Medicine for reducing side effect of fusidic acid in clinical use

A technology of fusidic acid and side effects, applied in the field of pharmacy, can solve problems such as adverse drug reactions, affecting the normal life of patients, allergic skin reactions, etc.

Inactive Publication Date: 2017-05-17
沂南县迎辉农业开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fusidic acid is one of the commonly used drugs for the treatment of acne vulgaris. Although it has certain curative effect, adverse drug reactions may occur, including contact dermatitis, rash, eczema, erythema, maculopapular rash, itching, skin allergic reactions, etc., rare adverse reactions Jaundice, purpura, epidermal necrosis, angioedema, etc.
Seriously affect the normal life of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0022] Embodiment 1: The medicament for reducing side effects of fusidic acid in clinical use includes component A and component B, the component A is fusidic acid cream, and the component B is a Chinese herbal medicine extract. Described Chinese herbal medicine extract is pulverized and mixed evenly by orchid vanilla 180g, Scutellaria barbata 200g, Scattered Flowers to leaves 170g, Four tiles to leaves 250g, Luffa rattan 180g, add 7 times of amount (weight multiple) 80% (volume percentage) ethanol , reflux extraction for 1.5h and filtration, then add 5 times the amount (weight multiple) of ethanol of the same concentration to the dregs, reflux extraction for 1h and filtration, combine two alcohol extracts, recover ethanol under reduced pressure, and concentrate to a relative density of 1.25( 50 ℃ thick paste), adding 4% coal tar (per 1 gram of thick paste adding 0.4ml of coal tar) made of paste; during use, the proportion of component A and component B according to the weight ...

Embodiment approach 2

[0023] Embodiment 2: The medicament for reducing the side effects of fusidic acid in clinical use includes component A and component B, the component A is fusidic acid cream, and the component B is a Chinese herbal medicine extract, so The Chinese herbal medicine extract is made from 200g of orchid vanilla, 210g of Scutellaria barbata, 185g of scattered flowers on opposite leaves, 260g of four tiles on opposite leaves, and 190g of loofah vine. The preparation method is the same as that of Embodiment 1.

Embodiment approach 3

[0024] Embodiment 3: The medicament for reducing the side effects of fusidic acid in clinical use includes component A and component B, the component A is fusidic acid cream, and the component B is a Chinese herbal medicine extract, so The Chinese herbal medicine extract is prepared by pulverizing and mixing 220g of orchid vanilla, 220g of Scutellaria barbata, 200g of scattered flowers on opposite leaves, 270g of four tiles on opposite leaves, and 200g of loofah vine. The preparation method is the same as that of Embodiment 1.

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PUM

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Abstract

The invention discloses a medicine for reducing the side effect of fusidic acid in clinical use, and belongs to the technical field of medicines for external use. The medicine for reducing the side effect of the fusidic acid in clinical use comprises a component A and a component B, wherein the component A is fusidic acid cream, and the component B is a Chinese herb extract. The medicine disclosed by the invention is obtained by fully mixing and uniformly stirring the component A and the component B according to a weight ratio of 1:2. A clinical experiment shows that the medicine has an outstanding treating effect on acne vulgaris and can reduce the side effect of the fusidic acid in clinical use.

Description

technical field [0001] The invention relates to the technical field of medicaments, in particular to a medicament for reducing side effects of fusidic acid in clinical use. Background technique [0002] The onset of acne vulgaris and the high level of androgen in puberty lead to increased sebum production, and hyperkeratosis of the hair follicle orifice and sebaceous gland duct leads to poor sebum excretion. Under the action of oxidative stress, it is hydrolyzed into free fatty acids, stimulates non-specific inflammatory reactions in and around hair follicles, induces the production of inflammatory mediators such as oxygen free radicals and chemokines, chemoattracts neutrophils into hair follicles, releases hydrolytic enzymes, and damages hair follicle walls. Bacterial infection causes inflammation in addition, forms acne, pimple, pustule, even nodules, abscess and cyst etc. pleomorphic skin lesion. Current treatment mainly includes topical, oral antibiotics and retinoic ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61P17/10A61K31/56
CPCA61K36/85A61K31/56A61K36/185A61K36/35A61K36/42A61K36/539A61K2236/333A61K2236/39A61K2236/51
Inventor 程祥永
Owner 沂南县迎辉农业开发有限公司
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