Crylic acid polymer nano-particle and preparing method thereof
A nanoparticle and acrylic technology, which is applied in the field of acrylic polymer nanoparticle materials and its preparation, can solve the problems of difficult mass production, low yield, difficult adjustment of particle size, etc.
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[0065] A preparation method of the acrylic polymer nanoparticles, comprising the steps of:
[0066] S1, dispersing the polymer in an organic solvent;
[0067] S2, adding a protective auxiliary agent to the solution in step S1, so that the carboxyl groups in the polymer are ionized and negatively charged;
[0068] S3, adding a cross-linking agent into the solution in step S2 to cause an intramolecular cross-linking reaction of the polymer;
[0069] S4. Perform dialysis and freeze-drying on the product of step S3.
[0070] The organic solvent in step S1 is one of N,N-dimethylformamide (DMF), tetrahydrofuran (THF), dimethylsulfoxide (DMSO) and dioxane.
[0071] The polymer concentration in step S1 is 0.01-300 mg / mL, preferably 0.05-150 mg / mL.
[0072] In step S2, the protective auxiliary agent is selected from one of 1-alkylimidazoles.
[0073] In step S2, the dosage of the protective auxiliary agent is 0.1:1-0.9:1 in molar ratio of imidazole group to carboxyl group in the po...
Embodiment 1
[0081] [Example 1] Polyacrylic acid (PAA) polymer nanoparticles were prepared under the condition of 5% solid content.
[0082] (1) Take 50mg PAA 16k The solid was dissolved in 1 mL of DMF, 1-methylimidazole was added at a molar ratio of 0.4:1, and stirred rapidly at a constant temperature of 25°C for 12 hours.
[0083] (2) In the above system, the cross-linking agent 1,6-hexamethylene diisocyanate was added in batches at a molar ratio of 0.6:1 to the carboxyl group, and the intramolecular cross-linking reaction was carried out by rapid stirring at a constant temperature of 25°C for 12 hours. The obtained polymer nanoparticle is processed by dialysis and freeze-drying.
Embodiment 2
[0084] [Example 2] Polyacrylic acid (PAA) polymer nanoparticles were prepared under the condition of 15% solid content.
[0085] (1) Take 150mg PAA 16k The solid was dissolved in 1 mL of DMF, 1-methylimidazole was added at a molar ratio of 0.6:1, and stirred rapidly at a constant temperature of 25°C for 24 hours.
[0086] (2) In the above system, the crosslinking agent 1,6-hexamethylene diisocyanate was added in batches at a molar ratio of 0.4:1 to the carboxyl group, and the intramolecular crosslinking reaction was carried out by rapid stirring at a constant temperature of 25°C for 12 hours. The obtained polymer nanoparticle is processed by dialysis and freeze-drying.
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