Method for obtaining nuclear magnetic resonance two-dimensional phase-sensitive J spectrum

A technology of nuclear magnetic resonance and nuclear magnetic tubes, which is applied in the field of nuclear magnetic resonance spectroscopy detection, can solve problems such as spectral peak width broadening, and achieve the effects of improving application, improving spectral resolution, and expanding application range

Active Publication Date: 2017-06-13
XIAMEN UNIV
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Problems solved by technology

[0003] The purpose of the present invention is to provide a method for obtaining NMR two-dimensional phase-sensitive J spectrum that can effectively solve the problems of spectral peak width broadening and strong coupling false peaks in the conventional two-dimensional J spectrum absolute value display mode

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  • Method for obtaining nuclear magnetic resonance two-dimensional phase-sensitive J spectrum
  • Method for obtaining nuclear magnetic resonance two-dimensional phase-sensitive J spectrum
  • Method for obtaining nuclear magnetic resonance two-dimensional phase-sensitive J spectrum

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Embodiment Construction

[0022] Below in conjunction with accompanying drawing and embodiment, the present invention will be further described:

[0023] The instrument used in this embodiment is a Varian 500MHz nuclear magnetic resonance spectrometer, and the sample is butyl methacrylate. The pulse sequence used is as figure 1 shown. The operation steps are as follows:

[0024] 1) Sample injection: put a certain amount of butyl methacrylate sample (about 0.55mL) into the NMR spectrometer.

[0025] 2) RF pulse width measurement: use the one-dimensional proton spectrum sequence (SPULS) that comes with the spectrometer to measure the non-selective 90° frequency pulse width of the sample to be 14.35 μs, obtain the formant distribution and spectral width information, and set the The center of the spectrum is the pulse excitation center.

[0026] 4) Import the experimental pulse sequence: import the designed and compiled two-dimensional phase-sensitive J-spectrum pulse sequence (such as figure 1 shown)...

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Abstract

The invention relates to a method for obtaining a nuclear magnetic resonance two-dimensional phase-sensitive J spectrum. The method comprises the following steps: putting a to-be-tested sample into a nuclear magnetic tube and conveying the nuclear magnetic tube loaded with the to-be-tested sample into a detection chamber of a magnetic resonance spectrometer; invoking a conventional one-dimensional hydrogen spectrum pulse sequence to acquire a one-dimensional hydrogen spectrum, obtaining signal peak distribution and spectrum width information, and measuring the non-selective 90-degree radio frequency pulse width; inputting a compiled two-dimensional phase-sensitive J spectrum pulse sequence into the nuclear magnetic resonance spectrometer, opening a chiro pulse weak selection layer gradient combination module and a two-dimensional phase-sensitive J spectrum pulse sequence sampling module of the two-dimensional phase-sensitive J spectrum pulse sequence; setting two-dimensional phase-sensitive J spectrum pulse sequence experiment parameters, inspecting that the experiment parameters are set correctly, and then executing data sampling; after the completion of data sampling, performing corresponding data splicing and two-dimensional Fourier transform to obtain a two-dimensional frequency spectrum containing J coupling information and chemical displacement information; performing two-dimensional phase-sensitive treatment on the obtained two-dimensional frequency spectrum to obtain the two-dimensional phase-sensitive J spectrum.

Description

technical field [0001] The invention relates to a nuclear magnetic resonance (NMR, Nuclear Magnetic Resonance) spectroscopy detection method, in particular to a method for obtaining a two-dimensional phase-sensitive J-spectrum of nuclear magnetic resonance through simple pulse sequence design and data post-processing. Background technique [0002] NMR two-dimensional J spectroscopy (2D J spectroscopy) can realize the separation of J-coupling information and chemical shift information and display these two kinds of information in two spectral dimensions, which is helpful for the identification of peak-crowded compounds in one-dimensional spectra. Identify and assign peaks to simplify spectral analysis. The conventional two-dimensional J spectrum method is affected by the phase modulation of the indirect dimension evolution period and the direct dimension sampling period, so that the final two-dimensional J spectrum peaks are often subject to phase distortion in two dimensions...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N24/08
CPCG01N24/08
Inventor 黄玉清陈忠谭春华蔡淑惠赖伟楠詹昊霖李晨
Owner XIAMEN UNIV
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