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Rhizoma atractylodis macrocephalae formula granule preparation and quality standard identification detection method thereof

A formula granule and quality standard technology, which is applied in the field of Atractylodes macrocephala formula granule preparation and its quality standard identification and detection, to achieve the effect of easy portability and use, and simple preparation process

Inactive Publication Date: 2017-05-17
JIANGXI BAISHEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It brings a lot of inconvenience to the production and use of Atractylodes macrocephala and its preparations. Therefore, there is an urgent need to provide a specific method for the quality standard identification and detection of Atractylodes atractylodes formula granules and preparations.

Method used

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  • Rhizoma atractylodis macrocephalae formula granule preparation and quality standard identification detection method thereof
  • Rhizoma atractylodis macrocephalae formula granule preparation and quality standard identification detection method thereof
  • Rhizoma atractylodis macrocephalae formula granule preparation and quality standard identification detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1, the preparation of Atractylodes macrocephala formula granules and the identification and detection of quality standards,

[0027] Raw material source, the Atractylodes Rhizoma Atractylodes Rhizome of the present invention is Atractylodes Rhizoma Atractylodes Rhizome of Compositae Atractylodes macrocephala Formula granules made from the dried rhizome of Koidz.

[0028] The preparation method of Atractylodes macrocephala formula granules of the present invention is to add 1500 g of Atractylodes macrocephala to 8 times the amount of water, that is, 12000 g of water, decoct twice, control the decoction time for each time for 1.5 hours, filter, combine the filtrates, and concentrate under reduced pressure to The relative density at 60°C is 1.08-1.12. Add 360g of dextrin as an auxiliary material, mix well, filter, spray dry, and control the paste yield in the range of 31.5%-42.7%. Add appropriate amount of dextrin, mix well, and granulate. Made into 1000g, that i...

Embodiment 2

[0101] Atractylodes decoction pieces quality standard identification test, the test product described in this embodiment is Atractylodes decoction pieces. That is, the detection and identification of the following quality standards are all done for Baizhu decoction pieces.

[0102] 【Processing】Atractylodes macrocephala Atractylodes macrocephala Dried rhizomes of Koidz., remove impurities, wash, moisten thoroughly, cut into thick slices, and dry.

[0103] In addition to meeting the relevant provisions of "Atractylodes macrocephala" decoction pieces on page 103 of "Chinese Pharmacopoeia" 2015 Edition, this product should also meet the following provisions:

[0104] [Extracts] According to the hot dip method under the determination method of alcohol-soluble extracts ("Chinese Pharmacopoeia" 2015 edition four general rules 2201), with 60% ethanol as solvent, the extracts should not be less than 35.0%.

[0105] [Characteristic spectrum] Determination according to high performan...

Embodiment 3

[0114] For quality standard identification and testing of intermediates, the test substance described in this example is the intermediate. That is, the detection and identification of the following quality standards are all for intermediates.

[0115] 【Properties】This product is a light yellow to brown loose powder;

[0116] [Identification] Take 0.5g of this product, grind it finely, add 20ml of methanol, treat it with ultrasound for 30 minutes, filter, and take the subsequent filtrate as the test solution. Take another 0.5g of Atractylodes rhizome reference drug, add 30ml of water, boil for 20 minutes, evaporate the filtrate to dryness, add 20ml of methanol to the residue, and prepare the reference drug solution in the same way. According to the thin-layer chromatography ("Chinese Pharmacopoeia" 2015 edition four general rules 0502) test, draw 1μl of the control medicinal material solution and 1-2μl of the test solution on the same silica gel G thin-layer plate, and use chl...

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Abstract

The invention discloses a rhizoma atractylodis macrocephalae formula granule preparation and a quality standard identification detection method thereof. The rhizoma atractylodis macrocephalae formula granule preparation adopts rhizoma atractylodis macrocephalae or medicinal slices thereof as raw materials, and is prepared through the following steps of adding 1500g of rhizoma atractylodis macrocephalae into water with the mass being 8 to 10 times of the mass of the rhizoma atractylodis macrocephalae, decocting for two times, controlling the decoction time for 1 to 1.5 hours every time, filtering, combining filtrate, vacuum concentrating until the filtrate has the relative density ranging from 1.08 to 1.12 under a condition with the temperature being 60 DEG C, adding an auxiliary material, controlling the adding quantity of the auxiliary material to be 20 to 25 percent of the mass of the rhizoma atractylodis macrocephalae, uniformly mixing, filtering, spray drying, controlling the range of extraction amount ranging from 31.5 percent to 42.7 percent, then adding an appropriate amount of dextrin, uniformly mixing, carrying out granulation, and preparing to obtain 1000g of rhizoma atractylodis macrocephalae formula granule preparation. By adopting the processes such as extraction, evaporation, concentration and the like, the prepared rhizoma atractylodis macrocephalae formula granule preparation has a good medicinal efficacy, preferably reserves atractylenolide effective constituents in the preparation, has the efficacies on strengthening the spleen and stomach, and invigorating qi and moisturizing the lung, and is convenient to carry, store and use.

Description

[0001] Technical field: [0002] The invention belongs to the technical field of preparation, identification and detection of traditional Chinese medicines, in particular to an Atractylodes macrocephala formula granule preparation and a quality standard identification and detection method thereof. [0003] Background technique: [0004] Atractylodes macrocephala, recorded in the "Chinese Pharmacopoeia", has the effect of invigorating the spleen and stomach and benefiting lung qi. It is used for weak spleen and stomach, lack of food and loose stools, shortness of breath and cough, and limb fatigue. Atractylodes macrocephala is a kind of traditional Chinese herbal medicine commonly used in my country to invigorate the spleen and stomach, and benefit the lungs. It is usually used in the form of Chinese herbal medicine, while the use of Chinese patent medicines such as Atractylodes macrocephala formula granules is seldom used. [0005] At present, there is no preparation method and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/284A61K9/16A61P1/14A61P1/12A61P11/10A61P1/08A61P7/10A61P43/00A61P15/06G01N5/04G01N30/90G01N30/02
CPCA61K9/1652A61K36/284A61K2236/331A61K2236/39A61K2236/51G01N5/045G01N30/02G01N30/90Y02A50/30
Inventor 邱国旺彭绍平蔡良刘玉英杜小平
Owner JIANGXI BAISHEN PHARMA
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