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Multifunctional bioreactor used for cell culture and cell sorting

A bioreactor and cell culture technology, applied in the field of multifunctional bioreactors, can solve the problems that affect the wide application of cell biotechnology, cannot be high-efficiency, large-scale, diverse types of cell culture, etc., to reduce cell pollution and the risk of target cell damage and death, reducing the risk of damage and death, and improving efficiency

Pending Publication Date: 2017-05-24
NANJING XINNUODAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The various cell culture methods listed above all have some defects and limitations in principle, and cannot realize the cultivation of various types of cells with high efficiency, large scale and diversity, thus affecting the large-scale development of cell biotechnology in society widely used

Method used

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  • Multifunctional bioreactor used for cell culture and cell sorting
  • Multifunctional bioreactor used for cell culture and cell sorting
  • Multifunctional bioreactor used for cell culture and cell sorting

Examples

Experimental program
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Effect test

Embodiment 1

[0074] The three-dimensional structure of ZYX bioreactor M1 of the present invention is as follows figure 1 , mainly consists of three module parts, such as figure 2 shown. It includes a control system 1, an inversion device 2, a cell culture container 3 and the like.

[0075] Such as image 3 As shown, in the control system, it includes: main box 1-1, display screen 1-2, warning light 1-3, panel 1-4, computer host switch 1-5, boom bracket 1-6, waste liquid bag 1-7, medium storage bag 1-8, code reader antenna 1-9, boom positioning ring 1-10, silicone catheter 1-11, main controller 1-12, main box rear cover 1-13, solid Wire slot 1-14, first switching power supply 1-15, second switching power supply 1-16, mounting plate 1-17, computer host 1-18, host fixing plate 1-19, cooling fan 1-20, main chassis power supply Switch 1-21, protection switch 1-22, power interface 1-23, network cable interface 1-24, conduit end cover 1-25, shock absorbing pad 1-26, peristaltic pump 1-27, ma...

Embodiment 2

[0082] ZYX bioreactor S20 of the present invention is mainly made up of three module parts, as Figure 8 shown. It consists of control system I, turning device II and cell culture container III.

[0083] Such as Figure 9 As shown, in the control system, it includes: silicone conduit Ⅰ-1, main box front cover Ⅰ-2, hinge Ⅰ-3, front cover perspective plate Ⅰ-4, display screen Ⅰ-5, main engine switch Ⅰ-6, main engine Box Ⅰ-7, host installation plate Ⅰ-8, host Ⅰ-9, host fixing plate Ⅰ-10, main chassis rear cover Ⅰ-11, cooling fan Ⅰ-12, chassis lock Ⅰ-13, first switching power supply Ⅰ -14, the second switching power supply Ⅰ-15, the alarm Ⅰ-16, the main controller Ⅰ-17, the terminal block Ⅰ-18, the power supply installation board Ⅰ-19, the perfusion drive module Ⅰ-20, the module installation board Ⅰ-21 , Syringe I-22, Protection Switch I-23, Main Box Power Switch I-24, Power Interface I-25, First Communication Line Terminal I-26, Shock Pad I-27, Signal Line I-28. During the ov...

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Abstract

The invention relates to a multifunctional bioreactor used for cell culture and cell sorting. The multifunctional bioreactor comprises a turnover device and a cell culture vessel, wherein the turnover device contains a turnover support which can operate around a space axis and a magnetic field generating device in physical connection with the turnover device, the cell culture vessel is detachably fixed on the turnover support, the cell culture vessel is located on the space axis or an extension line thereof and operates along with the turnover support according to certain rules and tracks, the end face of the cell culture vessel is close to the magnetic field generating device, and the magnetic field generating device can control change of a magnetic field surrounding the periphery and interior of the cell culture vessel. The multifunctional bioreactor provided by the invention has the advantages that co-culture on adherent cells and suspension cells is carried out without replacing the vessel, stirring inside a culture solution is realized by virtue of movement of carriers in the vessel in a magnetic field environment, cell contamination, target cell damage and death risk are reduced, and the vessel can be taken as a bearing material of the adherent cells, so that cell culture efficiency is greatly improved.

Description

technical field [0001] The invention relates to a bioengineering technical equipment, which is a multifunctional bioreactor related to cell culture and cell sorting. Background technique [0002] With the development of science and technology, modern cell biology engineering technology has been widely used in all aspects of social production. And with the rapid development and application of cell biology engineering technology in multiple industries such as biology, medical treatment, and beauty, there is an urgent need for large-scale cell culture in order to obtain a large number of useful cell expression products. And adopt the culture method of glass bottle static or rotating bottle, the cell quantity and its secretory product that it cultivates can't satisfy the needs of various industries of society already. After years of technical research and development, various types of bioreactors have been developed so far, such as roller bottle bioreactors, agitated suspension...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M3/00C12M3/02C12M1/02C12M1/00
CPCC12M27/00C12M27/14C12M47/04
Inventor 张永新叶治家朱融晖谭玉麟王修林王香寒徐张展刘小浩
Owner NANJING XINNUODAN BIOTECH
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