Process system for preparing ethambutol hydrochloride

Abstract

The invention relates to a process system for preparing ethambutol hydrochloride. The process system comprises, in an upstream-to-downstream arrangement, comprises a reaction kettle (1), a distillation kettle (2), a dissolving kettle (3) and a press filter (4), and also a recovery tank (5) which is located downstream of the distillation kettle (2), a collection tank (6) which is located downstream of the press filter (4), and a nitrogen protection device comprising a nitrogen inlet pipe (7), and pressure alarm devices (10). The nitrogen inlet pipe (7) is connected with the top of the reaction kettle (1) by means of a pipe, and also connected with a blowdown pipe (8) and a discharge pipe (9) of the reaction kettle (1) by means of pipes. The pressure alarm devices (10) are located on a connecting pipe between the nitrogen inlet pipe (7) and the blowdown pipe (8) and on a connecting pipe between the nitrogen inlet pipe (7) and the discharge pipe (9). The process system is applicable to process preparation of ethambutol hydrochloride.

Description

technical field [0001] The invention relates to a chemical process, in particular to a process device for preparing ethambutol hydrochloride. Background technique [0002] Ethambutol hydrochloride interferes with the DNA and RNA synthesis of Mycobacterium tuberculosis, has a strong inhibitory effect on Mycobacterium tuberculosis in the growth and reproduction stage, and has no cross-resistance with other anti-tuberculosis drugs. Long-term use can slowly develop drug resistance. It is clinically used for patients resistant to streptomycin or isoniazid. Combined with rifampicin or isoniazid, it can enhance the efficacy and delay the emergence of drug resistance, and treat various types of active tuberculosis. In the process of preparing ethambutol hydrochloride, there is a chlorinated dangerous process, and chlorinated hydrocarbons can form explosive mixtures with air and oxygen, which are prone to explosion, leakage of toxic materials, poor control of process indicators or ...

AI Technical Summary

Problems solved by technology

In the process of preparing ethambutol hydrochloride, there is a chlorinated dangerous process, and chlorinated hydrocarbons can form explosive mixtures with air and oxygen, which are prone to explosion, leakage of toxic materials, poor control of process indicators or improper operation, resulting in out-of-control reactions ACCIDENT

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