Method for preparing freeze-dried preparation in any shape and product thereof

Abstract

The invention relates to a method for preparing a freeze-dried preparation in any shape and a product made according to the method, and particularly relates to a preparation method of a freeze-dried preparation which is prepared and obtained through sufficiently agitating and making a freeze-dried preparation stock solution or freeze-dried preparation water into a smoothie during refrigeration, capably further mixing raw and auxiliary materials into the smoothie and then loading an obtained mixture into a certain mold to carry out freeze drying, is in any shape and mainly contains an active component and a binder, and a product made according to the method.

Description

technical field [0001] The present invention relates to a kind of method for preparing the freeze-dried preparation of any shape and the product made according to the method, particularly relate to a kind of smoothie that can be made by fully stirring water or the stock solution of freeze-dried preparation when freezing, and can further make The preparation method of the freeze-dried preparation mainly containing active ingredients and binders prepared by mixing the raw and auxiliary materials into a smoothie, and then filling it into a certain mold for freeze-drying, and the product obtained by this method . Background technique [0002] Freeze-drying excipient technology refers to adding a skeleton support agent and a binder to a flowable liquid, semi-solid or solid active ingredient, or the flowable liquid, semi-solid or solid itself contains a binder and a skeleton The support agent is then poured into a molding mold and shaped by a freeze-drying process. The preparatio...

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Problems solved by technology

[0004] Most of the lyophilized excipients on the market are single in form, and the molds used are traditional moulds, i.e. common groove molds. This traditional lyophilized excipient and its preparation method have the following disadvantages:

[0005] (1) The shape of the preparation is single. The reason is that the shape of the mold is fixed, and it can only be demoulded without demoulding or from one direction. No demoulding means that it is molded directly in a certain shape of packaging material, so it is rare to be spherical, Due to special shapes such as ellipsoid and irregular sphere, it is difficult to make special-shaped freeze-dried excipients due to traditional preparation methods

[0006] (2) The prepared tablet has sharp-edged edges, and many tablets with sharp-edged edges obtained after demolding enter the same package together and are prone to abrasion between the sharp-angled edges, resulting in inaccurate drug dosage

[0007] (3) Because of unidirectional filling, it is difficult to become a multi-layer structure, therefore, the preparation structure is single

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