydrophilic high-capacity ion exchange separation and purification microsphere material. Background technique [0002] Ion exchange resin is a polymer material that combines ion exchange functional groups on fine three-dimensional polymer particles to exchange and refine ionic substances dissolved in solution. That is to say, the mobile ions in the ion exchange resin exchange with other ions in the solution to achieve the removal of ionic substances. The performance and characteristics of ion exchange resins are determined by the type, density, crosslinking degree, specific surface area, etc. of ion exchange groups. [0003] The preparation and application of ion-exchange polymer microspheres is a cutting-edge and cross-emerging discipline in the world today, from bulk products such as conventional coatings and cosmetics to carriers for dr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J47/014
Inventor 任连兵陈静何洁滕超朱丽丽王勇
Owner PEKING UNIV SHENZHEN GRADUATE SCHOOL
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