A kind of photoelectrochemical biosensor and preparation method thereof
A biosensor and photoelectrochemical technology, which is applied in the field of biosensing, can solve the problems that photoelectrochemical biosensors are not easy to miniaturize, and achieve the effects of simple structure, high sensitivity, and small device size
Active Publication Date: 2019-03-26
SHENZHEN UNIV
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Problems solved by technology
[0004] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a photoelectrochemical biosensor and a preparation method thereof, thereby further improving the sensitivity of the photoelectrochemical biosensor and solving the problem that the existing photoelectrochemical biosensor is not easy to miniaturize
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Embodiment 1
[0047] Example 1 Photoelectrochemical DNA sensor based on organic electrochemical transistor
[0048] Principle: The gate electrode is an ITO electrode assembled with cadmium sulfide quantum dots (CdS QDs). Under light conditions, when the energy of the light is greater than the energy required for the electron transition in CdS, the electrons in the valence band in CdS will transition to the conduction band. , forming electron-hole pairs. When the electrons in the conduction band are injected into the electrode, the electron donor in the solution provides electrons to the holes in the valence band, which will form a photocurrent. The generation of this current will reduce the potential of the electrolyte / gate electrode interface, thereby increasing the applied on the OECT device. effective gate voltage. The channel current of OECT is given by the following equation:
[0049]
[0050] where q stands for electron charge, µ stands for hole mobility, represents the initial...
Embodiment 2
[0062] Example 2 Photoelectrochemical immunosensor based on organic electrochemical transistor
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Abstract
A photoelectrochemical biosensor and a preparation method therefor. The photoelectrochemical biosensor comprises: an electrolytic cell (1), electrolyte (2) provided in the electrolytic cell (1), an organic electrochemical transistor (9) provided in the electrolytic cell (1), and a gate electrode (3) provided in the electrolytic cell (1); the organic electrochemical transistor (9) comprises a substrate (5), a source electrode (7) and a drain electrode (8) provided on the substrate (5), and an organic semiconductor film layer (6) applied over the substrate (5) and connected to the source electrode (7) and the drain electrode (8); the gate electrode (3) is modified with a photoelectrically active semiconductor material (4) serving as a sensitive functional layer of the sensor. The photoelectrochemical biosensor has extremely high sensitivity, a simple structure, and a small device size, and therefore, the problem of difficulty in miniaturization of the photoelectrochemical biosensor is resolved. The photoelectrochemical biosensor is generally applicable in the field of biological detection, and can be widely applied to biosensors such as enzyme biosensors and cell sensors, besides DNA sensors and immunosensors.
Description
technical field [0001] The invention relates to the technical field of biosensing, in particular to a photoelectrochemical biosensor and a preparation method thereof. Background technique [0002] Photoelectrochemical (PEC) biosensing technology is a biosensing technology developed on the basis of electrochemical analysis methods. Due to its high sensitivity, low price and simple equipment, it has been widely used in enzyme biosensing. , DNA sensing, immune sensing, and cell sensing and other biosensing. The detection principle of PEC is based on the biorecognition between the recognition element and the target molecule under light to produce a change in the corresponding electrical signal. At present, the detection of the signal in the PEC biosensor is mainly through the electrochemical workstation, and a three-electrode test system consisting of a working electrode, a reference electrode, and a counter electrode is established to detect the magnitude of the photocurrent. ...
Claims
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IPC IPC(8): G01N27/414
CPCG01N27/4145
Inventor 林鹏宋家俊魏伟伟柯善明曾燮榕
Owner SHENZHEN UNIV