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Three-minister suspension and preparation method thereof

A technology of suspension and suspending agent, which is applied in the fields of pharmaceutical formulation, liquid delivery, emulsion delivery, etc., can solve the problems of Sanchen powder, such as bitter taste, obvious gritty feeling, and difficulty in adapting to the requirements of children, and achieve obvious therapeutic effect , change the bitterness, the effect of stable quality

Inactive Publication Date: 2017-05-24
NINGXIA DUOWEI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sanchen powder has a bitter taste, and the feeling of grit is obvious after taking it, so it is difficult to adapt to the requirements of children.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1: The prescription and preparation technology of Sanchen suspension

[0039] Tianzhuhuang: 0.50g,

[0040] Safflower: 0.395g,

[0041] Artificial bezoar: 0.005g,

[0042] Xanthan gum: 0.01g,

[0043] Mannitol: 0.06g,

[0044] Potassium sorbate: 0.005g,

[0045] Purified water: 10ml.

[0046] Preparation:

[0047] (1) Pulverize Tianzhuhuang and safflower through a 150-mesh sieve, and mix Tianzhuhuang, safflower, and artificial bezoar in equal increments to make Sanchen powder.

[0048] (2) Weigh 0.06g of mannitol and 0.01g of xanthan gum, mix Sanchen powder and mannitol in equal increments, and mix the mixed powder and xanthan gum in equal increments.

[0049] (3) Measure 10ml of purified water and slowly add it to the mixed powder, stir while adding, and finally weigh 0.005g of potassium sorbate and add it to the suspension and shake well.

Embodiment 2

[0050] Embodiment 2: the prescription and preparation technology of Sanchen suspension

[0051] Tianzhuhuang: 0.85g,

[0052] Safflower: 0.20g,

[0053] Artificial bezoar: 0.001g,

[0054] Polysorbate: 0.03g,

[0055] Mannitol: 0.043g,

[0056] Sodium benzoate: 0.001g,

[0057] Purified water: 10ml.

[0058] Preparation:

[0059] (1) Pulverize Tianzhuhuang and safflower through a 150-mesh sieve, and mix Tianzhuhuang, safflower, and artificial bezoar in equal increments to make Sanchen powder.

[0060] (2) Weigh 0.043g of mannitol and 0.03g of polysorbate respectively, mix Sanchen powder and mannitol in equal increments, add polysorbate to the mixed powder and stir to mix evenly.

[0061] (3) Measure 10ml of purified water and slowly add it to the mixed powder, stir while adding, and finally weigh 0.001g of sodium benzoate, add it to the suspension and shake well to get ready.

Embodiment 3

[0062] Embodiment 3: the prescription and preparation technology of Sanchen suspension

[0063] Tianzhuhuang: 0.95g,

[0064] Safflower: 0.10g,

[0065] Artificial bezoar: 0.0005g,

[0066] Sodium carboxymethylcellulose: 0.005g,

[0067] Lactose: 0.064g,

[0068] Ethylparaben: 0.0055g,

[0069] Purified water: 10ml.

[0070] Preparation:

[0071] (1) Pulverize Tianzhuhuang and safflower through a 150-mesh sieve, and mix Tianzhuhuang, safflower, and artificial bezoar in equal increments to make Sanchen powder.

[0072] (2) Weigh 0.064g of lactose and 0.005g of sodium carboxymethyl cellulose, mix the Sanchen powder and lactose in equal increments, and mix the mixed powder and sodium carboxymethyl cellulose in equal increments uniform.

[0073] (3) Measure 10ml of purified water and slowly add it to the mixed powder, stir while adding, and finally weigh 0.0055g of ethyl p-hydroxybenzoate and add it to the suspension and shake well.

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PUM

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Abstract

The invention relates to a three-minister suspension and a preparation method thereof. The preparation method comprises the steps: adding a main medicine three-minister powder composed of concretio silicea bambusae, safflower and artificial bezoar and a flavoring agent and a suspending agent in an equivalent progressive increase manner, mixing, then slowly adding a diluents, shaking, and finally adding a flavoring antibacterial agent and shaking evenly to obtain the product. The three-minister suspension is a medicinal preparation suitable for children with pulmonary heat and all fever; compared with a similar drug three-minister powder, the three-minister suspension is more suitable for children to take, changes the bitter feeling and gritty feeling when the powder is taken, and is easy to absorb, stable in quality during storage, and obvious in treatment effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a sanchen suspension and a preparation method thereof. Background technique [0002] Sanchensan originated from ancient Tibetan prescriptions, which were first recorded in the Tibetan medicine masterpiece "Lantabu", and are now collected in the first volume of Tibetan medicine in "Drug Standards of the Ministry of Health". The first choice Tibetan medicine for diseases. The main ingredients in the prescription of Sanchen Powder are Tianzhuhuang, safflower, and artificial bezoar. Among them, Tianzhuhuang is a lump of exudate from the stalks of grass plants such as Qingpi Bamboo or Huasilao Bamboo. The powder has a gritty feel. Tianzhuhuang Clearing away heat and dispelling phlegm, cooling heart and relieving convulsions, mainly treating coma and delirium due to febrile disease, apoplectic phlegm confusion, convulsions and convulsions in children,...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K9/10A61P11/00A61P29/00A61K35/413
CPCA61K36/899A61K9/10A61K35/413A61K36/286A61K47/26A61K2300/00
Inventor 王宏福陈德纲王春红白洁王伟鹏
Owner NINGXIA DUOWEI PHARMA
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