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Application of ginsenoside Rg3 for treating acute myocardial infarction

A ginsenoside, acute myocardial infarction technology, applied in the field of medicine, can solve problems such as increasing myocardial contractility

Inactive Publication Date: 2017-06-13
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although, 200510078482.3 (CN1879640A) discloses the use of ginsenoside Rh2, Ck and Rg3 in increasing myocardial contractility, but there is no literature report that ginsenoside CK can be used for the treatment of acute myocardial infarction. Contraction force is irrelevant, therefore, CN1879640A has nothing to do with this application, and the present invention is innovative

Method used

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  • Application of ginsenoside Rg3 for treating acute myocardial infarction
  • Application of ginsenoside Rg3 for treating acute myocardial infarction
  • Application of ginsenoside Rg3 for treating acute myocardial infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Experimental materials

[0027] 1.1 Medicinal materials

[0028] Ginsenoside Rg3 (molecular weight 622.44, HPLC purity ≥ 99%, Institute of Traditional Chinese Medicine); Danshen injection (purchased from Shanghai Lvgu Pharmaceutical, batch number: 1505031);

[0029] 1.2 Experimental animals

[0030] SD rats weighing 220±20 g were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, animal certificate number: SYXK (Shanghai) 2008-0016. Placed in a conventional feeding environment, free access to food and water.

[0031] 2. Method:

[0032] Model making method: 30 SD rats (provided by the Animal Experiment Center of Shanghai University of Traditional Chinese Medicine), body weight: 220-270g. Rats were anesthetized with pentobarbital (35mg / kg), fixed in supine position; median neck incision was made, the trachea was separated, tracheotomy was performed, breathing tube was inserted, and the frequency and tidal volume of t...

Embodiment 2

[0052] A pharmaceutical preparation of ginsenoside Rg3, which is a medicament made from the following raw materials in weight ratio:

[0053]

[0054] Get ginsenoside Rg3 and dissolve in a small amount of water; microcrystalline cellulose, mannitol, and sodium carboxymethyl starch are passed through a 100-mesh sieve and mixed evenly, add ginsenoside Rg3 solution and fully stir, 2% hydroxyethyl methylcellulose solution is Soft material made of binder, pass through 80-mesh sieve to make granules, wet granules are air-dried in an oven at 40°C; dry granules are granulated through 80-mesh sieve, mixed with calcium stearate, and filled into capsules.

Embodiment 3

[0056] A pharmaceutical preparation of ginsenoside Rg3, which is a medicament made from the following raw materials in weight ratio:

[0057]

[0058] Get ginsenoside Rg3 and dissolve in a small amount of water; microcrystalline cellulose, mannitol, and sodium carboxymethyl starch are passed through a 100-mesh sieve and mixed evenly, add ginsenoside Rg3 solution and fully stir, 2% hydroxyethyl methylcellulose solution is Binder made of soft material, pass through 80-mesh sieve to make granules, wet granules are air-dried in oven at 40°C; dry granules are granulated through 80-mesh sieve, and compressed into tablets.

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PUM

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Abstract

The invention relates to the field of medicine, in particular to medical application of ginsenoside Rg3. The ginsenoside Rg3 can be used for preventing and treating acute myocardial infarction.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a therapeutic use of ginsenoside Rg3 for anti-myocardial infarction. Background technique [0002] Acute myocardial infarction (AMI) refers to the acute necrosis of part of the myocardium caused by persistent and severe myocardial ischemia. Acute myocardial infarction refers to the acute occlusion of the coronary artery, interruption of blood flow, resulting in ischemic necrosis of the local myocardium. Acute myocardial infarction is a severe type of coronary heart disease. The basic cause is coronary atherosclerosis, resulting in severe stenosis of the lumen and insufficient blood supply to the myocardium, while the collateral circulation is not fully established. On this basis, once the blood supply is further sharply reduced or interrupted, resulting in severe and persistent acute ischemia of the myocardium for more than 1 hour, myocardial infarction can occur. Clinically, it often m...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P9/10
Inventor 王峥涛高波鞠政财张二云李佳杨莉吴晓俊
Owner SHANGHAI UNIV OF T C M
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