Preparation method for compound calcium carbonate/ vitamin D3 tablet

Abstract

The invention provides a preparation method for a compound calcium carbonate / vitamin D3 tablet. A processing technology step of sweet orange powder essence adding during wet process granulation is changed so as to reduce a fine powder amount in particles after total blending is carried out and change the taste of a product. The compound calcium carbonate / vitamin D3 tablet obtained by the preparation method is convenient in preparation, a patient who takes the tablet can easily accept the tablet, and the prepared compound calcium carbonate / vitamin D3 tablet has the characteristics of convenience in carrying, storage and transportation and feasible preparation technology and is suitable for mass production. The prepared compound calcium carbonate / vitamin D3 tablet has the advantages of integral and bright appearance and even color and has better evenness energy and higher dissolution rate. Meanwhile, compared with an existing production technology, the preparation method is characterized in that the service life of the punch of each tablet press is prolonged for 6 months under the same yield, and the production cost of an enterprise is lowered.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a preparation method of composite calcium carbonate / vitamin D3 tablets. Background technique [0002] Calcium is the inorganic element with the highest content in the human body, accounting for about 2% of body weight (about 1200-1400g). Under the regulation of parathyroid hormone, calcitonin and vitamin D, the amount of calcium stored in the body is relatively constant, and 99% of calcium Exist in bones and teeth. Bones are the scaffolds that make up the human body and the basic storage of calcium in the body; the other 1% of calcium exists in soft tissues, extracellular fluid and blood, collectively known as miscible calcium pools, which are kept with bone calcium. Homeostasis, necessary to maintain the normal state of all cells. Calcium plays an extremely important physiological regulatory role in physiological processes such as nerve and muscl...

AI Technical Summary

Problems solved by technology

In the current process of pharmaceuticals, 50% of the prescription amount of sweet orange powder essence is added to granulate together with other raw materials and auxiliary materials during wet granulation, and the remaining 50% is added during total mixing, because the amount of essence added during total mixing is large, resulting in There are more fine powders in the granules after the total blending, and the taste of the product is poor, and because there are more fine powders in the granules after the total blending, the tablet often uncovers or cracks during tablet compression, so it is necessary to increase the pressure of the tablet press, and The tablet press is in a state of high pressure for a long time, which will cause certain damage to the tablet press and shorten the service life of the tablet press and the punch

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