Methods, reagents and cells for biosynthesizing compounds

A functionalization and conversion technology, applied in biochemical equipment and methods, organic chemistry, oxidoreductase, etc., can solve problems such as no reports
CN106795531AInactive Publication Date: 2017-05-31INVISTA TEXTILES (U K) LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INVISTA TEXTILES (U K) LTD
Publication Date
2017-05-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

This document describes biochemical pathways for producing 2,3-dehydroadipyl-CoA methyl ester from precursors such as 2-oxoglutarate using one or more of a fatty acid O-methyltransferase, a thioesterase, a CoA-transferase and a CoA ligase, as well as recombinant hosts expressing one or more of such enzymes. 2,3-dehydroadipyl-CoA methyl ester can be enzymatically converted to adipyl-CoA using a trans-2-enoyl-CoA reductase, and a methylesterase, which in turn can be enzymatically converted to adipic acid, 6-aminohexanoate, 6-hydroxyhexanoate, caprolactam, hexamethylenediamine, or 1,6-hexanediol.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of US Application Nos. 62 / 012,674 and 62 / 012,735, both filed June 16, 2014, the disclosures of which are incorporated herein by reference in their entirety. technical field

[0003] The present invention relates to a method for masking a carbon chain aliphatic backbone functionalized with a terminal carboxyl group in a recombinant host using a polypeptide having fatty acid O-methyltransferase activity. The present invention also relates to a method for biosynthesizing 2,3-dehydroadipyl CoA methyl ester in a host using one or more of: (i) a polypeptide having fatty acid O-methyltransferase activity, (ii) a polypeptide having Polypeptides with thioesterase activity or CoA transferase activity, or (iii) polypeptides having CoA ligase activity, and recombinant host cells expressing one or more such exogenous enzymes. The present invention also relates to the conversion of 2,3-dehydroadipy...

Claims

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