Cerebral blood oxygen detection signal processing method and system

A signal processing and detection system technology, applied in the field of cerebral blood oxygen detection, can solve the problems of high operating voltage, reduced sensitivity, large volume, etc., to achieve the effect of improving accuracy, reducing the effect of baseline drift and high-frequency noise

Inactive Publication Date: 2017-05-31
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PMTs are very sensitive to overexposure, operate at high voltages, and are bulky; APDs greatly reduce the sensitivity

Method used

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  • Cerebral blood oxygen detection signal processing method and system
  • Cerebral blood oxygen detection signal processing method and system
  • Cerebral blood oxygen detection signal processing method and system

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Experimental program
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Embodiment 1

[0057] Such as figure 1 As shown, the present invention provides a signal processing method for cerebral blood oxygen detection, which includes the following steps:

[0058] S10, collecting analog optical density current signals not absorbed by brain tissue hemoglobin, performing primary processing on the analog optical density current signals, and outputting digital optical density voltage signals;

[0059] S20, performing secondary processing on the optical density voltage signal to denoise;

[0060] Among them, such as figure 2 As shown, secondary processing includes the following steps:

[0061] S21, improving the overall complete empirical mode decomposition of the optical density voltage signal, and outputting all modal components;

[0062] S22. Perform permutation entropy calculation for each modal component, select a threshold, and perform signal reconstruction.

[0063]In the above embodiments, the primary processing is used to convert the analog optical density ...

Embodiment approach

[0079] As another embodiment of the present invention, the signal processing method for cerebral blood oxygen detection further includes the following steps:

[0080] S30, based on the denoised optical density voltage signal, using the modified Lambert-Beer law to calculate the blood oxygen saturation of the brain tissue. Such as Figure 5 As shown, specifically, the following steps are included:

[0081] S31, based on the modified Lambert-Beer law, calculate the hemoglobin concentration and blood oxygen saturation:

[0082] Among them, OD is the optical density; I Out Indicates the transmitted light intensity; I In Indicates the intensity of incident light; ε indicates the molar absorptivity; C indicates the concentration of light-absorbing substances; L is the effective path length;

[0083]

[0084] S32, bring in the denoised optical density voltage signal, and calculate the oxygenated hemoglobin concentration and deoxyhemoglobin concentration C Hb ;

[0085] S...

Embodiment 2

[0088] On the basis of the signal processing method of cerebral blood oxygen detection provided in embodiment 1, such as Figure 6 As shown, the present invention provides a cerebral blood oxygen detection system, comprising:

[0089] Optical density signal collection module 10, which is used to collect analog optical density current signals that are not absorbed by brain tissue hemoglobin;

[0090] Signal processing and operation module 20, which is connected to the optical density signal acquisition module for communication, and is used to perform primary processing, secondary processing, and calculation processing of brain tissue blood oxygen saturation on the analog optical density current signal; and,

[0091] A display module 30, which is connected to the signal processing and computing module for displaying the blood oxygen saturation of the brain tissue;

[0092] Among them, the first-level processing includes sequential current-voltage conversion, low-pass filtering,...

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Abstract

The invention discloses a cerebral blood oxygen detection signal processing method. The method includes steps: acquiring analog optical density current signals unabsorbed by brain tissue hemoglobin, and subjecting the analog optical density current signals to primary treatment to output digital optical density voltage signals; subjecting the optical density voltage signals to secondary processing for denoising. Secondary processing includes steps: subjecting the optical density voltage signals to modified total complete empirical mode decomposition, and outputting all mode components; subjecting each mode component to permutation entropy calculation, and selecting a threshold to perform signal reconstruction. Denoising of the optical density voltage signals is realized by means of modified total complete empirical mode decomposition and permutation entropy, influences of baseline drift and high-frequency noise are effectively reduced, and data precision is improved.

Description

technical field [0001] The present invention relates to the technical field of cerebral blood oxygen detection, and more specifically, the present invention relates to a signal processing method and detection system for cerebral blood oxygen detection. Background technique [0002] Cerebral blood oxygen detection based on near-infrared spectroscopy is a non-invasive detection technology widely used in the study of brain function. [0003] In the prior art, during the sampling process, the baseline drift and high-frequency noise caused by interference such as physiological activities of the human body and random noise will seriously affect the accuracy of the data. [0004] In addition, in the current equipment, most of the detectors used for cerebral blood oxygen detection based on near-infrared spectroscopy technology are photomultiplier tubes (Photomultiplier Tubes, PMTs) or photodiodes (Photo-Diodes, APDs) as detectors. However, PMTs are very sensitive to overexposure, o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/1455A61B5/00
Inventor 吴凯戴亚康佟宝同赵凌霄刘燕
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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