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A method for dewaxing pupae oil α-ethyl linolenate bulk drug and production method of pupae oil α-ethyl linolenate bulk drug

A production method and technology of ethyl ethyl ester, applied in the field of pharmacy, can solve the problems of time-consuming, unsatisfactory effect, complexity and the like, and achieve the effects of reducing production cost, good effect and simple method

Active Publication Date: 2020-01-07
北京百慧生化制药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there are solvent dewaxing, urea dewaxing, molecular sieve dewaxing, etc. Some of these methods are complicated, some are time-consuming, and some have unsatisfactory effects, and new methods need to be found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 prepares dewaxed pupal oil

[0030] 10kg of waxy pupae oil containing about 25% is added with ethanol aqueous solution. The aqueous ethanol solution is prepared by dissolving 0.9kg of NaOH in 6kg of aqueous ethanol (weight ratio ethanol:water=1:1). After stirring at a temperature of 60° C. for 30 minutes, the layers were statically separated, the sediment and water in the lower layer were discarded, and the oily matter in the upper layer was collected to obtain about 8 kg of dewaxed pupal oil. The effect of residual wax on inclusion content decreased from 25% to about 2%.

Embodiment 2

[0031] Embodiment 2 prepares dewaxed pupal oil

[0032] 10kg of waxy pupae oil containing about 25% is added with ethanol aqueous solution. The ethanol aqueous solution is prepared by dissolving 1.4kg of NaOH in 6kg of ethanol aqueous solution (weight ratio ethanol:water=1:1). After stirring at a temperature of 75° C. for 20 minutes, the layers were statically separated, the sediment and water in the lower layer were discarded, and the oily matter in the upper layer was collected to obtain about 7.5 kg of dewaxed pupal oil. The effect of residual wax on inclusion content decreased from 25% to about 1.4%.

Embodiment 3

[0033] Embodiment 3 prepares dewaxed pupal oil

[0034] 10kg of waxy pupae oil containing about 18% is added with ethanol aqueous solution. The ethanol aqueous solution is prepared by dissolving 1kg of NaOH in 6kg of ethanol aqueous solution (weight ratio ethanol:water=1:1). After stirring at a temperature of 70° C. for 25 minutes, the layers were statically separated, the sediment and water in the lower layer were discarded, and the oily matter in the upper layer was collected to obtain about 8 kg of dewaxed pupal oil. The effect of residual wax on inclusion content decreased from 18% to about 0.8%.

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Abstract

The invention provides a novel method for removing wax in crude pupal fat of a pupal fat alpha-linolenic acid ethyl ester crude drug. 7-20% NaOH is added into the crude pupal fat and prepared into NaOH-ethanol water solution according to the weight ratio of NaOH-ethanol water solution=(10-25):100 in advance, the NaOH-ethanol water solution is stirred for 20-30 minutes at the temperature of 60-75 DEG C, static layering is performed, upper oily substances are collected, and lower deposits and water are discarded to obtain dewaxed pupal fat. The wax in the crude pupal fat is removed by an alkaline process, the problem of incapability of separating the pupal fat alpha-linolenic acid ethyl ester from the wax by inclusion in subsequent urea inclusion is prevented, the method is simple, rapid and effective, the content of effective components is increased, production time is shortened, and yield is improved.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a method for processing pupa oil α-ethyl linolenate bulk drug, in particular to a dewaxing method for producing pupa oil α-ethyl linolenate bulk drug and pupa oil α-ethyl linolenate The method of production of the raw material drug. Background technique [0002] α-Linolenic acid (ALA, octadeca 9,12,15-trienoic acid) is a polyunsaturated fatty acid with three double bonds (C 18 h 30 o 2 ), which is an omega-3 essential fatty acid. α-linolenic acid is the basic substance that constitutes cell membrane and biological enzymes, and plays a decisive role in human health. α-linolenic acid can be converted into DHA, DPA, EPA, etc. in the body. Since there are three conjugated double bonds in the α-linolenic acid molecule, it has very strong reducibility. It can be oxidized by high temperature, oxygen in the air, ultraviolet rays and some heavy metal ions, so it is often converted into ethyl es...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C67/03C07C67/48C07C69/587
CPCC07C67/03C07C67/48C07C69/587
Inventor 刘荣逵
Owner 北京百慧生化制药有限责任公司
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